Publications by authors named "Zonghan Jiang"
Citrinin (CTN) is a mycotoxin commonly found in contaminated foods and feed, posing health risks to both humans and animals. However, the mechanism by which CTN damages the intestine remains unclear. In this study, a model of intestinal injury was induced by administering 1.
View Article and Find Full Text PDFMulti-drug resistance of bacteria producing extended-spectrum β-lactamase (ESBL) is a public health challenge. Thus, this study aimed to investigate the antimicrobial susceptibility of ESBL-producing (ESBL-EC) in Hunan Province, China. A total of 1366 fecal samples were collected from pig, chicken, and cattle farms over a six-year period, which were assessed using strain isolation, 16S rRNA identification, polymerase chain reaction, drug sensitivity testing, whole-genome sequencing, and bioinformatics analysis.
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- - This study aims to create a fast and reliable method for detecting toxic mushroom compounds using mass spectrometry, eliminating the need for expert identification of mushroom types.
- - Toxins are extracted from mushrooms using a direct electrospray probe, and results are analyzed for sensitivity, precision, and turnaround time, achieving quick identification within just one minute.
- - The method demonstrated effective limits of detection and high accuracy, showing promise for aiding emergency healthcare providers in diagnosing and treating mushroom poisoning cases promptly.
Characteristics of (X4)-Producing in Chicken and Pig Farms in Hunan Province, China.
Antibiotics (Basel)
January 2023
Background: The plasmid-mediated tigecycline resistance gene (X4) confers a high level of resistance to tigecycline. The experiment aims to investigate the prevalence and characterization of (X4) in isolates from chicken and pig farms in Hunan province, China.
Methods: A total of six (X4) positive strains were identified in 257 derived from chicken samples in Xiangtan city ( = 2), pig samples in Xiangxiang city ( = 1), Chenzhou city ( = 2), and Zhuzhou city ( = 1).
Despite the fact that carbamates and organophosphates cause acute poisoning via different mechanisms and require disparate management, they are indistinguishable by current clinical assays. Herein, direct immersion solid-phase microextraction (DI-SPME) plus thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was developed to discern them. Both pesticides spiked in human serum were extracted by SPME and analyzed by TD-ESI/MS/MS.
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- Ambient ionization mass spectrometry (AIMS) allows for quick identification of trace organic and biological compounds with little to no sample preparation, making the process efficient.
- A new analytical platform using thermal desorption-electrospray ionization/mass spectrometry (TD-ESI/MS) successfully differentiates bacterial species based on lipid profiles, achieving fast results—often within 1 minute.
- The study confirmed the effectiveness of this method through statistical analysis (PCA and HCA) and compared it to protein profiling using MALDI-TOF, showcasing its potential as a diagnostic tool in clinical settings.
Thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was used to rapidly characterize the residual pesticides collected on the surface of a strawberry with a metallic probe. Twelve pesticides, including nine fungicides and three miticides, were detected; the results were validated by comparison with results that used solvent extraction followed by gas chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry analyses. The distribution of pesticide residues on a strawberry's surface was explored by collecting multiple samples using probes from 40 positions on the strawberry, with the collected samples being analyzed with TD-ESI/MS/MS.
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- Dermal exposure to pesticides can lead to serious health issues or death, emphasizing the need for quick identification and decontamination methods in emergency situations.
- A rapid analytical technique using thermal desorption electrospray ionization mass spectrometry was developed to detect pesticide presence on the skin and confirm successful decontamination, taking less than 30 seconds.
- The method showed high repeatability and sensitivity, with PVC fabric providing the best skin protection and detergent being the most effective at removing pesticide fenthion.