[Anaerobic-aerobic infection in acute appendicitis].

362 patients with acute appendicitis (AA) were examined. For microbiological diagnosis of aerobic and anaerobic nonclostridial microflora we used complex accelerated methods (including evaluation of gram-negative microorganisms in comparison with tinctorial-fermentative method of differential staining according to oxygen sensitivity of catalasopositive together with aerobic and cathalasonegative anaerobic microorganisms) as well as complete bacteriologic examination with determination of sensitivity of the above microorganism to antimicrobial remedies. High rate of aerobic-anaerobic microbial associations and substantial identity of microflora from appendicis and exudate from abdominal cavity was revealed, which evidenced the leading role of endogenous microorganisms in etiology and pathogenesis of AA and peritonitis i.

[The characteristics of oxolinic acid transport in the blood of dogs and monkeys when administered intramuscularly and perorally].

A possibility of testing oxolynic acid (OA) transport in blood of animals by its bactericidal effect was studied experimentally on macaques and non-pedigree dogs (intramuscular and peroral administration). Kinetics of accumulation and elimination of OA and its derivatives exhibiting bactericidal effect makes it possible to predict optimum scheme of using these drugs in prevention and treatment of radiation disease.

[An experimental study of the efficacy of enterosorbents in salmonellosis].

The effectiveness of enterosorbents (polymethylsiloxane used as enterosgel and activated charcoal) has been studied in experiments on white rats infected with low virulent Salmonella typhimurium strain N 79. As shown in this study, the use of sorbents normalizes the morphofunctional characteristics of the epithelium of the small intestine and decreases the degree of Salmonella colonization of the parietal layer in the lumen of the small intestine, causing the destruction of some adsorbed bacteria.

[An electron microscopic study of the interaction of bacterial intestinal microflora and rotavirus virions].

Transmission electron microscopy has revealed the capacity of rotaviruses for adsorption on Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis cells and the absence of such capacity with respect to Enterococcus faecalis, Lactobacillus casei and Edwardsiella tarda. Different degrees and a varying character of the adsorption of rotaviruses by the representatives of the opportunistic group of bacteria have been established, which may aggravate the course of rotavirus diarrhea due to the aggregation of viral particles. For the first time the phenomenon of the selective destructive adsorption of rotaviruses by E.

[The adhesion of pathogenic microflora on carbon sorbents].

The adsorbing activity of granulated carbonic sorbents SKN and KAU, as well as their oxidated forms, containing protogenic carboxylic and phenolic groups with respect to Shigella flexneri, Salmonella typhimurium, Escherichia coli, Streptococcus aureus and Pseudomonas aeruginosa pathogenic strains has been studied. As shown in this study, the process of interaction between microorganisms and carbonic sorbents has two stages. At the first stage the main role is played by long-distance electrostatic forces and at the second stage, by Van der Waals short-distance forces, as well as bonds formed between cell structures and surface groupings of carbonaceous materials.

[Preoperative enterosorption as a method for preventing postoperative complications in mechanical jaundice in cancer patients].

Enterosorption as component of preoperative preparation of patients with cancer-induced mechanical jaundice assured subsidence of intoxication, improvement in hepatic and renal functions, better postoperative course, lower rates of purulent and other postoperative complications and lower postoperative lethality.

[Use of immobilized lysozyme in the treatment of suppurative wounds of the soft tissues].

The use for local treatment in 45 patients with abscesses and phlegmons of lysozyme immobilized in polymethylsiloxane contributed to acceleration in wound cleaning of necrotic masses, active granulation and epithelization, reduction in duration of patients' treatment by 3-5 days.

[Changes in DNA and surface properties of peripheral blood leukocytes in monkeys after total gamma irradiation].

Changes of Macaca nemestrina and Rhesus blood DNA have been studied up to 5 days after the total uniform gamma-irradiation in doses 6.2 and 6.5 Gy.

[The antiradiation effect of the cytostatic ribamidil and the possible mechanisms of its action].

Ribamidil has a cytostatic effect on bone marrow cells and a radioprotective therapeutic action. Ribamidil favors CFUs proliferation and does not interfere with the process of CFUs migration.

[Sensitivity of Pseudomonas bacteria to iodopiron and dimexide determined by electron microscopy].

A structure of the pyocyanic bacterium culture was studied by the method of electron microscopy of native preparations and ultrafine sections of the cells, which contained in the quantity of 10(5)/ml of suspension, and were treated with iodopiron in the concentration of 93.75 mg/ml, 10% dimexide solution and their combination. The increase in damaging effect on bacteria of the combined use of chemopreparations permits to recommend their complex administration in local pyocyanic infection in burned patients.

[Study of general toxic properties and side effects of polymethylsiloxane and gentamicin immobilized on it].

A long-acting dosage form for local use of gentamicin immobilized on polymethylsiloxane, a silicon organic adsorbent was developed. It combined the antimicrobial spectrum of gentamicin and the local sorption-detoxication action of the matrix. In acute and chronic experiments on 5 species of laboratory animals it was shown that polymethylsiloxane had no general toxic action on the animals, no damaging action on their internal organs, did not affect their functions and the state of the biological fluids, had no pyrogenic or allergenic effect.

[Results of using autologous and demineralized allogeneic bone transplants in reconstructive operations on the mandible in children with the syndrome of the first and second branchial arches].

A comparative clinico-roentgenological assessment of results of transplantation of auto- and allogenic demineralized transplants in reconstructive operations on the mandible was made in 58 children with the syndrome of the first and second branchial arches aged from 1 to 14 years. It was found that the substitution of the transplants by a new bone tissue was developing similarly. Allogenic bone transplants have a number of advantages over autotransplants: a simpler treatment and modelling the absence of an additional trauma to the child and a shorter duration of the operation.

[Radioprotective properties of oxolinic acid].

Oxolinic acid was shown to produce a radioprotective effect on mice and a therapeutic radioprotective action on rats and hamsters. As to radioprotective efficiency, oxolinic acid is inferior to such known sulfur-containing agents as indolylalkylamines and alpha-adrenomimetics. But oxolinic acid has an important advantage over them, that is, the increase in radioresistance it induces persists for several hours.

[Surgical treatment of congenital bilateral cleft lip].

Operations were performed on 23 patients with bilateral cleft lips by the method of Mirault--Limberg--Kardozo. Five patients had bilateral symmetrical total cleft lips, eight patients had bilateral nonsymmetrical total cleft lips, ten patients had bilateral incomplete cleft lips. One-stage operations were used in 17 patients, two-stage operations--in six patients.

[Radioprotective activity of hypotensive preparations].

In experiments on (CBA X C57B1)F1 mice a study was made of the radioprotective efficiency of some hypotensive drugs. Hemiton administered in different ways, within a wide dose range and at different times before irradiation was shown to possess a pronounced protective action. The substitution of the acid residue in hemiton decreased its activity.