Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression.

Introduction: Chronic spinal compression is a common complication of spinal cord injury (SCI), which can lead to spinal stenosis or herniated discs. The ensuing neuropathic pain is often associated with the activation of microglia. In this investigation, our objective was to explore whether modifying the levels of chemokine (C-C motif) ligand 2 (Ccl2) in microglia could alleviate neuropathic pain resulting from chronic spinal compression.

The uncoupled anterior and posterior spinal ligament tension (UAPLT) - An improvement to three-dimensional spring model of adolescent idiopathic scoliosis (AIS) pathogenesis.

The pathogenesis of Adolescent Idiopathic Scoliosis (AIS) remains unclear. Previous research proposed that ligament laxity is a clinical feature that can be easily overlooked in patients with AIS. We speculated a new hypothesis which is an improvement of our three-dimensional spring model hypothesis of AIS pathogenesis.

Upregulation of cGMP-dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis.

Objective: To explore the molecular regulatory mechanisms underlying fibroblast differentiation and dysfunction in the development of adolescent idiopathic scoliosis (AIS) in an effort to identify candidate therapeutic targets for AIS.

Methods: The GSE110359 dataset, obtained from the bone marrow stromal cells of 12 AIS patients and five healthy controls, was retrieved from the GEO database. The data were preprocessed and differentially expressed genes (DEGs) were identified.

Postoperative neck tilt in Lenke 1 and 2 AIS patients after correction surgery: a novel predictive index.

Background: Postoperative neck tilt (PNT) is a phenomenon in adolescent idiopathic scoliosis (AIS) patients which is distinct form shoulder imbalance. There were scarce studies performed to explore the risk factors for PNT in Lenke 1 and 2 AIS patients, and whether it can be predicted after surgery remains unknown. The objective of this study is to explore the prevalence and risk factors for PNT, and introduce an index for prediction of PNT in Lenke 1 and 2 AIS patients after correction surgery.

Dysregulated COL3A1 and RPL8, RPS16, and RPS23 in Disc Degeneration Revealed by Bioinformatics Methods.

Study Design: Bioinformatics analysis of published microarray data.

Objective: This study aimed to reveal the possible genes and pathways related to the pathogenesis of disc degeneration (DD) by analyzing the microarray data.

Summary Of Background Data: DD is one of the main causes of low back pain, which has become an enormous economic burden for society.

Gene sequence analysis and screening of feature genes in spinal cord injury.

The aim of the present study was to screen for feature genes associated with spinal cord injury (SCI), in order to identify the underlying pathogenic mechanisms. Differentially expressed genes were screened for using pre‑processing data. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was performed to analyze and identify the genes involved in pathways associated with SCI.

Identification of the relationships between sagittal plane and coronal plane curvature in guppy models.

Objective: To explore the relationship between sagittal plane and coronal plane curvatures in guppies by investigating the curvature angles of sagittal and sagittal-coronal guppies.

Methods: After mating between 1000 spinal curvature guppies, 124 guppies (3-month old) were screened from progenies for the present study. Photos of all fishes were taken and the sagittal and coronal angles were calculated via angle measure tool of Photoshop 12.

A valid cross-culturally adapted simplified Chinese version of the Quebec Back Pain Disability Scale.

Objective: To evaluate the reliability and validity of the simplified Chinese version of the Quebec Back Pain Disability Scale (SC-QDS).

Study Design And Setting: The QDS was translated and cross-culturally adapted into SC following international guidelines. The SC-QDS was completed by 114 patients with low back pain (LBP) and 65 healthy controls, along with the SC Oswestry Disability Index (SC-ODI) and visual analogue scale (VAS).

There may be a same mechanism of the left-right handedness and left-right convex curve pattern of adolescent idiopathic scoliosis.

The mechanism of the left-right handedness and pathogenesis of adolescent idiopathic scoliosis (AIS) is still unclear. We speculated that the pathogenesis of AIS may different from the mechanism of the laterality of convex curve pattern in AIS patients. This laterality may have correlation with the right dominance of handedness.

High selenium may be a risk factor of adolescent idiopathic scoliosis.

The pathogenesis of adolescent idiopathic scoliosis (AIS) remains little understood. Previous work has shown that guppy fish is an ideal animal model of idiopathic scoliosis which has similar epidemiological and morphological characteristic with AIS. However, some research speculated that the high-selenium environment could also induce idiopathic-type scoliosis of fish.

Three-dimensional spring model: a new hypothesis of pathogenesis of adolescent idiopathic scoliosis.

The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to formation of normal curvature of the spine in the sagittal plane during the childhood.