[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].

Objective: To explore the potential mechanism of resistance to axitinib in clear cell renal cell carcinoma (ccRCC), with a view to expanding the understanding of axitinib resistance, facilitating the design of more specific treatment options, and improving the treatment effectiveness and survival prognosis of patients.

Methods: By exploring the half maximum inhibitory concentration (IC) of axitinib on ccRCC cell lines 786-O and Caki-1, cell lines resistant to axitinib were constructed by repeatedly stimulated with axitinib at this concentration for 30 cycles . Cell lines that were not treated by axitinib were sensitive cell lines.