Folic acid-functionalized and acetyl-terminated dendrimers as nanovectors for co-delivery of sorafenib and 5-fluorouracil.

Molecular dynamics (MD) simulations were employed to investigate the simultaneous association of sorafenib (SF) and 5-fluorouracil (5-FU) with generation 4 (G4) acetyl-terminated poly(amidoamine) (PAMAM) dendrimers conjugated with folic acid (G4ACE-FA). Simulations were conducted under physiological (pH 7.4) and acidic (pH < 5) conditions, representing the environments of healthy and cancerous cells, respectively.

Performance assessment of the MOF adsorbent MIL-101 for removal of gaseous benzene and toluene: kinetic column modeling and simulation studies of fixed-bed adsorption.

The adsorbent MIL-101, a metal-organic framework material, was synthesized, characterized, and tested for removal of relatively low concentrations of benzene and toluene adsorbates (200 ppm) from a gas phase in a continuous flow system. Breakthrough studies were modeled based on Thomas, Yoon-Nelson, Yan, Clark, Bohart-Adams, bed-depth service time, modified dose response, Wolborska, and Gompertz in the continuous fixed-bed operation. Through statistical analysis, it was determined which type of regression is most suitable for the studied models, linear or nonlinear.

Isotherm, kinetic, and thermodynamic studies for dynamic adsorption of toluene in gas phase onto porous Fe-MIL-101/OAC composite.

In the present paper, micro-mesoporous Fe-MIL-101/OAC composite using in situ incorporation of Fe-MIL-101 into oxidized activated carbon was synthesized and characterized by XRD, FT-IR, SEM, EDS, and BET techniques. The adsorption performances of toluene onto adsorbents in the gas phase were studied using a laboratory-scale dynamic adsorption system under moist ambience. The toluene adsorption capacity of Fe-MIL-101/OAC composite and Fe-MIL-101 were 127 and 97.

Stability of beta-lactoglobulin A in the presence of sugar osmolytes estimated from their guanidinium chloride-induced transition curves.

The stabilizing role of Trehalose, Sucrose, Sorbitol and Mannitol as sugar osmolytes and polyols on beta-lactoglobulin A (beta-lgA) against its chemical denaturation at pH 2.0 and 25 degrees C has been explored by means of UV-vis spectroscopy. It has been observed that DeltaG (D) (o) of beta-lgA in the presence of 10% (w/v) Trehalose, Sucrose, Sorbitol and Mannitol is increased.