Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues.

We have recently reported that a series of (E)-8-styrylcaffeines and (E)-2-styrylbenzimidazoles are moderate to very potent competitive inhibitors of monoamine oxidase B (MAO-B). The most potent member of the series was found to be (E)-8-(3-chlorostyryl)caffeine (CSC) with an enzyme-inhibitor dissociation constant (K(i) value) of 128 nM. In the present study, we have prepared additional caffeine and benzimidazole analogues in an attempt to identify compounds with improved MAO-B inhibition potency while still acting reversibly.

The syphilis-HIV interdependency.

Resurgence in the incidence of HIV and syphilis infections has been reported from all Western European Countries and the USA during the past years, the majority of them in men who have sex with men. The attitude among HIV-positive patients towards the application of preventive measures is changing in comparison to the time immediately after the detection of the HIV. Furthermore, HIV care providers do not always talk in an open manner about safer sex and disclosure, with the result that a large group of patients regards oral sex as harmless with respect to the transmission of sexually transmitted diseases (STDs).

Relationship of milk production, milk expected progeny difference, and calf weaning weight in angus and simmental cow-calf pairs.

Milk EPD, used to predict the milk production potential of a parent's daughters, have been reported by all major cattle breed associations. Our objectives were to determine the relationship of milk EPD of a dam to actual milk production (both fluid and components) and offspring weaning weight. Angus (AN; n = 114) and Simmental (SM; n = 82) cows were machine-milked at approximately 60, 104, and 196 d postpartum after overnight calf removal.

Action of rHuEpo on mechanical membrane properties of red blood cells in children with end-stage renal disease.

By means of a micropipette aspiration technique mechanical membrane properties of RBC in ten uraemic children undergoing haemodialysis were compared to those of nine healthy children. In contrast to the healthy reference group (mu = 4.01 +/- 0.

Evaluation of indicators of erythropoiesis stimulated by recombinant human erythropoietin in renal anemia.

Recombinant human erythropoietin (rh-EPO) was administered to 11 anemic children with end-stage renal disease who were undergoing hemodialysis. Hematocrit (Hct), absolute reticulocyte count (retics), creatine concentration of red cells and erythrocyte density test (EDT) were chosen as indicators of rh-EPO effect on erythropoiesis. In the present report the first 9 weeks shall be presented in which all patients received an identical dosage of rh-EPO per kg body weight.

Nucleotide and glutathione status in erythrocytes of children undergoing chronic hemodialysis under erythropoietin treatment.

Recombinant human erythropoietin (rhEPO) used for the treatment of children with renal anemia is an effective stimulus of erythroid proliferation and differentiation. The increases of reticulocytes and of the hematocrit values give the possibility to renounce further blood transfusions in dialysis patients. There are no beneficial in vivo effects of rhEPO on the glutathione status and on the nucleotide contents of red blood cells.

[Effect of human uremic serum on the survival of fetal rat hepatocytes].

Children suffering from chronic renal insufficiency frequently show a liver cell damage. It is not clarified, whether this damage is caused immediately by chronic renal insufficiency. In the model of fetal rat hepatocytes, which were isolated by trypsin digestion, we have investigated the influence of normal and uremic serum on the lactate dehydrogenase release and the staining with trypan blue, respectively.

[The incidence of kidney diseases in a pediatric kidney dispensary].

400 children (141 boys and 259 girls) in a renal disease care system were analyzed regarding their most frequent diagnoses of renal diseases and their age and sex distribution. Furthermore, the familiary situation, the time of observation, the number of consultations and the frequency of morphological changes of the kidney and the urinary tract were examined. 72% of the children suffered from urinary tract infection and in 10% a glomerulopathy and in 5.

Influence of lasalocid level on forage intake, digestibility, ruminal fermentation, liquid flow and performance of beef cattle grazing winter range.

Three experiments were conducted to study the effects of lasalocid level on performance, intake, digestibility, ruminal fermentation and fluid flow of beef cattle grazing dormant, tallgrass prairie. In Exp. 1, 120 pregnant, mature beef cows of primarily Hereford breeding (avg wt = 471 kg) were randomly assigned to received 0, 100, 200 or 300 mg lasalocid X head-1 X d-1 in 1.

[Oral galactose loading in characterizing the elimination and metabolizing performance of the liver in chronic renal failure].

For characterising the elimination and metabolisation performance of the liver in chronic renal insufficiency the galactose load test was carried out. 9 children with healthy liver and kidneys, 35 children with chronic renal insufficiency (15 were conservatively treated = group 1, 20 were in the chronic haemodialysis programme = group 2) as well as 5 children after kidney transplantation were examined. In group 1 a normal blood galactose concentration was present.

[Subvesical urinary track obstruction in children as the cause of chronic renal failure].

The infantile stenosis of the vesical cervix is a rare disease, etiology and pathogenesis of which are controversial. If it is not treated it leads to uraemia. On the basis of a clinical material consisting of 8 patients clinic and course of the disease are discussed.