Publications by authors named "Zong-Wei Fan"
Article Synopsis
- The intermitochondrial cement (IMC) and chromatoid body (CB) in mice are crucial for the activity of piRNA, with the protein MIWI initially assembling in the IMC for piRNA processing before moving to the CB for its functions.
- The loading of piRNA is identified as the key factor triggering MIWI's movement from the IMC to the CB by weakening its connection with TDRKH, which is anchored to mitochondria.
- Without the ability to load piRNAs, MIWI gets stuck in the IMC, leading to instability in male germ cells and resulting in issues like defective sperm production and infertility.
