High-Resolution Array Comparative Genomic Hybridization Utility in Polish Newborns with Isolated Cleft Lip and Palate.

Cleft lip with or without cleft palate is one of the most common birth defects of unknown etiology. A fraction of its genetic causes is attributable to copy number variations detected by array comparative genomic hybridization. The value of array comparative genomic hybridization screening as a first-tier test in the newborn population with multiple congenital anomalies has now been accepted.

Surgical treatment of unilateral cleft lip and palate - own experience.

Aims: the aim of this paper is to present the final modification to a one-step operation of unilateral cleft lip and palate, together with a plaster-model representation of the shape of the palate in the 5th , 10th and 15th year of life of the patients treated at the Institute of Mother and Child. A modified one-step surgical technique for treating cleft lip and palate is presented.

Material And Methods: The study included 265 children and adolescents from the years 1980-2000.

Cephalometric outcome of two types of palatoplasty in complete unilateral cleft lip and palate.

In complete unilateral cleft lip and palate (CLP), a vomerplasty is assumed to improve midfacial growth because of the reduction in scarring in the growth-sensitive areas of the palate. Our aim, therefore, was to evaluate maxillofacial morphology after a modified Langenbeck technique or a vomerplasty in children with complete unilateral CLP who were operated on by a single surgeon. As part of a one-stage closure of complete unilateral CLP done during the first year of life, the technique for repair of the hard palate repair differed between the two groups.

Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate.

Aim: Malonyl-CoA is regarded as a key signaling molecule in mammalian cells. It is converted to acetyl-CoA, and to a lesser extent, to malonyl acid and malonylcarnitine (C3DC). Availability of carnitine has been reported to be essential for the developing fetus.

Craniofacial morphology in complete unilateral cleft lip and palate patients consecutively treated with 1-stage repair of the cleft.

Objective: To retrospectively evaluate the craniofacial morphology of children with a complete unilateral cleft lip and palate treated with a 1-stage simultaneous cleft repair performed in the first year of life.

Methods: Cephalograms and extraoral profile photographs of 61 consecutively treated patients (42 boys, 19 girls) who had been operated on at 9.2 (SD, 2.

Dental arch relationship in children with complete unilateral cleft lip and palate following one-stage and three-stage surgical protocols.

The objective of this study is to compare dental arch relationship following one-stage and three-stage surgical protocols of unilateral cleft lip and palate. Dental casts of 61 children (mean age, 11.2 years; SD, 1.

Dental arch relationship in children with complete unilateral cleft lip and palate following Warsaw (one-stage repair) and Oslo protocols.

Objective: To compare the dental arch relationship following one-stage repair of unilateral cleft lip and palate (UCLP) in Warsaw with a matched sample of patients treated by the Oslo Cleft Team.

Material: Study models of 61 children (mean age, 11.2; SD, 1.

Treatment outcome after one-stage repair in children with complete unilateral cleft lip and palate assessed with the Goslon Yardstick.

Objective: To compare results of Golson Yardstick measurement of dental arch relationships in a sample of 10-year-old Polish children with results of the Golson measurement in published reports.

Materials And Methods: Plaster models of 28 consecutively treated subjects with unilateral cleft lip and palate (UCLP) that was repaired with a one-stage simultaneous closure performed in the first year of life. All individuals were born between 1994 and 1995.

Nasolabial esthetics in children with complete unilateral cleft lip and palate after 1- versus 3-stage treatment protocols.

Purpose: Facial esthetics play an important role in social interactions. However, children with a repaired complete unilateral cleft lip and palate usually show some disfigurement of the nasolabial area. To date, few studies have assessed the nasolabial appearance after different treatment protocols.

[Preconceptional cigarette smoking and other risk factors for giving birth to a child with orofacial cleft].

Evidence suggests an association between orofacial clefts and maternal smoking, common cold, and stressful life events. 247 mothers of children with an orofacial cleft completed a self-administered survey with questions concerning obstetric history. Of these, 29.

Midfacial growth in a consecutive series of preadolescent children with complete unilateral cleft lip and palate following a one-stage simultaneous repair.

Objective: To evaluate midfacial growth in prepubertal children with complete unilateral cleft lip and palate following one-stage simultaneous repair.

Subjects: A series of 28 consecutively treated subjects with complete unilateral cleft lip and palate were compared with age- and gender-matched controls with normal midfacial structure.

Methods: On the lateral cephalograms taken at the age of approximately 10 years, size and position of the maxilla and upper dental arch were evaluated in vertical and horizontal planes.

Mandibular morphology and spatial position following one-stage simultaneous repair of complete unilateral cleft lip and palate.

Objective: To assess mandibular structure and spatial position following one-stage simultaneous repair of the unilateral cleft lip and palate.

Design: Forty boys and 17 girls with complete unilateral cleft lip and palate who underwent one-stage simultaneous repair of the cleft by the same surgeon at the age of 9.23 months (standard deviation = 1.

[Cephalometric evaluation of craniofacial symmetry in the complete unilateral cleft lip and palate patients following a one-stage simultaneous repair].

Aim: to compare the symmetry of craniofacial structure in complete unilateral cleft lip and palate patients following a one-stage simultaneous repair with non-cleft controls.

Materials And Methods: based on the cephalometric posterior-anterior x-rays craniofacial symmetry in 27 subjects with complete unilateral cleft lip and palate treated with one-stage simultaneous repair (mean time of repair--9th month of life) was assessed and compared with 60 non-cleft children. The age of the radiological evaluation in both groups approximated 10 years.

[Cephalometric evaluation of craniofacial morphology in preadolescent children with a repaired unilateral cleft of the primary palate].

Purpose: evaluation of craniofacial morphology in preadolescent subjects with a repaired cleft of primary palate.

Methods: 21 girls and 10 boys aged 11 years, with unilateral cleft of primary palate (14 with cleft lip and 17 with cleft lip and alveolus) were matched according to age and gender with subjects without cleft. Craniofacial morphology was evaluated based on performed cephalograms.

Cephalometric standards for Polish 10-year-olds with normal occlusion.

Objective: To establish gender-specific normative data for Polish children at the age of 10 years.

Materials And Methods: Thirty-nine boys and 34 girls (mean age 10.37, SD = 0.

[Craniofacial structure of 10-year-old children with complete unilateral cleft lip and palate following a one-stage simultaneous repair].

Aim: To determine the effects of a one-stage simultaneous repair of lip and palate upon the growth of craniofacial structures inpatients with complete unilateral cleft lip and palate (UCLP).

Material And Methods: This retrospective study involved 21 children who presented with non-syndromic complete unilateral cleft lip and palate and underwent a one-stage simultaneous closure performed by the same surgeon. 6 females and 15 males ranged in age from 6 to 12 months at the time of surgery (mean = 9.

[Morphology and spatial position of the mandible in complete unilateral cleft lip and palate individuals after one-stage repair of the cleft].

Aim: To compare the size and spatial position of the mandible in unilateral cleft lip and palate (UCLP) individuals treated with one-stage repair of the lip and palate, with normal individuals.

Material And Methods: 25 UCLP children aged 9-11 years, treated during the first year of life (average--9 months) compared with 25 subjects with normal morphology craniofacial skeleton. The measurements included: anterior and posterior facial height, mandibular plane angle, mandibular ramus, corpus and total length, Sella-Nasion-point B and Sella-Nasion-Pogonion angles.

[Long-term evaluation of width and length of the maxillary dental arch in unilateral cleft lip and palate children].

Aim: To compare the width and length of a maxillary dental arch in unilateral cleft lip and palate (UCLP) children treated during the first year of life with a one-stage repair of the lip and palate and a control group.

Material And Methods: 25 UCLP 10-12 years old subjects treated in the first year of life compared to 26 subjects with normal morphology of the dental arches. Intermolar and interpremolar widths and the length of the dental arch were measured.

[Oxidative DNA damage in mothers of children with isolated orofacial clefts].

Recently, there is increasing evidence suggesting that oxidative stress may contribute to birth defects. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is considered to be a sensitive biomarker of oxidative DNA damage. It would seem important to establish whether levels of 8-OHdG and antioxidants are different in mothers of children with orofacial clefts comparing to women who gave birth to healthy children.