Proteolytic activity in some freshwater animals and associated microflora in a wide pH range.

Proteolytic activity in some freshwater animals (crustacean plankton, sandhopper Amphipoda sp., larvae of chironomids Chironomus sp., oligochaetes Oligohaeta sp.

Influence of pH upon the activity of glycosidases and proteinases of intestinal mucosa, chyme and microbiota in fish.

It is shown that amylolytic and proteolytic activity of the intestinal mucosa, the chyme and the intestinal flora in the fishes, zander Zander lucioperca (L.), perch Perca fluviatilis L., bream Abramis brama (L.

[Sporobakterin impact on atherogenic dyslipidemia at patients with intestinal dysbacteriosis].

Unlabelled: The aim was to evaluate the correlation of intestinal microflora with indicators of lipid metabolism and the possibility of its correcting with sporobakterin.

Material And Methods: 38 patients from gastroenterological department (men - 18 women - 20, average age - 54,00 +/- 13,59 years), trapped in a random 5% sample. Were assessed the state of the luminal microflora in the large intestine and total cholesterol, b-lipoprotein (b-PL) and HDL in serum levels.

[Experience with movalis administration against osteoarthritis in Moscow clinics].

Aim: To test effectiveness of a new nonsteroid antiinflammatory drug movalis in osteoarthritis.

Materials And Methods: 113 patients aged 30-85 years from 8 Moscow clinics were treated with movalis. All the patients had long-standing osteoarthritis, 26 patients had concomitant gastric or duodenal ulcers.

[The scientific, organizational and methodological bases for the epidemiological surveillance of streptococcal group A infection in a large city].

These investigations have made it possible to establish the extent and scale of the spread of streptococcal infection (group A) and its socioeconomic importance in Moscow, a great mega-police of the world. The deterioration of the epidemiological situation in recent years, accompanied by an increase in morbidity and mortality caused by streptococcal infection, has been demonstrated. The program and conceptual foundations of epidemiological surveillance on this infection in Moscow are presented.

[Genotoxic effects of molybdenum and its derivatives in an experiment on Drosophila and mammals].

As a result of research it is established that molybdenum shows the most pronounced genetic activity at the early stages of spermatogenesis. Genetic effects of molybdenum and its modification by vitamin S are registered in the test of dominant lethal mutations. The cytogenetic activity of molybdenum, the molybdenic candle-end and its modification by antibacterial preparation have been revealed in the cells of mammalian marrow.

[Analysis of morphometric indices in mice for registration of induced mutations in germ cells].

The new-born mice of the first generation have been examined for changes in morphometric indices after the influence of fopurine, cyclophosphamide and cadmium chloride on their fathers. It is shown that fopurine and cyclophosphamide, the mutagens for mammals, increase the variability of morphometric indices. The method to calculate the morphometric indices of mice may be used for evaluating genetic risk of the compounds for man.

[The effect of the interferon inducer ridostin on photrin-induced mutagenesis in bone marrow cells in mice].

The number of aberrant metaphases was used to assess the influence of a highly active interferon inducer--ridostin, a two-spiral RNA, on spontaneous mutagenesis and that induced by an antitumor drug photrin. A new property of ridostin, viz. the antimutagenic effect, was established.

[A study of the dynamics of a contingent of patients with rheumatic diseases during ambulatory care (based on data from polyclinics in Moscow and the Moscow region)].

The analysis of the contingent of patients with rheumatic diseases taken under dispensary observation (DO) in 1985-1986 (625 persons) showed that in many polyclinics of Moscow and the Moscow region there took place substantial changes in the contingent of these patients and extension of its scope at the expense of inclusion of all nosological forms corresponding to the Regulation of the USSR Ministry of Health. Yet untimely detection and prophylactic medical examination of a great number of patients with rheumatic diseases (RD) was noted. Patients with deforming osteoarthrosis were not given due consideration.

[Genotoxic effects of heavy metals and their salts in an experiment on Drosophila and mammals].

Analysis of data on the influence of different metals (cadmium, cobalt, molybdenum) on the Drosophila melanogaster cells has revealed a considerable genotoxic effect of cadmium salts which manifests in the high percentage of cells elimination at the early stages of spermatogenesis--the premeiotic cells. The modifying effect of molybdenum in the combination with cadmium and molybdenum decreasing the percentage of the progeny fall may be induced by activation of the reparation systems. In the bone marrow cells of mice Cd ions modify cytogenetic effects of the AB preparation, intensifying its mutagenic activity in some cases.

[Manifestation of the mutagenic effect of acemidophen depending on its metabolism in various mammalian species (acemidophen--a promutagen)].

While studying the specific variability of metabolism of the fasciolacide anthelmintic acemidophen, it is found that it possesses no mutagenic activity. This activity is peculiar to its metabolite-free amine L2, formed in mice organism by deacetylation. Thus, acemidophen is shown to be promutagen.

[Modification of the cytogenetic effect of dioxidine in experimental alloxan diabetes in rats].

A dependence was established between the cytogenetic effect of dioxydinum antibacterial drug and the disturbance of carbohydrate metabolism in rats with alloxan diabetes.

[Cytogenetic effects of 1,4-dihydropyridine in various test systems].

Cytogenetic effect of 1,4-dihydropyridine was studied in different test-systems. The preparation is shown to decrease the level of complete sex-chromosome losses in Drosophila and chromosome aberration frequency in Allium fistulosum seedlings. The preparation does not affect spontaneous mutability of bone marrow cells in mice, high doses of the preparation have no mutagenic potential.

[Cytogenetic characteristics of 5 experimental mammalian pathology models].

A cytogenetic study of bone marrow cells was carried out first under conditions of toxic hepatopathy, experimental toxic nephropathy, alloxan diabetes in rats and under conditions of colibacillar and pyocyanic sepsis in mice in different periods of pathology. These experimental models may be used in research on medicinal mutagenesis.

[Reactive changes in autonomic synapses during frequency electric stimulation].

Reactive modifications of synapses of isolated intratrunkal vegetative neurones induced by high frequency orthodromal electric stimulation have been examined by vital phase-contrast microscopy, electron microscopy, vital staining with methylene blue in conjunction with concurrent electrophysiological control Flocculent aggregation of the synaptoplasma and vesicles has been discovered, which is associated with higher adhesiveness of modified proteins. There have been also discovered matrix translucence and rounding of the living synaptic buds, which is accounted for by segregation of the hydration fraction of the neuroplasma. The decrease in the number of light synaptic vesicles is accompanied by the appearance of osmiophilic, myelin-like bodies, dense-core vesicles and glycogen-like granules.

[Ultrastructural stereometry of highly differentiated transitional cell tumors of the bladder].

Cytomorphometric examination of the normal urothelium, 3 primary, 3 recurrent papillomas of the urinary bladder and 3 cancers of stage I indicated that average relative volumes of the nucleus and cytoplasm in their cells are nearly similar. Since these bolumes increase simultaneously in the tumors concerned, there is no change in the "nucleus-cytoplasm correlation" or "index" described above. Cytomorphometric indices of the nucleus and cytoplasma in papillomas are more close to those of high-differentiated cancer than of the normal urothelium.

[Mutagenic activity of dioxydine].

A previous evaluation of mutagenic activity of some drugs and perspective substances is carried out using indicator microorganisms. The mutagenicity of dioxydine, a drag with discovered antibacterial activity, is investigated. Dioxydine is shown to induce reversions in mutant of Salmonella typhimurium TA-1950, the indicator strain which demonstrates mutagenic activity of agents, producing mutations of base pair substitution type.

[Use of Allium fistulosum L. seeds as a preliminary test for studying mutagenic factors in the environment (drugs)].

The mutagenic activity was studied for the following 14 psychotropic drugs: aminazinum, fluphenazinum-decanoate, thioproperazinum, reserpinum, chlordiazepoxidum, diazepam, oxazepam, trioxazin, tavor, dipheninum, hexamidinum, benzonalum, carbamazepinum, ethosuximidium. It is shown that carbamazepinum, benzonalum, chlordiazepoxidum considerably increase the frequency of chromosome aberrations in the Allium fistulosum L. cells.

[Cellular ultrastructure of developing conglomerates of fresh water sponges].

The fine structure of cells of the conglomerates formed after dissociation of tissues of fresh-water sponges has been studied. In the development of the conglomerates of Ephydatia fluviatilis an important role is played by amoebocytes and choanocytes. In amoebocytes the shape of the nucleus, the mitochondria structure, the Golgi complex and endoplasmic reticulum have been found to change.