Induction of Apoptosis and Growth-Inhibition by Thymoquinone in ACHN and GP-293 Cell Lines in Comparable with Cis-Platinum.

Objective: In the current work, we investigated the cytotoxic and apoptotic effects of Thymoquinone (TQ), an active compound of Nigella sativa (N. sativa) and Cis-platinum, on normal renal epithelial (GP-293) and human renal adenocarcinoma cell lines (ACHN).

Methods: GP-293 and ACHN cell lines were cultured in Dulbecco's modified Eagle's medium (DMEM) with 10% Fetal bovine serum (FBS) and 1% penicillin plus streptomycin antibiotic.

Renoprotective Effect of Against Proteinuria and Apoptosis Induced by Adriamycin in Rat.

Objective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of ), the aim of this study was to determine the effects of hydroalcoholic extract of on ADR- induced nephropathy in rats.

Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + (600 and 1200 mg/kg) and (1200 mg/kg).

Doxorubicin-induced renal inflammation in rats: Protective role of .

Objective: The aim of the present study was to evaluate the possible protective effect of () extract against doxorubicin (DXR)-induced renal inflammation in rats.

Materials And Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7 day of the experiment.

Protection Against Doxorubicin-induced Nephropathy by Plantago major in Rat.

Introduction: Nephropathy is an important side effect of doxorubicin. The aim of the current study was to investigate the protective effect of Plantago major extract against doxorubicin-induced functional and histological damage in rat's kidney.

Materials And Methods: Sixty Albino rats were randomly divided into 6 groups.

Renoprotective Effect of Plantago Major Against Nephrotoxicity and Oxidative Stress Induced by Cisplatin.

Introduction: The aim of this study was to investigate the possible renoprotective effect of Plantago major extract against cisplatin-induced nephrotoxicity in rats.

Materials And Methods: Rats were divided into 6 groups. The first group was the control, group 2 was treated with cisplatin (7 mg/kg, single dose), and groups 3 to 6 received cisplatin with vitamin E (100 mg/kg) and Plantago major  extract at doses of 300 mg/kg, 600 mg/kg, and 1200 mg/kg, for 20 days.