SPI1CD68 macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies.

Background: Tumor-associated macrophages (TAMs) have been demonstrated to be associated with tumor progression. However, the different subpopulations of TAMs and their roles in gastric cancer (GC) remain poorly understood. This study aims to assess the effects of Spi-1 proto-oncogene (SPI1)CD68 TAMs in GC.

Timed sulfonylurea modulation improves locomotor and sensory dysfunction following spinal cord injury.

Traumatic spinal cord injury (SCI) results in immediate tissue necrosis and delayed secondary expansion of neurological damage, often resulting in lifelong paralysis, neurosensory dysfunction, and chronic pain. Progressive hemorrhagic necrosis (PHN) and excessive excitation are the main sources of secondary neural injury. Recent approaches to attenuate PHN by glibenclamide can improve locomotor function after SCI.

BiFeO/rGO nanocomposite with visible light photocatalytic performance for tetracycline degradation.

Bismuth-iron semiconductor materials have been widely studied in the photocatalytic field due to their excellent light responsiveness. Among them, the potential and mechanism regarding photocatalytic degradation of organic pollutants by BiFeO are seriously ignored. In this research, BiFeO/reduced graphene oxide (BFO/rGO) was successfully synthesized for tetracycline (TC) removal.

Corrigendum: PPy@FeO nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis.

[This corrects the article DOI: 10.3389/fbioe.2022.

The malignancy suppression and ferroptosis facilitation of BCL6 in gastric cancer mediated by FZD7 repression are strengthened by RNF180/RhoC pathway.

Background: B-cell lymphoma 6 (BCL6) is a transcription repressor that plays a tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism in gastric cancer (GC) remain unclear. Ferroptosis, a novel programmed cell death, is closely related to tumor development.

Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy.

Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve degeneration and serious neuropathic pain termed paclitaxel-induced peripheral neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do not eliminate PIPN, and no therapies are available for PIPN, despite numerous studies to uncover the mechanisms underlying the development/maintenance of this condition. Therefore, we aimed to uncover a novel mechanism underlying the pathogenesis of PIPN.

Corrigendum: Yu et al. PPy@FeO nanoparticles inhibit the proliferation and metastasis of CRC suppressing the NF-κB signaling pathway and promoting ferroptosis.

[This corrects the article DOI: 10.3389/fbioe.2022.

Initial clinical and experimental analyses of ALDOA in gastric cancer, as a novel prognostic biomarker and potential therapeutic target.

The effect of ALDOA, an important regulator of tumor metabolism and immune cell function, on gastric cancer (GC) immune infiltration has not been elucidated. Hence, we explored the feasibility of using ALDOA combined with immune molecular markers as novel prognostic or therapeutic targets for GC patients. Bioinformatic analyses were initially performed in multiple databases to assess the prognostic prediction values of ALDOA expression in GC.

Development and verification of a prognostic model for colon cancer on pyroptosis-related genes.

Recently, the role of pyroptosis in cancer has attracted people's attention, but its function in colon cancer remains unclear. This study aimed to construct a pyroptosis-related model that can effectively predict the prognosis of patients with colon cancer and explore the potential functions of pyroptosis-related genes. We identified 40 differentially expressed PRGs between colon cancer and normal colon tissues.

PPy@FeO nanoparticles inhibit the proliferation and metastasis of CRC suppressing the NF-κB signaling pathway and promoting ferroptosis.

Colorectal cancer (CRC) is one of the most common cancers of the digestive tract, and patients with advanced-stage cancer have poor survival despite the use of multidrug conventional chemotherapy regimens. Intra-tumor heterogeneity of cancerous cells is the main obstacle in the way to effective cancer treatments. Therefore, we are looking for novel approaches to eliminate just cancer cells including nanoparticles (NPs).

Analysis of Differential Diagnosis of Benign and Malignant Partially Cystic Thyroid Nodules Based on Ultrasound Characterization With a TIRADS Grade-4a or Higher Nodules.

Partially cystic thyroid nodules (PCTNs) are a kind of thyroid nodule with both solid and cystic components, and are usually misdiagnosed as benign nodules. The objective of this study was to determine the ultrasound (US) characterizations with a TIRADS Grade-4a or higher partially cystic thyroid nodules (PCTNs) which are associated with being malignant or benign. In this study, 133 PCTNs with a TIRADS Grade-4a or higher were enrolled; 83 were malignant and 50 were benign.

Risk of station 12a lymph node metastasis in patients with lower-third gastric cancer.

Background: Controversy over the issue that No. 12a lymph node involvement is distant or regional metastasis remains, and the possible inclusion of 12a lymph nodes in D2 lymphadenectomy is unclear. As reported, gastric cancer (GC) located in the lower third is highly related to the metastasis of station 12a lymph nodes.

Batch fluidized bed reactor based modified biosynthetic crystals: Optimization of adsorptive properties and application in fluoride removal from groundwater.

A batch fluidized bed reactor (BFBR) with modified biosynthetic crystals (MBC), derived from Pseudomonas sp. HXF1, was investigated for the treatment of the groundwater containing fluoride (F). Impacts of different hydraulic retention time (HRT), pH, and initial F concentration on F removal were examined and the maximum defluorination efficiency was recorded as 95.

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells.

ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancers. However, the underlying mechanisms remain largely unknown. In this study, we investigated the inhibitory effects of ADAMTS9 on gastric cancer (GC) cells.

Carbon to nitrogen ratios influence the removal performance of calcium, fluoride, and nitrate by Acinetobacter H12 in a quartz sand-filled biofilm reactor.

This study investigated the influence of different carbon to nitrogen (C/N) ratios on the bio-removal efficiency of aquatic pollutants like calcium (Ca), fluoride (F), and nitrate (NO-N) in a quartz sand-filled biofilm reactor (QSBR) to treat the low C/N wastewater using Acinetobacter sp. H12 at pH 6.50.

Simultaneous removal of calcium, fluoride, nickel, and nitrate using microbial induced calcium precipitation in a biological immobilization reactor.

In this research, an immobilized biofilm reactor was established for the simultaneous removal of calcium (Ca), fluoride (F), nickel (Ni), and nitrate (NO-N) by microbial induced calcium precipitation (MICP). The operating parameters of the reactor, hydraulic retention time (HRT: 4, 8, and 12 h), influent Ca concentration (36.0, 108.

Effects of a high body mass index on the short-term outcomes and prognosis after radical gastrectomy.

Purpose: This study aimed to investigate the effects of a high body mass index (BMI) on the outcomes of radical gastrectomy for gastric cancer.

Methods: We conducted a retrospective cohort study of 1729 patients with stage I to III gastric cancer who received open radical gastrectomy from February 2003 to August 2011. The patients were divided into 3 groups according to their BMI: a low BMI group (BMI < 18.

Heterotrophic nitrification and biomineralization potential of Pseudomonas sp. HXF1 for the simultaneous removal of ammonia nitrogen and fluoride from groundwater.

Pseudomonas sp. HXF1, a strain capable of heterotrophic nitrification, aerobic denitrification (HNAD), and biomineralization was identified and employed for the simultaneous removal of ammonia nitrogen (NH-N) and fluoride (F). It removed 99.

Isolation of biosynthetic crystals by microbially induced calcium carbonate precipitation and their utilization for fluoride removal from groundwater.

Biosynthetic crystals (BC) were prepared through microbially induced calcium carbonate precipitation (MICP) for fluoride (F) removal from the groundwater. Batch experiments were conducted to evaluate the fluoride adsorption capacity and the impacts of critical factors (organic matter, pH, initial fluoride concentration and BC dosage) on defluorination efficiency of BC. The maximum adsorption amount and defluorination efficiency were recorded as 5.

Distributed Robust Optimization Algorithms Over Uncertain Network Graphs.

This article investigates the robustness issues of a set of distributed optimization algorithms, which aim to approach the optimal solution to a sum of local cost functions over an uncertain network. The uncertain communication network consists of transmission channels perturbed by additive deterministic uncertainties, which can describe quantization and transmission errors. A new robust initialization-free algorithm is proposed for the distributed optimization problem of multiple Euler-Lagrange systems, and the explicit relationship of the feedback gain of the algorithm, the communication topology, the properties of the cost function, and the radius of the channel uncertainties is established in order to reach the optimal solution.

Study on the simultaneous removal of fluoride, heavy metals and nitrate by calcium precipitating strain Acinetobacter sp. H12.

The removal properties and mechanisms of fluoride (F) and nickel (Ni) were studied by biomineralizing bacteria (Acinetobacter sp. H12). The results showed that the removal ratio of F, Ca and Ni reached 75% (0.

RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells.

Ring finger protein 180 (RNF180) is an important member of the E3 ubiquitin ligase family. As a tumor suppressor gene, RNF180 is significantly associated with the prognosis of patients with gastric cancer (GC) and can inhibit the proliferation, invasion, and migration of GC cells. Signal transducer and activator of transcription 3 (STAT3) are considered one of the most common oncogenes in human cancers with a key role in GC progression.

Should the left gastric artery lymph node be considered as the predictive lymph node for extra-gastric lymph node metastases?

Background: To validate the prognostic impacts of the left gastric artery lymph node (No. 7 LN) metastasis and investigate whether the No. 7 LN metastasis should be considered as the predictive LN for extra-gastric LN metastases.

Preoperative radiotherapy improves overall survival of pT4 pancreatic ductal adenocarcinoma patients after surgical resection.

Objective: The aim of delivering radiotherapy for pancreatic ductal adenocarcinoma patients was to sterilize vessel margin, increase R0 resection rate and delay local progression. Whether preoperative radiotherapy could prolong overall survival of surgical candidates remained unknown.

Methods: Pancreatic ductal adenocarcinoma patients receiving radical resection from surveillance, epidemiology and end result database were enrolled.

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.

TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells without TMIE. TMIE binds to TMC1/2, and a TMIE mutation that perturbs TMC1/2 binding abolishes mechanotransduction.