Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.

Autoimmune diseases such as systemic lupus erythematosus (SLE) display a strong female bias. Although sex hormones have been associated with protecting males from autoimmunity, the molecular mechanisms are incompletely understood. Here we report that androgen receptor (AR) expressed in T cells regulates genes involved in T cell activation directly, or indirectly via controlling other transcription factors.

Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68.

H2-O (human HLA-DO) is a relatively conserved nonclassical MHC class II (MHCII)-like molecule. H2-O interaction with human HLA-DM edits the repertoire of peptides presented to TCRs by MHCII. It was long hypothesized that human HLA-DM inhibition by H2-O provides protection from autoimmunity by preventing binding of the high-affinity self-peptides to MHCII.

Third-Party Intervention in Peer Victimization: Self-Evaluative Emotions and Appraisals of a Diverse Adolescent Sample.

African American, European American, Mexican American, and Native American adolescents (N = 270) described how they felt and appraised their own actions in response to a peer's victimization. Analyses compared times they had calmed victim emotions, amplified anger, avenged, and resolved conflicts peacefully. Adolescents felt prouder, more helpful, more like a good friend, and expected more peer approval after calming and resolving than after amplifying anger or avenging peers.