A Report of a Case of Reactivation of Plaque Morphea After Sunlight Exposure and a Literature Review.

We present the case of a 61-year-old woman with a histopathologically confirmed diagnosis of plaque morphea. The disease began about four years ago with the appearance of a single oval sclerotic plaque located on the front surface of the right lower leg. After topical treatment, the plaque underwent reverse development.

Asynchronous bilateral male breast cancer. A rare case report.

We describe a rare case of asynchronous bilateral carcinoma of the mammary glands in a 66-year-old man. The patient was admitted to the Department of Dermatology and Venereology due to exacerbation of chronic eczema. During the examination, a 3×2-cm tumor with retraction of the mammilla was found in the right mammary gland.

Use of a novel indentometer to evaluate skin stiffness in healthy and diseased human skin.

Background: Mechanical behavior of the skin can be evaluated by different non-invasive methods. In this study, we applied a new measurement device based on indentometry to determine the skin mechanical properties in healthy individuals and in patients with systemic sclerosis (SSc).

Material And Methods: Three studies were performed.

Onychomadesis in a COVID-19 patient.

We report the case of a 67-year-old woman who developed onychomadesis on 9 of her fingers 2 months after recovering from COVID-19, with subsequent full nail regrowth after 4 months. The development of onychomadesis in COVID-19 is probably related to inhibition of nail proliferation due to fever, direct viral damage, or an inflammatory process associated with endothelial damage and obliterative microangiopathy in the nail matrix area. Clinicians should be aware of nail changes and actively seek them out in patients with COVID-19.

Use of a novel Indentometer to evaluate skin induration in localized scleroderma and psoriasis vulgaris.

Introduction: Diseased skin in localized scleroderma (LS) and plaque psoriasis (PPs) is characterized by induration that can be evaluated by non-invasive bioengineering methods. In this study, we applied a new measurement device based on indentometry to determine the changes of skin mechanical properties in patients with LS and PPs.

Material And Methods: A total of 30 sclerodermatous plaques in 12 patients with LS and 46 psoriatic plaques in 19 patients with PPs were measured with Indentometer IDM 800 (Courage + Khazaka, Cologne, Germany).

Application of a novel finger temperature device in the assessment of subjects with Raynaud's phenomenon.

Introduction: Finger skin thermometry is one of the most commonly used methods for evaluating the response of the digital vessels to cold stimulation. The aim of this study was to evaluate the applicability of a novel finger skin temperature device for performing cold-stimulation test (CST) in subjects with primary and secondary Raynaud's phenomenon (RP).

Methodology: A total of 155 consecutive subjects were studied.

Pharmacoeconomics of Bronchial Asthma.

Introduction: Pharmacoeconomics (PE) treats the problems of pharmacotherapy policy, drug marketing and reimbursement and clinical trials. It guides policy makers for effective health resources utilization and determines the profitability of the new drugs on the basis of their price, efficacy and benefits for society. Types of health costs and pharmacoeconomic analyses: In the current review the main types of health costs are discussed.

Stability of Frequent Exacerbator Phenotype in Patients with Chronic Obstructive Pulmonary Disease.

Background: At present, there is little information in Bulgaria regarding the rate and stability of frequent-exacerbation phenotype in COPD patients.

Aim: To study the rate and stability of frequent-exacerbation phenotype in COPD patients.

Materials And Methods: We followed up 465 COPD patients for exacerbations over a 3-year period.

Impact of Air Pollution and Outdoor Temperature on the Rate of Chronic Obstructive Pulmonary Disease Exacerbations.

Background: Environmental pollution can be one of the main risk factors for acute exacerbations of chronic obstructive pulmonary disease (COPD).

Aim: To study the relationship between air pollution, outdoor temperature and exacerbations of COPD.

Materials And Methods: COPD patients (n=1432) were followed up for one year.