Aminated β-cyclodextrin-grafted FeO-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation.

Based on aminated β-cyclodextrin (6-NH-β-CD)-grafted FeO and gambogic acid (GA) clathrate complexes, a nanoparticle delivery system was developed with the aim to achieve low irritation, strong targeting, and high bioavailability of a gambogic acid magnetic nanopreparation. 6-NH-β-CD grafted onto FeO MNPs was demonstrated by high-resolution transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, zeta potential, and magnetic measurements. The average particle size of the FeO@NH-β-CD MNPs was 147.