Publications by authors named "Zoltan Z Nagy"

Phacoemulsification and intraocular lens (IOL) implantation comprise a standard procedure for cataract treatment. However, minimal refractive error remains a determinant of postoperative results. Our study aimed to evaluate the refractive outcomes and the impact of the surgeon's experience and the IOL model on Kosovan and Hungarian patients after cataract surgery.

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Purpose: In PAX6 syndrome, it is still not clear, whether prenatally, parallel to the iris tissue developmental anomaly, there is neural ectodermal, neural crest, or mesodermal cell deposition at the corneal endothelium, affecting endothelial structure and function. In addition, because of the postnatal corneal inflammation and commonly appearing secondary glaucoma, progressive endothelial changes are expected. Our purpose was to study the corneal endothelium in subjects with PAX6 aniridia, using in vivo confocal laser scanning microscopy.

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To evaluate prognostic factors for visual outcome in patients with diabetes who have undergone vitrectomy (PPV) for severe proliferative diabetic vitreoretinopathy (PDVR) in at least one eye in the past 15 years. Medical records of 132 eyes of 66 patients were analyzed (median age 52 years 21-80; patients with type 1/2 diabetes 40/26; median follow-up 38 months 9-125). Correlations between final favorable visual outcome defined as 0.

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We investigated the association between the SDF-1-3' (c801G > A) variant and the development of diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR) in a Hungarian cohort. SDF-1-3' (c801G > A) was genotyped in 103 patients with diabetic retinopathy and 31 age- and sex-matched non-diabetic controls. Central retinal and choroidal thickness was measured by swept-source optical coherence tomography.

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Purpose: Our study aimed to evaluate the indications and outcomes of intraocular lens (IOL) explantation surgeries in a tertiary eyecare center in Hungary.

Materials And Methods: This retrospective study included all IOL explantation surgeries performed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary. There were no exclusion criteria for this study.

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Article Synopsis
  • * A majority of cases were linked to medications, with nonsteroidal anti-inflammatory drugs (NSAIDs) being the most common culprit, and many patients experienced chronic eye issues such as conjunctival hyperemia and corneal scarring.
  • * Treatment included topical antibiotics, artificial tears, and various surgeries, with procedures like epilation for trichiasis and cataract surgery being common for managing long-term ocular complications.
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Uveal melanoma (UM) is the most common primary malignant ocular tumour in adults, although its epidemiology in Central and Eastern Europe is unclear. This study aimed to analyse the incidence and all-cause mortality of UM in Hungary. This nationwide, retrospective, longitudinal study used data from the National Health Insurance Fund and included patients aged ≥18 years who were newly diagnosed with UM (ICD-10 C69.

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Article Synopsis
  • The study evaluates the effectiveness of defocus incorporated multiple segments (DIMS) spectacle lenses in reducing myopia progression in a Central European pediatric population aged 4-17 years, with myopia levels ranging from -0.88 to -8.25 D.
  • Over a 12-month period, results showed that while myopia progression was similar to previous studies, 50% of participants exhibited no progression, with factors like younger age, baseline astigmatism, and maternal myopia influencing treatment outcomes.
  • Participants reported high satisfaction with the DIMS treatment, experiencing few side effects that diminished over time, indicating the need for more research on the role of astigmatism in myopia management.
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Purpose: During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial cell differentiation and abnormal cell adhesion, which leads to centripetal spreading vascularization, conjunctivalization, and thickening of the cornea. Our aim was to examine the subbasal nerve plexus and central corneal stromal microstructure in subjects with congenital aniridia, using confocal laser scanning microscopy CLSM.

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Cystinosis is a low-prevalence lysosomal storage disease. The pathomechanism involves abnormal functioning of the cystinosine lysosomal cystine transporter (CTNS), causing intraliposomal accumulation of the amino acid cysteine disulfide, which crystallizes and deposits in several parts of the body. The most common ophthalmic complication of cystinosis is the deposition of "gold dust" cystine crystals on the cornea, which already occurs in infancy and leads to severe photosensitivity and dry eyes as it gradually progresses with age.

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Article Synopsis
  • - Myopia is becoming more prevalent among young people globally, posing a risk of serious vision impairment in the future, which makes effective treatment options essential
  • - Advances in understanding myopia's causes and management techniques are rapid, yet significant information gaps hinder the development of comprehensive intervention plans
  • - An algorithm has been proposed to guide eye care providers in creating individualized myopia management strategies, integrating the latest research and various preventive and intervention methods
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This study aimed at analyzing the corneal neural regeneration in ankylosing spondylitis patients using in vivo corneal confocal microscopy in correlation with Langerhans cell density, morphology, and dry eye parameters. Approximately 24 ankylosing spondylitis subjects and 35 age- and gender-matched control subjects were enrolled. Data analysis showed that all corneal nerve-fiber descriptives were lower in the ankylosing spondylitis group, implicating disrupted neural regeneration.

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Article Synopsis
  • The study evaluated two methods for analyzing vascular density in OCTA images: the established Mexican hat filtering (MHF) and the novel Shanbhag thresholding (ST), using images from 38 healthy subjects.
  • MHF generally produced higher values for Skeleton Density (SkD) and Vessel Density (VD), while ST showed significantly higher results for Vessel Diameter Index (VDI).
  • Both methods had similar noise level reduction but yielded inconsistent results overall, prompting the need for careful consideration of the chosen analysis technique in clinical applications.
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Introduction: Aniridia is a rare congenital panocular disease associated with varying degrees of visual acuity impairment.

Objective: To assess the experiences of congenital aniridia patients in Hungary, with visual impairment using a questionnaire developed by the ANIRIDIA-NET.

Patients And Method: Patients completed the Hungarian version of the 20-item ANIRIDIA-NET questionnaire with our assistance.

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Personalized spectacles customized according to an individual's facial anatomy were developed to provide enhanced visual performance and overall comfort when compared to standard spectacles. In this comparative crossover trial, each subject was randomly assigned to wear either personalized spectacles or standard spectacles for two weeks and then tried the second pair for another two weeks. Visual acuity and reading speed were measured, and visual quality and comfort were assessed using specific questionnaires.

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Our objective in this study was to analyze the aberrant neural regeneration activity in the cornea by means of in vivo confocal microscopy in systemic lupus erythematosus patients with concurrent dry eye disease. We examined 29 systemic lupus erythematosus patients and 29 age-matched healthy control subjects. Corneal nerve fiber density (CNFD, the number of fibers/mm) and peripheral Langerhans cell morphology were lower ( < 0.

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Article Synopsis
  • Congenital aniridia is a rare eye condition that affects almost all structures of the eye, often leading to poor vision, with various associated problems like keratopathy and glaucoma.
  • This study examined 65 eyes from 33 patients in Hungary, classifying corneal abnormalities using multiple staging systems including Mackman, Mayer, López-García, and Lagali.
  • The findings suggest using Lagali's staging due to its user-friendly format and effectiveness in monitoring disease progression and treatment planning.
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Purpose: Pilot study to evaluate adverse events and intraocular pressure (IOP)-lowering of a novel, noninvasive glaucoma procedure, femtosecond laser, image-guided, high-precision trabeculotomy (FLIGHT).

Design: Prospective, nonrandomized, single-center, interventional, single-arm clinical trial.

Participants: Eighteen eyes from 12 patients with open-angle glaucoma.

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Aim: To review existing data for the prevalence of corrected, uncorrected, and inadequately corrected refractive errors and spectacle wear in Hungary.

Methods: Data from two nationwide cross-sectional studies were analysed. The Rapid Assessment of Avoidable Blindness study collected population-based representative national data on the prevalence of visual impairment due to uncorrected refractive errors and spectacle coverage in 3523 people aged ≥50y (Group I).

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The aim of this study was to analyze the long-term outcome of first session of micropulse transscleral cyclophotocoagulation (MP-CPC) for refractory glaucoma developed after vitreoretinal surgery combined with silicone oil implantation. The inclusion criteria of this consecutive case series were: patients with secondary glaucoma in the refractory stage who underwent MP-CPC between 2018 and 2021, vitreoretinal surgery combined with silicon oil implantation, and at least a 24-month follow-up period after MP-CPC. Success was defined as the baseline eye pressure reduced at least 20%, and it should be ranged between 10 to 20 mmHg without further MP-CPC at the end of the follow-up.

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