Synopsis of recent research by authors named "Zoe Magill"
- Zoe Magill's research focuses on the cGAS-STING pathway, investigating its role in immune responses triggered by cytosolic DNA and highlighting mechanisms involved in STING-mediated signaling and regulation.
- Recent findings indicate that IKKɛ can induce non-IFN immune responses through mechanisms similar to TBK1, emphasizing the complexity of STING-related immune activities beyond traditional type I interferon production.
- Magill's studies also reveal significant differences in STING-induced activation and cell death responses between mouse and human dendritic cells, which may explain the lack of successful outcomes in clinical trials for STING agonists despite promising murine model results.
