Publications by authors named "Ziyue Yu"

In the food industry, functional ingredients derived from active substances of natural sources and microbiological resources are gaining acceptance and demand due to their beneficial health properties. However, the inherent instability of these constituents poses a challenge in utilizing their functional properties. Microencapsulation with dietary fibre as wall material technology offers a promising solution, providing convenient manipulability and effective safeguarding of encapsulated substances.

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Fibroblast activation protein-α (FAP) has emerged as a promising target in the field of radiopharmaceuticals due to its selective expression in cancer-associated fibroblasts (CAFs) and other pathological conditions involving fibrosis and inflammation. Recent advancements have focused on developing FAP-specific radioligands for diagnostic imaging and targeted radionuclide therapy. This perspective summarized the latest progress in FAP radiopharmaceutical development, highlighting novel radioligands, preclinical evaluations, and potential clinical applications.

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The aquatic ecosystem, a repository for various pollutants, has been identified as a crucial zone where microplastics (MPs) serve as vectors for antibiotics, facilitating their spread. Despite this, the influence of MPs on the toxicity of antibiotics remains a topic of debate. In this study, we conduct a global meta-analysis, examining 730 datasets from 29 laboratory studies.

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Article Synopsis
  • - Compounds were developed to enhance their ability to interact with PARP-1 by modifying their structure and lipophilicity. Assays showed that several compounds, especially [F]BIBD-300, displayed promising high-affinity properties worthy of further investigation.
  • - PET imaging indicated that [F]BIBD-300 showed lower nonspecific uptake and a better target-to-nontarget ratio compared to [F]FTT in both MCF-7 and 22Rv1 tumor models, suggesting it may be a more effective tracer for detecting PARP-1 in tumors.
  • - Unlike [F]FTT, which is primarily cleared through the liver, [F]BIBD-300 utilizes
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The enhanced adsorption of pollutants on biofilm-developed microplastics has been proved in many studies, but the ecotoxicological effects of biofilm-developed microplastics on organisms are still unclear. In this study, adult zebrafish were exposed to original microplastics, biofilm-developed microplastics, original microplastics absorbed with oxytetracycline (OTC), and biofilm-developed microplastics absorbed with OTC for 30 days. The intestinal histological damage, intestinal biomarker response, gut microbiome and antibiotic resistance genes (ARGs) profile of zebrafish were measured to explore the roles of biofilm in the effects of microplastics.

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Memristors are essential components of neuromorphic systems that mimic the synaptic plasticity observed in biological neurons. In this study, a novel approach employing one-dimensional covalent organic framework (1D COF) films was explored to enhance the performance of memristors. The unique structural and electronic properties of two 1D COF films (COF-4,4'-methylenedianiline (MDA) and COF-4,4'-oxydianiline (ODA)) offer advantages for multilevel resistive switching, which is a key feature in neuromorphic computing applications.

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By modifying the structures of targeted AR antagonists and tracers, novel compounds , , , , and BIBD-399 were designed and synthesized. In vitro inhibition experiments demonstrated that , , and BIBD-399 have high affinity for AR. and [F]BIBD-399 were successfully synthesized.

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[F]Gln-OSOF, [F]Arg-OSOF, and [F]FSY-OSOF were designed by introducing sulfonyl F-fluoride onto glutamine, arginine, and tyrosine, respectively. [F]FSY-OSOF can be prepared directly by sulfur F-fluoride exchange, while [F]Gln-OSOF and [F]Arg-OSOF require a two-step labeling method. Those tracers retain their typical transport characteristics for unmodified amino acids.

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Sulfonamides are widely used in the clinical and animal husbandry industry because of their antibacterial properties and low cost. However, Sulfonamides cannot be fully absorbed by human bodies or animals, 50 %-90 % will be discharged from the bodies, and enter waters and soils through a variety of ways, causing environmental harm. Phytoremediation as a green in situ repair technology has been proven effective in sulfonamides removal, but the underlying mechanisms are still a question that needs to be further studied.

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Biodiversity loss resulting from environmental pollution is a global concern. While interspecific interactions are central to ecology, the impact of environmental pollution on predator-prey interactions and its ecological consequences, such as extinction and biodiversity loss, remain unclear. To investigate the effects of antibiotic exposure on predation strength and the resulting ecological consequence, the Didinium-Paramecium was utilized as a predator-prey model and exposed to nitrofurazone or erythromycin, two common pollutants, respectively.

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It is well recognized that biofilms can biosorb and biotransform heavy metals in aquatic environments. However, the effects of extracellular polymeric substance (EPS) on inorganic arsenic (As) bioaccumulation and biotransformation in biofilms are still unrevealed and need to be investigated. In order to explore the above scientific issues, the As accumulation and speciation in EPS-containing or EPS-free biofilms and growth medium under As(V)/As(III) exposure conditions were measured.

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Fibroblast activation protein (FAP) is closely related to central nervous system diseases such as stroke and brain tumors, but PET tracers that can be used for brain imaging have not been reported. Here, we designed, synthesized, and evaluated F-labeled UAMC1110 derivatives suitable for brain imaging targeting FAP. By substituting the F atom for the H atom on the aromatic ring of compound UAMC1110, - were designed and prepared.

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Changes in land-use structure and pattern can affect both atmospheric CO concentrations and the terrestrial carbon budget. To explore the effects of non-uniformly distributed CO concentration on terrestrial carbon uptake under land-use changes, this study integrated global CO concentrations, Net Primary Productivity (NPP), and land-use data under historical period and SSP1-2.6, SSP2-4.

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Type 2 diabetes is the most common chronic disease for the elderly people. This disease is difficult to be cured and causes continued medical expenses. The early and personalized risk assessment of type 2 diabetes is necessary.

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Accurate quantification of amyloid beta (Aβ) plaques is an important indicator for Alzheimer's disease diagnosis and treatment. For this purpose, new highly sensitive Aβ tracers were designed by regulating the position and number of nitrogen atoms. A series of derivatives of florbetapir (AV45) containing different numbers and positions of atoms were synthesized and evaluated for in vitro affinity and in vivo biodistribution.

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Although predation risk exists under natural conditions, its role is usually ignored when evaluating the ecotoxicity of environmental contaminants, and the interaction between predation risk and antibiotic ecotoxicity is not yet clear. To investigate the nonconsumptive effects (NCEs) of predation on the ecotoxicity evaluation of antibiotics, the median lethal concentration (LC), relative population growth rate (RGR), and activities of three antioxidases were measured in the ciliate Paramecium jenningsi exposed to graded concentrations of the antibiotics nitrofurazone (NFZ) or erythromycin (ERY) in the presence or absence of a predator, i.e.

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In order to control antibiotic resistance genes (ARGs) diffusion in constructed wetlands, it is critical to explore the main factors influencing ARGs removal and understand its mechanism. Despite the fact that numerous studies have been conducted to determine the factors influencing ARGs removal by constructed wetlands in recent years, attempts to use published data and incorporate them into a comprehensive comparison and analysis are still limited. A framework for literature collection, data extraction and statistical analysis (LDS) was constructed in this study.

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Microplastics have been widely reported as carriers of antibiotics, yet studies investigating the combined ecotoxicology of microplastics and antibiotics on organisms is limited. In this study, different sized polystyrene plastics and oxytetracycline (OTC) were used to carry out a 30-day single and binary-combined exposure experiment of zebrafish, and the microplastics and OTC accumulation, liver histological alteration, biomarkers and transcriptomic response of zebrafish were evaluated. Our results indicated that 300 nm and 50 nm plastic particles increased the OTC accumulation in liver by 33.

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Governments around the globe are trying to find sustainable solutions for lessening pressure on natural resources and reducing carbon emissions. Daily household consumption of food, energy, and water has an impact on stocks of natural resources, environmental quality, and climate change. Households have significant potential for increasing conservation actions for efficient use of natural resources and greenhouse gas emissions.

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Accumulated evidence has demonstrated that microplastics and oxytetracycline (OTC) affect organisms, but few studies have investigated their combined effects on aquatic organisms. In this study, adult zebrafish (Danio rerio) were exposed to single and binary-combined contamination of micro-, nano-sized polystyrene plastics and OTC for 30 days, and the intestinal histopathology, gut microbiota and antibiotic resistance genes (ARGs) of zebrafish were measured. The results showed that the intestinal epithelial damage increase with the decrease of plastic sizes.

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[C]ER176 has adequate sensitivity to image the human brain translocator protein (TSPO) in all three genotypes by positron emission tomography (PET). However, its clinical application is limited by the short half-life of C (20.38 min).

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The abnormal expression of aromatase is associated with the occurrence and development of a variety of neurological diseases and tumors. A series of F-labeled and Ga-labeled potential aromatase-binding candidate compounds were designed and synthesized based on the structures of aromatase inhibitors. Competitive inhibition experiments in vitro and molecular docking showed that BIBD-069 and BIBD-071 have high affinity for aromatase.

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Wind erosion causes significant dust emissions in northwest China, resulting in large amounts of soil organic matter and nutrient losses. It has a significant impact on air quality, climate change, vegetation growth, and economic growth at the regional scale. In this work, the Weather Research Forecasting with Chemistry atmospheric chemical transport model was used to simulate the temporal and spatial processes of dust emissions in northwest China from 1980 to 2015.

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Dysfunction or decreased expression of synaptic vesicle glycoprotein 2A (SV2A) is closely related to the progression of neurodegenerative diseases and psychiatric disorders. The development of positron emission tomography (PET) tracers targeting SV2A can provide a strong imaging basis for the diagnosis and treatment of these diseases. Herein we report the synthesis of the novel radiotracer [F]BIBD-181 and its preclinical evaluation.

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High-purity insoluble dietary fiber from okara (okara-HPIDF) is a raw material with a potentially positive effect on colon health. However, the mechanisms of the effect are far from clear. In this study, okara-HPIDF and low-purity dietary fiber from okara (okara-LPDF) were fed to C57BL/6 mice with acute ulcerative colitis induced by DSS.

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