[Efficacy and safety of microsurgery in patients with Gustilo ⅢC open fractures].

Objective: To analyze the clinical efficacy and safety of microsurgery in patients with Gustilo ⅢC open fractures.

Methods: A total of 64 patients with Gustilo ⅢC open fractures who were admitted to the hospital bewteen September 2018 and March 2022 were included, and divided into the observation group and the control group, with 32 cases in each one. In the observation group, there were 24 males and 8 females, aged from 29 to 42 years with an average of (36.

Identification and validation of a new prognostic signature based on cancer-associated fibroblast-driven genes in breast cancer.

Background: Breast cancer (BC), a leading malignant disease, affects women all over the world. Cancer associated fibroblasts (CAFs) stimulate epithelial-mesenchymal transition, and induce chemoresistance and immunosuppression.

Aim: To establish a CAFs-associated prognostic signature to improve BC patient outcome estimation.

Multigene testing panels reveal pathogenic variants in sporadic breast cancer patients in northern China.

Breast cancer, the most prevalent malignancy in women worldwide, presents diverse onset patterns and genetic backgrounds. This study aims to examine the genetic landscape and clinical implications of rare mutations in Chinese breast cancer patients. Clinical data from 253 patients, including sporadic and familial cases, were analyzed.

PER3 plays anticancer roles in the oncogenesis and progression of breast cancer via regulating MEK/ERK signaling pathway.

Background: The study aimed at exploring the expression of period circadian regulator 3 (PER3), a major member of the circadian clock gene family, and its biological function in breast cancer.

Methods: PER3-silencing and PER3-overexpression cell lines were established by transfecting with pGenesil1-PER3 and Lenti-blast-PER3 vector, respectively.

Results: The results showed that the expression of PER3 was downregulated in breast cancer tissues and cell lines ( p < 0.

A novel prognostic signature based on immune-related genes of diffuse large B-cell lymphoma.

Diffuse large B-cell lymphoma (DLBCL) presents a great clinical challenge and has a poor prognosis, with immune-related genes playing a crucial role. We aimed to develop an immune-related prognostic signature for improving prognosis prediction in DLBCL. Samples from the GSE31312 dataset were randomly allocated to discovery and internal validation cohorts.

LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1.

Background: Breast cancer is a familiar malignant tumor, which is a great threat to women's life. Long noncoding RNA Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) has been reported to be associated with numerous cancers. This study aimed to explore the role of OIP5-AS1 and the mechanism of its action in the progression of breast cancer.

Gold Nanorods Combined with an Near Infrared Laser for the Establishment of a Precise Posttraumatic Osteoarthritis Model.

: To investigate the innovative application of gold nanorods combined with a laser in posttraumatic osteoarthritis (PTOA) modeling and to discuss the possible mechanisms. : Electron microscopy was used to characterize the gold nanorods. Cell counting kit-8 assay and enzyme-linked immunosorbent assay were used to evaluate cell proliferation and cytotoxicity.

Surgical exposures of the distal humeral fractures: An anatomical study of the anterior, posterior, medial and lateral approaches.

Purpose: Exposure of the articular surface is the key to the successful treatment of intra-articular fractures of distal humerus. Anterior, posterior olecranon osteotomy as well as medial and lateral approaches are the four main approaches to the elbow. The aim of this study was to compare the exposure of distal articular surfaces of these surgical approaches.

[Effect of primary neck-shaft angle after operation on the treatment of proximal humerus fracture by locking plate].

Objective: To explore the effect of postoperative initial neck stem angle on the treatment of proximal humeral fractures with locking plate.

Methods: From June 2014 to Septembetr 2016, 62 patients with proximal humeral fractures underwent internal fixation with locking plates were retrospectively analyzed, including 29 males and 33 females with an average age of(55.95±9.

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome.

Aluminum (Al) recognized as a persistent environmental contaminant is associated with bone diseases. Nicotinamide mononucleotide (NMN) is an intermediate of nicotinamide adenine dinucleotide (NAD) biosynthesis widely used to replenish NAD. Increasing evidences demonstrated that replenishment of NAD can protect against bone loss.

True compression of pelvic fractures under lateral impact.

Purpose: To promote the understanding of pelvic fracture mechanism and make more accurate evaluation of maximal deformity at the moment of fracture, kinematic response of pelvis to lateral impact and the difference between peak and final displacement were investigated.

Methods: A total of three human cadaver pelves were seated uprightly on a sled test table, explored to horizontal lateral impact by a 22.1-kg impactor at a speed of 5.

Exchangeability of FITC-SiO₂ Nanoparticles Between Cancer Cells Increases the Range of Drug Delivery.

Drug delivery system studies aim to improve nanoparticle (NP) formulation to enable efficient delivery of NPs to tumors. However, NPs must be transported by blood or through direct injection. How NPs leave the circulatory system and how NPs diffuse into a tumor remain unclear, and this uncertainty is a limitation of drug delivery systems.

Inhibition of cancer cell migration with CuS@ mSiO-PEG nanoparticles by repressing MMP-2/MMP-9 expression.

The metastasis of cancer cells is a vital aspect of disease progression and therapy. Although a few nanoparticles (NPs) aimed at controlling metastasis in cancer therapy have been reported, the NPs are normally combined with drugs, yet the direct therapeutic effects of the NPs are not reported. To study the direct influence of NPs on cancer metastasis, the potential suppression capacity of CuS@mSiO-PEG NPs to tumor cell migration, a kind of typical photothermal NPs, was systemically evaluated in this study.

Meta-analysis of the association between three microRNA polymorphisms and breast cancer susceptibility.

Single nucleotide polymorphisms (SNPs) in three microRNAs (miRNAs), rs2910164 in miR-146a, rs11614913 in miR-196a2, and rs3746444 in miR-499, have been associated with breast cancer (BC) susceptibility, but the evidence is conflicting. To obtain a more robust assessment of the association between these miRNA variants and BC risk, we carried out a meta-analysis through systematic literature retrieval from the PubMed and Embase databases. A total of 9 case-control studies on rs2910164, 12 on rs11614913, and 7 on rs3746444 were included.

Is adjuvant chemotherapy necessary for patients with microinvasive breast cancer after surgery?

Objective: Survival and treatment of patients with microinvasive breast cancer (MIBC) remain controversial. In this paper, we evaluated whether adjuvant chemotherapy is necessary for patients with MIBC to identify risk factors influencing its prognosis and decide the indication for adjuvant chemotherapy.

Methods: In this retrospective study, 108 patients with MIBC were recruited according to seventh edition of the staging manual of the American Joint Committee on Cancer (AJCC).

[Biomechanical study on repairing distal tibiofibular syndesmosis injuries with artificial ligaments].

Objective: To investigate the biomechanical properties of artificial ligament in the treatment of injuries to distal tibiofibular syndesmosis so as to provide a scientific basis for clinical application.

Methods: Sixteen fresh ankle specimens were harvested from 8 normal fresh-frozen cadavers. The initial tests were performed on 16 intact specimens (group A) and then the distal tibiofibular syndesmosis injury models were made (group B); the distal tibiofibular syndesmosis was fixed with artificial ligament in 8 specimens (group C) and with cannulated lag screw in the other 8 specimens (group D).

[Experimental study on magnesium phosphate cement in fracture treatment].

Objective: To investigate the effect of magnesium phosphate cement (MPC) to fix fractures.

Methods: In vitro: fifty-four pairs of fresh pig femoral heads were made 1 cm2 fracture and divided into 6 groups (n=9 pairs ). MPC was used to agglutinate fracture of femoral heads at 100% humidity and at 25 degrees C, 37 degrees C respectively.