[Specific immunotherapy in patients with bronchial asthma hypersensitive to housedust mites].

An efficacy and effects of immunotherapy (IT) on skin and bronchial reactivity, and serum levels of some immunoglobulins in mite asthma patients were evaluated. A usefulness of some tests was assessed additionally. The studies were carried out on 37 asthmatics.

[Efficacy and tolerance of allergenic extracts Allergovit and Novo-Helisen depot in immunotherapy of allergic diseases].

The aim of this study was to evaluate the efficacy, tolerance and immunogenity of allergenic extracts: Allergovit and Novo-Hellisen depot (produced by Allergopharma--Germany), used for sIT in pollinosis and house dust mite allergy. The treatment was carried out on 40 patients for three years. The evaluation included the results of a physical examination, the score of symptoms from self-observations and the consumption of antiallergic medicines.

[Clinical evaluation of Polish allergen extracts Catalet C and Catalet D in patients with pollinosis].

The aim of this paper was to evaluate the clinical efficacy, individual tolerance and side effects of allergen extracts, a weed pollen vaccine Catalet C and a tree pollen vaccine Catalet D. The study was carried out on a group of 41 patients aged from 15 to 46 years in comparison with a placebo group (36 patients). A good tolerance, no serious side effects and a high clinical efficacy, manifested in diminution of pollinosis symptoms in more than 80% of patients was noted.

Further observations on subacute sclerosing encephalitis in adult hamsters: the effects of intranasal infections with Langat virus, measles virus and SSPE-measles virus.

Passage by i.c. inoculations of suckling hamsters enhanced the virulence for adult hamsters of Langat virus (TP21), neurotropic strain of measles virus (HNT) and SSPE-measles virus (HBS), not only for i.

The occurrence of vacuolated neurons in the brains of hamsters affected with subacute sclerosing encephalitis following measles or Langat virus infection.

Hamsters infected by the intranasal route with either hamster adapted Langat virus passaged at least 10 times in hamsters and the HNT strain of measles virus passaged 149 times in hamsters, developed subacute sclerotic lesions in the pyriform cortex, and beginning from 2 months after infection, were accompanied by neuronal vacuolation with ballooning of the cytoplasm, especially in parts of the brain in close proximity of the sclerotic lesions. The vacuolated neurons resembled those seen in scrapie, especially of sheep and goats, suggesting a similarity between the effects of slow and subacute viral infections.

The relationship between immunity and the pathology of the CNS of mice infected with the CVS strain of rabies.

The CVS strain of rabies was used both for the production of immunity and as a challenge virus. The immunity induced in mice irrespective of the route of inoculation, whether i.p.

Subacute sclerosing encephalitis in adult hamsters infected with Langat virus.

Langat virus, passaged i.c. twice in suckling hamsters, became virulent for adult hamsters and caused progressive subacute encephalitis with a high degree of mortality spread out over the period of 3 months that the animals remained under observation.

Encephalopathy in mice following inapparent Semliki Forest Virus (S.F.V.) infection.

The avirulent “A8” strain of S.F.V.

The pathogenesis of western equine encephalitis virus (W.E.E.) in adult hamsters with special reference to the long and short term effects on the C.N.S. of the attenuated clone 15 variant.

The pathogenesis of the virulent strain of western encephalitis virus was compared with that of the attenuated Clone 15 of the virus. The results of the work showed that the 2 strains replicated equally in the C.N.

A lethal respiratory infection of rabbits with a strain of Semliki Forest virus (SFV).

Rabbits were highly susceptible to the inhalation of the L10.H6 strain of SFV; the smallest amount of virus capable of infecting by this route killed the animals within 14 days. There were certain unusual features about the pathogenesis of this disease.

The persistence of louping ill virus in immunosuppressed guinea-pigs.

Louping ill virus proved to be pathogenic for young guinea-pigs, about 20 days old weighing about 150-180 g. In older guinea-pigs there was inapparent infection with virus replication in the brain and spleen, inflammatory lesions of encephalitis but without clinical signs or mortality. In non-immunosuppressed guinea-pigs virus replication was noted in the brain and spleen only during the first 5 to 7 days after infection.

Delayed onset of encephalitis in mice passively immunised against Semliki Forest virus.

After a delay of 2 to 10 weeks or longer, clinical encephalitis developed in 15 per cent of mice which were protected against the acute stage of Semliki Forest virus (SFV) infection by antiserum. Some of these mice had high titres of SFV in their brains together with lesions of acute encephalitis while the others had subacute lesions and no virus was detected. When brains of apparently healthy mice which had survived the acute stage of SFV infection were examined, 90 per cent appeared to be histologically normal, but residual lesions of encephalitis were found in most of the remainder.

Louping-ill and Semliki forest virus infections in the short-tailed vole Microtus agrestis (L.).

A large proportion of short-tailed voles survived i.c. and footpad inoculations of louping-ill virus and many developed neutralizing antibodies.

The effect of immunosuppression on viral encephalitis, with special reference to cyclophosphamide.

Cyclophosphamide altered not only the pathological picture of virus encephalitis, but also enhanced the invasiveness of viruses and produced fatal forms of disease to which monkeys were otherwise resistant. Normal patas monkeys infected either i.c.

The changes in cell organelles of neurons in the brains of adult mice and hamsters during Semliki Forest virus and louping ill encephalitis.

Although Semliki Forest virus and louping ill belong to 2 distinct serological groups of arboviruses, the general pattern of cellular changes and their mode of morphogenesis is similar. Severe changes in the mitochondria of neurons, leading to the formation of inclusion bodies have been described in both infections. The possible origin of globular bodies and of the intracytoplasmic membrane convolutions from mitochondria has been suggested.

Vervet monkey disease: studies on some physical and chemical properties of the causative agent.

Heat inactivation at 56° for 30 min. failed to inactivate completely the causative agent of vervet monkey disease. Higher temperatures or longer periods are required to bring about complete inactivation.

The pathology of experimental vervet monkey disease in hamsters.

Although lesions in the organs of hamsters resemble those of monkeys and guinea-pigs, the extension of the pathological process to the brain is a new feature, so far found only in hamsters. The brain lesions in the hamster consist of capillary proliferations, haemorrhages, microglial changes and very severe astrogliosis. Necrosis of the needle track in i.