Publications by authors named "Zong-Yuan Yang"
Article Synopsis
- Therapy-induced senescence (TIS) in tumor cells treated with PARP inhibitors (PARPis) can negatively impact treatment effectiveness, and this study investigates whether the surrounding stromal components also experience TIS, contributing to resistance.
- The research found that stromal fibroblasts in tumor tissues from patients treated with neoadjuvant PARPis displayed a senescence-like phenotype and created a secretory environment (SASP) that led to tumor resistance against these therapies.
- Bepotastine, an H1-antihistamine, was shown to inhibit the SASP from PARPi-primed cancer-associated fibroblasts, suggesting that targeting this mechanism could enhance PARPi sensitivity in ovarian cancer.
Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays a pivotal role in regulating the malignant phenotype, and has the potential in developing therapeutically valuable targets that improve the dismal outcome of this disease. Here we show that a series of transcription factors, including C/EBPβ, GCM1, and GATA1, could act as potential modulators of histone methylation in tumor cells.
View Article and Find Full Text PDFLong-term outcome of high-grade serous epithelial ovarian carcinoma (HGSOC) remains poor as a result of recurrence and the emergence of drug resistance. Almost all the patients were given the same platinum-based chemotherapy after debulking surgery even though some of them are naturally resistant to the first-line chemotherapy. No method could verify this part of patients right after the surgery currently.
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