Publications by authors named "Zongbo Dai"
Article Synopsis
- The study investigates preoperative biliary drainage (PBD) and optimal bilirubin levels for patients with hilar cholangiocarcinoma (HC) who are undergoing hemi-hepatectomy to improve surgical outcomes.
- It analyzes data from 83 HC patients over 11 years, finding that preoperative bilirubin levels significantly impact liver regeneration and postoperative liver health.
- Results indicate a bilirubin cut-off of 103.15 μmol/L, under which patients experience better liver recovery and fewer complications post-surgery, highlighting the potential benefits of PBD in certain cases.
Background: The heterogeneity of the tumor microenvironment significantly influences the prognosis of hepatocellular carcinoma (HCC) patients, with cell communication through ligand-receptor complexes playing a central role.
Methods: We conducted single-cell transcriptomic analysis on ten HCC tissues to identify ligand-receptor genes involved in malignant HCC cell communication using CellChat. Leveraging RNA-Seq data from the TCGA Liver Cancer (TCGA-LIHC) and Liver Cancer - RIKEN, JP (LIRI-JP) cohorts, we employed Cox regression analysis to screen for prognosis-related genes.