Background: This case series summarizes our observations of hemolytic reactions after the administration of large amounts of intravenous immune (gamma) globulin (IVIG).
Study Design And Methods: Cases of hemolysis were identified by a decrease in hemoglobin not otherwise explained following IVIG administration.
Results: Sixteen cases were identified over a 2 1/2-year period at the Ottawa Hospital of approximately 1000 patients receiving IVIG (1.