Publications by authors named "Zohaer Muttalib"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease that progressively damages motor neurons in the central nervous system, leading to muscle weakness and eventual paralysis.
- The FDA has approved seven medications for ALS treatment, including Qalsody, Relyvrio, and Radicava, each with unique mechanisms to alleviate symptoms and slow disease progression.
- Despite available treatments, finding a cure for ALS is still very challenging, highlighting the need for ongoing research to better understand the disease and develop effective therapies.
This literature review explores the pivotal roles of the Uncoordinated-13 (UNC13) protein family, encompassing UNC13A, UNC13B, UNC13C, and UNC13D, in the pathogenesis of various human diseases. These proteins, which are evolutionarily conserved and crucial for synaptic vesicle priming and exocytosis, have been implicated in a range of disorders, spanning from neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) to immune-related conditions such as familial hemophagocytic lymphohistiocytosis (FHL). The involvement of UNC13A in neurotransmitter release and synaptic plasticity is linked to ALS and FTD, with genetic variations affecting disease progression.
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