Comparative in vitro study of calcium phosphate ceramics for their potency as scaffolds for tissue engineering.

Background: Calcium phosphate ceramics have been widely considered as scaffolds for bone tissue engineering. Selection of the best support for cultured cells, crucial for tissue engineered systems, is still required.

Objective: We examined three types of calcium phosphate compounds: α-tricalcium phosphate - the most soluble one, carbonate hydroxyapatite - chemically the most similar to the bone mineral and biphasic calcium phosphate - with the best in vivo biocompatibility in order to select the best support for osteoblastic cells for tissue engineered systems.

Physicochemical properties of the novel biphasic hydroxyapatite-magnesium phosphate biomaterial.

Besides high-temperature calcium phosphates (CaPs), low-temperature calcium phosphate bone cements (CPCs), due to excellent biological properties: bioactivity, biocompability and osteoconductivity, are successfully used as bone substitutes. However, some disadvantages, related mainly to their low resorption rate and poor mechanical properties result in limited range of applications of these implant materials to non-loaded places in the skeletal system. To overcome this problem, magnesium phosphate cements (MPCs) with high strength have been considered as biomaterials.

[Application of porous composite hydroxyapatite-TCP implants in orthopaedic surgery].

Bone grafts are the basic material in bone deficit filling. Due to difficulties to obtain bone grafts often the bone substitutes are used. Authors presents chemical, mineralogic and biologic properties of hydroxyapatite and ceramic material based on calcium phosphorate.