Adipocyte death, adipose tissue remodeling, and obesity complications.

Objective: We sought to determine the role of adipocyte death in obesity-induced adipose tissue (AT) inflammation and obesity complications.

Research Design And Methods: Male C57BL/6 mice were fed a high-fat diet for 20 weeks to induce obesity. Every 4 weeks, insulin resistance was assessed by intraperitoneal insulin tolerance tests, and epididymal (eAT) and inguinal subcutaneous AT (iAT) and livers were harvested for histological, immunohistochemical, and gene expression analyses.