Publications by authors named "Zoe Stanley"
Interleukin-1 receptor (IL-1R)-associated kinases (IRAKs) are core effectors of Toll-like receptors (TLRs) and IL-1R in innate immunity. Here, we found that IRAK4 and IRAK1 together inhibited DNA damage-induced cell death independently of TLR or IL-1R signaling. In human cancer cells, IRAK4 was activated downstream of ATR kinase in response to double-strand breaks (DSBs) induced by ionizing radiation (IR).
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- IRAK proteins play a key role in the immune response but also activate in response to ionizing radiation (IR), leading to a protective anti-apoptotic effect in vertebrate cells.
- The activation of IRAK4 and IRAK1 occurs through a phosphorylation cascade independent of traditional immune receptors and results in IRAK1 being transported to the nucleus.
- This newly identified pathway involves detection of DNA damage and could be targeted to enhance the effectiveness of cancer treatments, particularly against tumor resistance to chemotherapy.
Objective: To examine the effectiveness of a new, six-session emotion regulation group intervention designed for the secondary care setting: The Emotional Resources Group (ERG).
Method: In this pilot study, participants were recruited by referral from secondary care mental health services. Forty-seven individuals participated in the study.