Glycosidase-activated HS donorsto enhance chemotherapy efficacy.

Hydrogen sulfide (HS) plays a critical role in cancer biology. Herein, we developed a series of glycosidase-triggered hydrogen sulfide (HS) donors by connecting sugar moieties (including glucose, galactose and mannose) to COS donors via a self-immolative spacer. In the presence of corresponding glycosidases, HS was gradually released from these donors in PBS buffer with releasing efficiencies from 36 to 67 %.

Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications.

Bacterial infection is a major threat to the health and life of humans due to the development of drug resistance, which is related to biofilm formation. Nitric oxide (NO) has emerged as an important factor in regulating biofilm formation. In order to harness the potential benefits of NO and develop effective antibacterial agents, we designed and synthesized a new class of NO hybrids in which the active scaffold benzothienoazepine was tagged with a nitroso group and further conjugated with quaternary ammoniums or phosphoniums.