Publications by authors named "Zong-xin Ling"
Multiple sclerosis (MS) is an autoimmune disorder caused by chronic inflammatory reactions in the central nervous system. Currently, little is known about the changes of plasma proteomic profiles in Chinese patients with MS (CpwMS) and its relationship with the altered profiles of multi-omics such as metabolomics and gut microbiome, as well as potential molecular networks that underlie the etiology of MS. To uncover the characteristics of proteomics landscape and potential multi-omics interaction networks in CpwMS, Plasma samples were collected from 22 CpwMS and 22 healthy controls (HCs) and analyzed using a Tandem Mass Tag (TMT)-based quantitative proteomics approach.
View Article and Find Full Text PDF[This corrects the article on p. 2394 in vol. 27, PMID: 34040330.
View Article and Find Full Text PDF[Dynamic Microbial Shifts and Functional Analysis of Saliva Microbial Communities with Caries Children].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2022
Objective: To observe the dynamic changes in the salivary microbiota of children with dental caries and those who were caries-free and to analyze the functional differences in the oral microecology of the two groups during the course of sugar metabolism and the synthesis and transport of multiple amino acids.
Methods: Ten children with dental caries and 10 caries-free children were enrolled. We employed Illumina metagenomics technology to analyze the composition and function of salivary microbiome in children with and without caries.
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disorder characterized by damage to nerve axons due to demyelination, and recent studies indicate altered metabolic profiles in MS patients, potentially impacting disease progression.
- In a study of Chinese patients with MS, researchers identified 42 different metabolites in blood samples, noting significant reductions in certain amino acids and lipids, along with heightened levels of pro-inflammatory cytokines like IL-17 and TNF-α.
- Findings suggest that these metabolomic changes could influence immune responses, contributing to the pathogenesis of MS by affecting inflammatory processes in the body.
Background: Gut microbiota dysbiosis is reportedly actively involved in autoimmune diseases such as type 1 diabetes mellitus (T1DM). However, the alterations in the gut microbiota and their correlation with fasting blood glucose (FBG) in Chinese children with T1DM remain unclear.
Aim: To investigate alterations in the gut microbiota in Chinese children with T1DM and their associations with clinical indicators.
Resibufogenin (RB) has been used for cancer treatment, but the underlying mechanisms are still unclear. This study aimed to investigate the effects of RB treatment on colorectal cancer (CRC) cells, and to determine the underlying mechanisms. The cell counting kit-8 assay was used to determine cell viability.
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- Gastric microbiota serves as a crucial barrier against pathogens from the mouth, helping to maintain gut health, while certain bacteria (specifically serotype K1) can lead to infections, including liver abscesses in mice.
- A study utilized pyrosequencing to analyze how gastric microbiota changes in response to KLA infection, revealing significant differences before and after oral inoculation, particularly in the abundance of certain bacterial taxa.
- The increase in specific bacteria and endogenous antibiotics in the stomach and intestines suggests a strong connection between gastric microbiota and KLA infection, offering insights for potential clinical treatments.
Intestinal microbiota plays a crucial role in preventing the colonization and invasion by pathogens, and disruption of microbiota may cause opportunistic infections and diseases. Pathogens often have strategies to escape from the colonization resistance mediated by microbiota, but whether they also modulate the microbiota composition is still a topic of investigation. In the present study, we addressed this question using an opportunistic pathogen, Klebsiella pneumoniae serotype K1, which is known to cause pyogenic liver abscess (KLA) in about 30% of mice.
View Article and Find Full Text PDFIntroduction: The response rate to hepatitis B virus (HBV) vaccination in patients with inflammatory bowel disease (IBD) is low and varies markedly. We performed a systematic review and meta-analysis to determine the response rate to HBV vaccination and identified the factors predictive of an immune response.
Methods: We searched PubMed, Cochrane Library, and Embase databases, and reviewed the titles and abstracts of studies on the efficacy of HBV vaccination in IBD patients performed through July 2016.
Article Synopsis
- * The analysis included 15 studies with over 40,000 ASD cases, finding a significant overall increased risk (OR=1.13) and an even higher risk (OR=1.30) among hospitalized cases.
- * Factors such as the type of infection, timing, and location of infection can influence the level of risk, with potential mechanisms involving both direct pathogen effects and inflammatory responses impacting brain development.
In the present study, we report the whole genome sequences of two species, Ornithinibacillus contaminans DSM22953(T) isolated from human blood and Ornithinibacillus californiensis DSM 16628(T) isolated from marine sediment, in genus Ornithinibacillus. Comparative genomic study of the two species was conducted together with their close relative Ornithinibacillus scapharcae TW25(T), a putative pathogenic bacteria isolated from dead ark clam. The comparisons showed O.
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- This systematic review and meta-analysis examined the link between serum vitamin D levels and the severity of liver fibrosis in patients with chronic hepatitis C, analyzing data from approximately 8,321 participants across six studies.
- It found that lower serum vitamin D levels may be associated with increased severity of liver fibrosis, based on mean data from three studies, but not a consistent conclusion could be drawn from the odds ratio data from four other studies.
- Significant variability was noted among the studies, indicating that while there is a potential risk factor relationship between low vitamin D and liver fibrosis severity, the evidence is not definitive due to inconsistencies in the data.
Changes of gut bacteria and immune parameters in liver transplant recipients.
Hepatobiliary Pancreat Dis Int
February 2012
Article Synopsis
- Liver transplantation is effective for end-stage liver disease, but the role of gut microbiota in infections during and after the process remains unclear.
- A study from China analyzed fecal and blood samples from 190 participants to assess the relationship between gut bacteria diversity and immune responses in liver transplant recipients.
- Results indicated that specific beneficial bacteria were lower and harmful bacteria were higher in liver transplant patients, with some microbiota changes returning to normal over time post-transplant, while certain immune markers increased in cirrhotic patients but not in transplant recipients.