Publications by authors named "Zoe Hahn"
Article Synopsis
- - Researchers developed a new platform called graphene oxide antigen-presenting platform (GO-APP) to improve CAR T cell manufacturing, which is essential for effective cancer therapy.
- - GO-APP effectively mimics the interactions between T cells and antigen-presenting cells, promoting significant T cell proliferation while maintaining their effectiveness in targeting cancer.
- - The new system increased CAR T cell production over five times compared to standard methods and allowed T cells to produce their own interleukin-2, reducing dependency on external supplements for growth.
Article Synopsis
- Cancer immunotherapy using autologous CAR T cells is complicated by manufacturing and patient selection issues, but 'off-the-shelf' options like allogeneic CAR-NKT cells could simplify the process.
- Researchers developed a new method to produce high-yield IL-15-enhanced CAR-NKT cells that target multiple cancers, showing effectiveness in battling multiple myeloma and removing immunosuppressive cells from tumors.
- The CAR-NKT cells demonstrated a stable hypoimmunogenic profile, meaning they are less likely to cause harmful immune reactions, making them promising candidates for clinical use without severe side effects like graft versus host disease.
Background: Measles virus (MeV) is an important cause of acute febrile illness and pediatric mortality globally, with recent U.S. outbreaks associated with under-vaccination.
View Article and Find Full Text PDFHuman papillomavirus (HPV) types differ by geographic location and the ethnicity of the human host, which may have implications for carcinogenicity. HPV35 is one of the least frequently identified high-risk types in North America and Europe but was the most common high-risk HPV (hrHPV) infection in a cohort in rural Zimbabwe. Whole genome analysis is limited for HPV35; no such studies have been performed in Zimbabwe.
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