Experimental and Theoretical Approaches to Monitor the Behavior of Bovine Liver Catalase in Interaction with a Binuclear Bismuth Complex.

Here, the antioxidant potency of a binuclear Bi(III) complex {[Bi(μ-ox)(dipic)(HO) (taa)].HO, where ox = oxalato, dipic = pyridine 2,6-dicarboxylato, and taa = thiourea} was evaluated using the •DPPH assay. It was demonstrated that the Bi complex exhibited a high ability to inhibit DPPH free radicals.

Effect of Cu(II) compound containing dipicolinic acid on DNA damage: a study of antiproliferative activity and DNA interaction properties by spectroscopic, molecular docking and molecular dynamics approaches.

A polymeric compound formulized as [Cu(µ-dipic){Na(µ-HO)].2nHO (), where dipic is 2,6-pyridine dicarboxylic acid (dipicolinic acid, Hdipic), was synthesized by sonochemical irradiation. The initial cytotoxic activity of this complex compared with renowned anticancer drugs like cisplatin, HCT116 colon cell lines, shows promising results.

Tracking the binding site of anticancer drug fluxoridin with Fe-related proteins to achieve intelligent drug delivery.

In cancer cells that need a lot of iron for growth and metastasis, halo-transferrin (TF-containing iron) enters the cell with the help of the transferrin receptor 1 (TFR1) protein. If the anticancer drug can bind to the iron site by interacting with apo-transferrin (iron-free FT), it can enter the cancer cell by the same mechanism. Two iron-related proteins, Bovine liver catalase (BLC) and apo-Transferrin (TF), that are important in cancer patients were selected and their interaction with the anti-cancer drug Floxuridine (FUDR) was investigated.

Probing the combination of erlotinib hydrochloride, an anticancer drug, and human serum albumin: Spectroscopic, molecular docking, and molecular dynamic analyses.

Human serum albumin (HSA) is a globular and monomeric protein in plasma that transports many drugs and compounds. Binding of some drugs to HSA can lead to changes in its stability and biological function. We investigated the binding interactions between erlotinib hydrochloride (Erlo) and HSA.

Synthesis and crystal structure of a new heteronuclear complex of Fe(iii)-K designed to produce effective catalysts for CO hydrogenation.

A new paramagnetic heteronuclear complex formulated as [KFe(μ-ox)(HO)] (1), where ox is oxalate, has been synthesized under hydrothermal condition. The molecular structure of complex 1 was characterized by elemental analysis, Fourier-transform infrared spectroscopy (FT-IR) and single-crystal X-ray diffraction (SCXRD). The results of SC-XRD analysis revealed that complex 1 crystallizes in the centrosymmetric space group P2/c of a monoclinic system with cell dimension a = 7.

Comparative study on the anticancer activities and binding properties of a hetero metal binuclear complex [Co(dipic)Ni(OH)]·2HO (dipic=dipicolinate) with two carrier proteins.

Recognizing of binding mechanisms between drugs and carrier proteins is basic for us to understand the pharmacokinetics and pharmacodynamics of them. In this research, the anticancer activities of a binuclear complex [Co(dipic)Ni(OH)]·2HO (dipic=dipicolinate) against MDA-MB-231 cell lines were studied. Results of MTT assay and flow cytometry analysis revealed that above complex can induce the cytotoxicity and the apoptosis in breast cancer cell lines.