Pediatric Burden of Disease in the United States, 2015-2020.

Objective: To evaluate how the number of pediatric clinical trials, as a proxy for industry and National Institutes of Health (NIH) research priorities, compared with population-level burden of childhood disease in the United States (US).

Study Design: Cross-sectional study evaluating associations between initiated clinical trials funded by industry or the NIH and pediatric burden of disease in the US. Disease burden was measured as deaths, disability-adjusted life-years (DALYs), years of life lost (YLL), and years lived with disability (YLD).