Publications by authors named "Zoe Stamoulis"

Aims/hypothesis: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly connected 'hub' cells, important for the propagation of intercellular Ca waves. Functional subpopulations have also been demonstrated in human beta cells, with an altered subtype distribution apparent in type 2 diabetes.

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Article Synopsis
  • The study explores the heterogeneous nature of beta cells in the pancreatic islet, highlighting how different subpopulations contribute uniquely to insulin secretion, especially in the context of type 2 diabetes.
  • It examines the role of the imprinted gene neuronatin (NNAT) in insulin synthesis and its expression patterns in both mice and human beta cells, suggesting that epigenetic changes may influence beta cell function.
  • Utilizing advanced techniques like single-cell RNA sequencing and proteomics, the research indicates that distinct beta cell populations emerge during embryonic development, regulated by DNA methylation processes.
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