Publications by authors named "Zong-Shin Lin"
Article Synopsis
- Chondrosarcomas are aggressive cancers originating from cartilage, with a poor prognosis and a five-year survival rate of only 11 months for the dedifferentiated subtype.
- Surgical removal is currently the only effective treatment, as other therapies like targeted treatments and chemotherapy are not viable options.
- Research identified the EZH2/SULF1/cMET signaling pathway as a key factor in chondrosarcoma progression, suggesting that targeting this pathway could lead to new treatment strategies.
Article Synopsis
- - Chondrosarcoma is a common and malignant bone tumor that's resistant to chemo and radiation, leaving amputation as the primary treatment, which greatly affects patients' lives.
- - Research is needed to better understand the disease at a molecular level for improved prognosis and targeted therapies.
- - The study identifies the transcription factor FOXA1, which boosts the expression of the cyclin B1 gene, promoting cell cycle progression in chondrosarcoma cells.
Mesenchymal stem cells (MSCs) have a high self-renewal potential and can differentiate into various types of cells, including adipocytes, osteoblasts, and chondrocytes. Previously, we reported that the enhancer of zeste homolog 2 (EZH2), the catalytic component of the Polycomb-repressive complex 2, and HDAC9c mediate the osteogenesis and adipogenesis of MSCs. In the current study, we identify the role of p38 in osteogenic differentiation from a MAPK antibody array screen and investigate the mechanisms underlying its transcriptional regulation.
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