Publications by authors named "Zoghbi W"

Background: Limited data exist on the long-term impact of beta-blocker therapy after percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) and preserved left ventricular ejection fraction (LVEF).

Objectives: The aim of the study was to evaluate the effects of early beta-blocker initiation vs no initiation following PCI in patients with stable CAD and preserved LVEF.

Methods: This retrospective cohort study employed target trial emulation and incident user design, utilizing the TriNetx database (2009-2024).

View Article and Find Full Text PDF

Purpose To investigate the determinants and effect of right ventricular (RV) dysfunction in aortic regurgitation (AR) using cardiac MRI. Materials and Methods This study included patients with moderate or severe AR who were enrolled in the DEBAKEY-CMR registry between January 2009 and June 2020. Patients with previous valve intervention, cardiomyopathy deemed unrelated to AR, severe aortic stenosis, and other confounders were excluded.

View Article and Find Full Text PDF

Background: Limited data exist on the risk profile and prognosis of young patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). This study sheds light on the burden of cardiovascular risk factors and outcomes in this population.

Methods: The Houston Methodist Young ACS-PCI registry is a retrospective analysis of young adults (18 to 50 years) undergoing PCI for ACS between 2010 and 2022.

View Article and Find Full Text PDF

Background: Transcatheter aortic valve replacement (TAVR) for high surgical risk patients with severe native aortic regurgitation (AR) presents unique challenges. Dedicated devices such as the JenaValve (JenaValve Technology) and J-Valve (JC Medical Inc) show promising results in addressing these challenges.

Objectives: This study compares the safety and efficacy of dedicated vs off-label devices among high surgical risk patients with pure native AR.

View Article and Find Full Text PDF

Background: The impact of mitral annular calcification (MAC) on the clinical outcomes of patients undergoing mitral transcatheter edge-to-edge repair (MTEER) remains unclear. This meta-analysis aims to evaluate the clinical outcomes of MTEER among patients with moderate to severe MAC compared to those with mild or no MAC.

Methods: We systematically searched PubMed, EMBASE, and Cochrane CENTRAL databases through March 31st, 2024, comparing clinical outcomes of MTEER among patients with moderate/severe (MAC+) versus no/mild MAC (MAC-).

View Article and Find Full Text PDF

Background: Guidelines for echocardiographic evaluation of aortic regurgitation (AR) have not been validated against an independent quantitative standard.

Objectives: The aim of this study was to evaluate the accuracy of the ASE (American Society of Echocardiography) AR guidelines against cardiac magnetic resonance (CMR) and to develop simplified approaches for detection of significant AR.

Methods: Patients with AR underwent echocardiography and CMR <4 hours apart.

View Article and Find Full Text PDF
Article Synopsis
  • The study explored the impact of residual transmitral mean pressure gradient (TMPG) after mitral transcatheter edge-to-edge repair (M-TEER) on patient outcomes, focusing on all-cause mortality and hospitalizations related to heart failure.
  • Higher baseline TMPG was found to predict increased residual TMPG post-procedure, with patients in the highest quartile experiencing significantly worse outcomes, including higher risks of mortality and heart failure hospitalization over three years.
  • The findings suggest that efforts should be made to minimize residual TMPG after M-TEER, particularly in patients with primary mitral regurgitation (MR).
View Article and Find Full Text PDF
Article Synopsis
  • PDS (post-pericardiotomy syndrome) can occur as a complication of pericardiocentesis.
  • Caution is advised when performing pericardiocentesis on effusions where the duration is unknown.
  • Using bedside transthoracic echocardiography (TTE) for regular assessments can help manage a careful and slow pericardiocentesis to reduce the risk of PDS.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the significance of measuring pulmonary venous flow (PVF) patterns during mitral transcatheter edge-to-edge repair (TEER) to predict patient outcomes, focusing on systolic dominant-PVF (SD-PVF) morphology.
  • Researchers analyzed data from 187 patients and found that those with SD-PVF had lower rates of severe residual mitral regurgitation (MR) and were less likely to experience all-cause mortality or heart failure hospitalization within one year.
  • The findings suggest that post-TEER PVF morphology could serve as an effective and straightforward prognostic tool, but more large-scale studies are needed to validate its impact further.
View Article and Find Full Text PDF

Aims: The concept of "atrial cardiomyopathy" (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using the term were sporadic until the decision was made to convene an expert working group with representation from four multinational arrhythmia organizations to prepare a consensus document on atrial cardiomyopathy in 2016 (EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication). Subsequently, publications on AtCM have increased progressively.

View Article and Find Full Text PDF

Background: Increased left atrial pressure (LAP) has been associated with adverse outcomes after mitral transcatheter edge-to-edge repair (M-TEER). We sought to evaluate outcomes based on differences in postprocedural LAP measured after the final clip deployment.

Methods: We included consecutive patients who underwent M-TEER at our institution between 2014 and 2022 with LAP monitoring.

View Article and Find Full Text PDF

Background: Coronary microvascular function and hemodynamics may play a role in coronary circulation and myocardial remodeling in patients with aortic stenosis (AS). We aimed to evaluate the relationship between myocardial blood flow and myocardial function in patients with AS, no AS, and aortic valve sclerosis.

Methods And Results: We included consecutive patients who had resting transthoracic echocardiography and clinically indicated positron emission tomography myocardial perfusion imaging to capture their left ventricular ejection fraction, global longitudinal strain (GLS), and myocardial flow reserve (MFR).

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to create a comprehensive registry of patients with Atherosclerotic Cardiovascular Disease (ASCVD) using automated data extraction to improve population health management and inform cardiovascular research.
  • A retrospective analysis was conducted on adult patients from June 2016 to December 2022, utilizing a common framework for extracting clinical data from electronic medical records (EMR) alongside social determinants of health.
  • A real-time registry was established containing extensive patient data, identifying 113,022 ASCVD patients, which allows for further analysis of their medical outcomes and treatment effectiveness.
View Article and Find Full Text PDF

Background: Pulmonary hypertension (PH) and secondary mitral regurgitation (MR) are associated with adverse outcomes after mitral transcatheter edge-to-edge repair. We aim to study the prognostic value of invasively measured right ventricular afterload in patients undergoing mitral transcatheter edge-to-edge repair.

Methods And Results: We identified patients who underwent right heart catheterization ≤1 month before transcatheter edge-to-edge repair.

View Article and Find Full Text PDF

Background: Prior studies investigating the impact of residual mitral regurgitation (MR), tricuspid regurgitation (TR), and elevated predischarge transmitral mean pressure gradient (TMPG) on outcomes after mitral transcatheter edge-to-edge repair (TEER) have assessed each parameter in isolation. We sought to examine the prognostic value of combining predischarge MR, TR, and TMPG to study long-term outcomes after TEER.

Methods And Results: We reviewed the records of 291 patients who underwent successful mitral TEER at our institution between March 2014 and June 2022.

View Article and Find Full Text PDF

Background: Cardiac magnetic resonance (CMR) was recently reported to predict mean pulmonary capillary wedge pressure (PCWP). However, there is a paucity of data on its accuracy for estimation of PCWP in patients with normal left ventricular (LV) ejection fraction (EF). We sought to examine its accuracy against the invasive gold standard and to compare it with the accuracy of comprehensive echocardiography.

View Article and Find Full Text PDF

In patients with significant cardiac valvular disease, intervention with either valve repair or valve replacement may be inevitable. Although valve repair is frequently performed, especially for mitral and tricuspid regurgitation, valve replacement remains common, particularly in adults. Diagnostic methods are often needed to assess the function of the prosthesis.

View Article and Find Full Text PDF