Publications by authors named "Zong-Shu Xian"
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). We induced experimental MI in mice by ligation of the left ascending artery and evaluated the effect of IL-22 on post-MI cardiac function and ventricular remodeling.
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- F-652 is a recombinant fusion protein made from two IL-22 molecules linked to an IgG-Fc region, important for tissue repair and fighting bacterial infections.
- A study with healthy male volunteers showed that while there were mild injection site reactions after subcutaneous administration, no severe adverse events occurred following intravenous doses.
- The intravenous administration of F-652 demonstrated safe and favorable pharmacokinetics, indicating potential for further clinical development in treating inflammatory diseases.