Publications by authors named "Zoe Jacobson"
Article Synopsis
- Researchers face challenges in testing heart failure therapies due to the absence of culture systems that replicate the complexities of human heart tissue over time.
- The study introduces a novel culture method that keeps human and pig heart slices viable and functional for up to 6 days, utilizing specific medium conditions and electrical stimulation.
- The culture system successfully preserves important cellular functions and structures, allowing for the evaluation of new therapies and insights into heart muscle mechanics.
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motifs in an affinity-dependent manner, binding to strong canonical E-boxes at promoters and invading abundant weaker non-canonical E-boxes clustered at enhancers.
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