Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits.

Cattle occasionally develop brassica-associated liver disease (BALD) and photosensitisation when grazing turnip or swede ( spp.) forage crops. The liver toxin in these brassica varieties has yet to be discovered.

Investigating the cause of -associated liver disease (BALD) in cattle: Progoitrin-derived nitrile toxicosis in rats.

A large outbreak of liver toxicity in dairy cows that were consuming swede (rutabaga, ssp. ) crops in Southland and Otago, New Zealand in 2014 prompted the search for the toxin(s) responsible for brassica-associated liver disease (BALD). Analysis of swede plant material showed that the ultra-dominant glucosinolate was progoitrin.

Serum metabolomics using ultra performance liquid chromatography coupled to mass spectrometry in lactating dairy cows following a single dose of sporidesmin.

Introduction: Photosensitization is a common clinical sign in cows suffering from liver damage caused by the mycotoxin sporidesmin. This disease, called facial eczema (FE), is of major importance in New Zealand. Current techniques for diagnosing animals with subclinical sporidesmin-induced liver damage (i.