Publications by authors named "Zong-Wei Lin"
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, has known as one of the most significant pathological processes involved in diabetic kidney disease (DKD). Stimulator of interferon genes (STING) has been demonstrated its potential in regulating ferroptosis, but the regulatory role in DKD mice and underlying mechanisms haven't been illustrated. To elucidate whether and how STING regulates ferroptosis in DKD, we detected the influence of STING on diabetic-related ferroptosis in a diabetic model and in erastin-induced renal tubular epithelial cells (RTECs).
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- The study investigated the effects of sacubitril/valsartan on heart failure patients with reduced ejection fraction and low systolic blood pressure, focusing on those with SBP < 100 mmHg.
- Results showed that 52.4% of patients with low SBP and 70.0% with normal SBP reached target dosages after 6 months, with similar reductions in a heart failure biomarker across both groups.
- Sacubitril/valsartan improved left ventricular ejection fraction in both SBP categories and was well tolerated, indicating its potential benefit even for patients with asymptomatic hypotension.