Six-year analysis of key monitoring for bacterial strain distribution and antibiotic sensitivity in a hospital.

Background: With the widespread use of antimicrobial drugs, bacterial resistance has become a significant problem, posing a serious threat to public health. The prevalence of clinical infection strains in hospitals and their drug sensitivities are key to the appropriate use of antibiotics in clinical practice.

Aim: To identify prevalent bacteria and their antibiotic resistance profiles in a hospital setting, thereby guiding effective antibiotic usage by clinicians.

Astragaloside IV improves renal function and alleviates renal damage and inflammation in rats with chronic glomerulonephritis.

From (Fisch.) Bge.var.

Chiral Assembly and Recognition of Seven Copper (II) Coordination Polymers from Tartaric Acid Derivative Ligands.

A pair of enantiomeric ligands, (2R,3R)-dibenzyl-2,3-bis(isonicotinoyloxy)succinate ((R,R)-L) and (2S,3S)-dibenzyl-2,3-bis(isonicotinoyloxy)succinate ((S,S)-L), are designed and synthesized. Seven copper (II) coordination polymers {[Cu((R,R)-L)Br (THF)] ⋅ CH CN} (1 a) and {[Cu((S,S)-L)Br (THF)] ⋅ CH CN} (1 b), {[Cu((R,R)-L)Cl (THF)] ⋅ CH CN} (2 a) and {[Cu((S,S)-L)Cl (THF)] ⋅ CH CN} (2 b), {[Cu((R,R)-L)(NO ) (CH CN)]} (3 a) and {[Cu((S,S)-L)(NO ) (CH CN)]} (3 b), {[Cu((R,R)-L) (CH CN) ](ClO )  ⋅ 3CH CN} (4) were obtained through the assemblies with CuBr , CuCl  ⋅ 2H O, Cu(NO )  ⋅ 3H O, Cu(ClO )  ⋅ 6H O, respectively. Single-crystal X-ray diffraction and circular dichroism analysis demonstrate that 1 a-3 a, 1 b-3 b have a mono chiral one-dimensional (1D) chain-like spiral structure, while 4 have 1D chain-like structure whose metal centers have chiral propeller coordination environment.

Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve.

Background: The underlying mechanism of exercise on neuropathic pain is not well understood. We investigated whether physical exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-α (TNF-α), and interlukin-1β (IL-1β) expression after chronic constriction injury (CCI) of the sciatic nerve.

Methods: Male Sprague-Dawley rats were divided into 7 groups: control, sham operated (SO), SO with swimming or treadmill exercise (SOSE or SOTE), CCI, CCI with swimming or treadmill exercise (CCISE or CCITE).

Spinal anesthesia with diphenhydramine and pheniramine in rats.

The aim of this study was to evaluate the local anesthetic effects of pheniramine and diphenhydramine, two histamine H₁ receptor antagonists, on spinal anesthesia and their comparison with lidocaine, a commonly used local anesthetic. After rats were injected intrathecally with diphenhydramine and pheniramine, the dose-response curves were obtained. The potency and duration of diphenhydramine and pheniramine on spinal anesthesia were compared with lidocaine.