Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer.

Growing evidence suggests that microRNA plays an essential role in the development and metastasis of many tumors, including gastric cancer. Aberrant miR‑370 expression has been indicated in tumor growth, but the mechanism of miR‑370 inhibits both the proliferation and metastatic ability for gastric cancer remains unclear. Accumulating evidence reported that PTEN signaling pathway plays an important role in the cellular processes, such as apoptosis, cell growth and proliferation.

[Evaluation on schistosomiasis control effect of the intervention measures adapted to the ecological environment changes in Jiang Han Plain due to establishment of the Three Gorges dam].

Objective: To evaluate the effect of the intervention measures for schistosomiasis control adapted to the ecological environment changes in Jiang Han plain caused by the establishment of the Three Gorges Dam.

Methods: Four villages in Qianjiang City were selected to implement paddy-upland rotation, crawfish-paddy alternation, water control and soil improvement, and adjusting agricultural structure to rebuild the waterlogging low yielding land and to change the snail habitat environment respectively. The snail habitat area, mean density of living snails and prevalence of schistosomiasis in human and cattle were compared with those of the control villages.