Publications by authors named "Zoe SaSSmannshausen"

Determining the label to target ratio, also known as the degree of labeling (DOL), is crucial for quantitative fluorescence microscopy and a high DOL with minimal unspecific labeling is beneficial for fluorescence microscopy in general. Yet robust, versatile and easy-to-use tools for measuring cell-specific labeling efficiencies are not available. Here we present a DOL determination technique named protein-tag DOL (ProDOL), which enables fast quantification and optimization of protein-tag labeling.

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Introduction: Detailed analyses of genetic diversity, antigenic variability, protein localization and immunological responses are vital for the prioritization of novel malaria vaccine candidates. Comprehensive approaches to determine the most appropriate antigen variants needed to provide broad protection are challenging and consequently rarely undertaken.

Methods: Here, we characterized PF3D7_1136200, which we named Asparagine-Rich Merozoite Antigen (ARMA) based on the analysis of its sequence, localization and immunogenicity.

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Article Synopsis
  • * A total of 325 patients were sequenced, revealing 79 mutations across 11 different PAH-related genes, with the majority (65%) found in the BMPR2 gene.
  • * The findings highlight the importance of using a comprehensive gene panel that can identify a variety of PAH mutations, benefiting both heritable and idiopathic cases.
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