Preparation and characterization of glucoamylase microcapsules prepared by W/O/W type complex coacervation freeze drying.

Glucoamylase was often used in the brewing industry but was unstable to several environmental factors and reacted quickly to produce fermentable sugar, which limited its applications. Microencapsulation could effectively overcome the drawbacks. This study evaluated the feasibility of the preparation of glucoamylase microcapsules (GM) using W/O/W complex coacervation-freeze-drying method.

Prostate cancer malignancy detection and localization from mpMRI using auto-deep learning as one step closer to clinical utilization.

Automatic diagnosis of malignant prostate cancer patients from mpMRI has been studied heavily in the past years. Model interpretation and domain drift have been the main road blocks for clinical utilization. As an extension from our previous work we trained on a public cohort with 201 patients and the cropped 2.

Crystal Structure and Bond-Valence Investigation of Nitrogen-Stabilized LiAlO Spinels.

An in-depth insight into the effect of nitrogen substitution on structural stabilization is important for the design of new spinel-type oxynitride materials with tailored properties. In this work, the crystal structures of ordered and disordered LiAlO obtained by slow cooling and rapid quenching, respectively, were analyzed by a X-ray diffraction (XRD) Rietveld refinement and OccQP program. The variation in the bonding state of atoms in the two compounds was explored by the bond valence model, which revealed that the instability of spinel-type LiAlO crystal structure at room temperature is mainly due to the severe under-bonding of the tetrahedrally coordinated Al cations.

Resveratrol regulates -mediated mitophagy via the lncRNA axis, and enhances the antitumor activity of paclitaxel against non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is a common malignant subtype of lung cancer with high mortality. Resveratrol (RSV) is a natural molecule that regulates mitochondrial metabolism. Here, we explored the effect of RSV on NSCLC cell mitophagy and paclitaxel (PTX) resistance.

Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.

The beneficial effects of photobiomodulation (PBM) on function recovery after stroke have been well-established, while its molecular and cellular mechanisms remain to be elucidated. The current study was designed to investigate the effect of PBM on synaptic proteins and astrocyte polarization of photothrombotic (PT)-stroke induced rats in vivo, and explore the possible effect of PBM treatment on oxygen-glucose deprivation (OGD)-induced neurotoxic astrocytic polarization in vitro. We reported that 2-min PBM treatment (808 nm) for 7 days significantly increased synaptic proteins and neuroprotective astrocytic marker S100 Calcium Binding Protein A10 (S100A10) and inhibited neurotoxic astrocytic marker C3d in the peri-infarct region after ischemic stroke.

Enhanced light-matter interactions in ultrathin transition-metal-dichalcogenide metasurfaces by magnetic and toroidal dipole bound states in the continuum.

Nonradiating states of light have recently received a lot of attention in nanophotonics owing to their ability to confine and enhance the electromagnetic fields at the nanoscale. Such optical states not only offer a promising way to overcome the problem of losses associated with plasmonic materials, but also constitute an efficient platform for interaction of light and matter. Here, we report the radiationless states in compact, ultrathin transition-metal-dichalcogenide metasurfaces, namely bound states in the continuum (BICs).

Chromosome-length genome assemblies of six legume species provide insights into genome organization, evolution, and agronomic traits for crop improvement.

Introduction: Legume crops are an important source of protein and oil for human health and in fixing atmospheric N for soil enrichment. With an objective to accelerate much-needed genetic analyses and breeding applications, draft genome assemblies were generated in several legume crops; many of them are not high quality because they are mainly based on short reads. However, the superior quality of genome assembly is crucial for a detailed understanding of genomic architecture, genome evolution, and crop improvement.

Functional physiological phenotyping and transcriptome analysis provide new insight into strawberry growth and water consumption.

Global warming is expected to increase agricultural water scarcity; thus, optimized irrigation schedules are important and timely for sustainable crop production. Deficit irrigation, which balances crop growth and water consumption, has been proposed, but the critical threshold is not easily quantified. Here, we conducted experiments on strawberry plants subjecting progressive drought following various water recovery treatments on the high-throughput physiological phenotyping system "Plantarray".

Secular trends in age at pubertal onset assessed by breast development among Chinese girls: A systematic review.

Background: The average age at thelarche has trended downwards worldwide since 1970s; however, the onset age of "precocious puberty", defined as the lower percentiles of thelarche age, has been rarely reported. This systematic review aims to evaluate secular trends in age at thelarche among Chinese girls.

Methods: This systematic review on the age at thelarche during puberty among Chinese girls was conducted systematic search of both Chinese (Chinese National Knowledge Infrastructure, WanFang Database, and the Chinese Scientific Journals Database) and English (PubMed, Cochrane Library, and Embase) databases.

Wedged Fiber Optic Surface Plasmon Resonance Sensor for High-Sensitivity Refractive Index and Temperature Measurements.

Here, we experimentally demonstrate a wedged fiber optic surface plasmon resonance (SPR) sensor enabling high-sensitivity temperature detection. The sensing probe has a geometry with two asymmetrical bevels, with one inclined surface coated with an optically thin film supporting propagating plasmons and the other coated with a reflecting metal film. The angle of incident light can be readily tuned through modifying the beveled angles of the fiber tip, which has a remarkable impact on the refractive index sensitivity of SPR sensors.

Protective Effect and Mechanism of Placenta Extract on Liver.

The placenta contains multiple biologically active substances, which exert antioxidation, anti-inflammatory, immunomodulatory, and delayed aging effects. Its extract can improve hepatic morphology and function: on the one hand, it can reduce liver interstitial collagen deposition, lipogenesis, and inflammatory cell infiltration and improve fibrosis; on the other hand, it can prevent hepatocellular degeneration by scavenging reactive oxygen species (ROS) and inhibiting inflammatory cytokine production, further improve hepatocyte apoptosis and necrosis, and promote hepatocyte regeneration, making it a promising liver-protective agent. Current research on placenta extract (PE) mainly focuses on treating a specific type of liver injury, and there are no systematic reports.

Response of sediment microbial communities to different levels of PAC contamination and exposure time.

Coagulants such as polyaluminium chloride (PAC) are widely used for removing phosphorus from eutrophic water, but its application for water treatment can potentially harm the environment. In this study, a four-timepoint exposure experiment was performed at week 1, 3, 7 and 10 to investigate how microbial communities in lake sediments respond to different concentrations of PAC (RS (raw lake water with nothing added), Low, Medium and High). The results showed that, while PAC can efficiently decrease the amount of C, N and P in lake water, the presence of residual aluminum and aluminum precipitates can greatly affect the microbial communities in lake sediments.

Clonal Hematopoiesis and Risk of Incident Lung Cancer.

Purpose: To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer.

Methods: Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021).

Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke.

Although bone marrow mesenchymal stem cells (BMSCs) might have therapeutic potency in ischemic stroke, the benefits are limited. The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor (VEGF) on behavioral defects in a rat model of transient cerebral ischemia, which was induced by middle cerebral artery occlusion. VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke.

IG1, a Mansonone F Analog, Exhibits Antibacterial Activity against by Potentially Impairing Cell Wall Synthesis and DNA Replication.

Infection caused by , especially methicillin-resistant (MRSA), is very common in communities and hospitals, which poses a great challenge to human health. Therefore, increasing attention has been paid to finding effective antimicrobial agents. Mansonone F is a natural compound which has an oxaphenalene skeleton and anti- activity, but its sources are limited and its synthesis is difficult.

The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases.

Background: Immune-related cutaneous diseases are a series of disorders, such as alopecia areata, psoriasis, atopic dermatitis, systemic lupus erythematosus and autoimmune bullous dermatoses. Vitamin D is a fat-soluble vitamin, which is known for its classical pleiotropic effect. Recent studies have found that vitamin D, after catalyzed into its biologically active form [1,25(OH) 2D], correlated with its receptor, vitamin D receptor, plays a vital role in multiple pathophysiological processes, including immune-related dermatoses.

LiDAR reveals a preference for intermediate visibility by a forest-dwelling ungulate species.

Visibility (viewshed) plays a significant and diverse role in animals' behaviour and fitness. Understanding how visibility influences animal behaviour requires the measurement of habitat visibility at spatial scales commensurate to individual animal choices. However, measuring habitat visibility at a fine spatial scale over a landscape is a challenge, particularly in highly heterogeneous landscapes (e.

Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice.

Placental extract has been used for skin care and delaying skin aging. Cow placenta is an abundant resource with a large mass, which has not been harnessed effectively. Cow placenta extract (CPE) has the functions of antioxidation, anti-inflammatory, promoting growth and development, and promoting hair growth.

Effect of anemoside B4 on milk whey in clinical mastitis-affected cows elucidated using tandem mass tag (TMT)-based quantitative proteomics.

Intramuscular injection of anemoside B4 (AB4) has a superior therapeutic effect on clinical mastitis in lactating cows. Here, we explored AB4's effect on milk whey in clinical mastitis-affected cows using proteomics. Among fifty clinical mastitis cows received AB4 administration (0.

One novel ACOT7-NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report.

Background: Acute lymphoblastic leukemia (ALL) is a type of heterogeneous hematopoietic malignancy that accounts for approximately 20% of adult ALL. Although ALL complete remission (CR) rate has increased to 85-90% after induction chemotherapy, 40-50% of patients eventually relapsed. Therefore, it is necessary to improve the outcomes of ALL via accurate diagnosis and individualized treatments, which benefits in part from molecular biomarkers.

Ectopic expression of NAC transcription factor HaNAC3 from Haloxylon ammodendron increased abiotic stress resistance in tobacco.

HaNAC3 is a transcriptional activator located in the nucleus that may be involved in the response to high temperature, high salt and drought stresses as well as phytohormone IAA and ABA treatments. Our study demonstrated that HaNAC3 increased the tolerance of transgenic tobacco to abiotic stress and was involved in the regulation of a range of downstream genes and metabolic pathways. This also indicates the potential application of HaNAC3 as a plant tolerance gene.

Performance evaluation of Hipee S2 point-of-care testing urine dipstick analyser: a cross-sectional study.

Objective: With advances in mobile technology, smartphone-based point-of-care testing (POCT) urinalysis hold great potential for disease screening and health management for clinicians and individual users. The purpose of this study is to evaluate the analytical performance of Hipee S2 POCT urine dipstick analyser.

Design: A multicentre, hospital-based, cross-sectional study.