Self-Healing and Shear-Stiffening Electrodes for Wearable Biopotential Sensing and Gesture Recognition.

The achievement of flexible skin electrodes for dynamic monitoring of biopotential is one of the challenging issues in flexible electronics due to the interference of large acceleration and heavy sweat that influence the stability of skin-electrode interfaces. This work presents materials and techniques to achieve self-healing and shear-stiffening electrodes and an associated flexible system that can be used for multichannel biopotential measurement on the skin. The electrode that is based on a composite of silver (Ag) flakes, Ag nanowires, and polyborosiloxane offers an electrical conductivity of 9.

Comprehensive macro and micro views on immune cells in ischemic heart disease.

Ischemic heart disease (IHD) is a prevalent cardiovascular condition that remains the primary cause of death due to its adverse ventricular remodelling and pathological changes in end-stage heart failure. As a complex pathologic condition, it involves intricate regulatory processes at the cellular and molecular levels. The immune system and cardiovascular system are closely interconnected, with immune cells playing a crucial role in maintaining cardiac health and influencing disease progression.

Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway.

Exposure to environmental cadmium (Cd) is known to cause neuronal death and cognitive decline in humans. Ferroptosis, a novel iron-dependent type of regulated cell death, is involved in various neurological disorders. In the present study, Cd exposure triggered ferroptosis in the mouse hippocampus and in the HT22 murine hippocampal neuronal cell line, as indicated by significant increases in ferroptotic marker expression, intracellular iron levels, and lipid peroxidation.

Machine learning-based prediction model for distant metastasis of breast cancer.

Background: Breast cancer is the most prevalent malignancy in women. Advanced breast cancer can develop distant metastases, posing a severe threat to the life of patients. Because the clinical warning signs of distant metastasis are manifested in the late stage of the disease, there is a need for better methods of predicting metastasis.

Fully printed and self-compensated bioresorbable electrochemical devices based on galvanic coupling for continuous glucose monitoring.

Real-time glucose monitoring conventionally involves non-bioresorbable semi-implantable glucose sensors, causing infection and pain during removal. Despite bioresorbable electronics serves as excellent alternatives, the bioresorbable sensor dissolves in aqueous environments with interferential biomolecules. Here, the theories to achieve stable electrode potential and accurate electrochemical detection using bioresorbable materials have been proposed, resulting in a fully printed bioresorbable electrochemical device.

Formation of Conductive Epidermal Electrodes Using a Fully Integrated Flexible System and Injectable Photocurable Ink.

fabrication of wearable devices through coating approaches is a promising solution for the fast deployment of wearable devices and more adaptable devices for different sensing demands. However, heat, solvent, and mechanical sensitivity of biological tissues, along with personal compliance, pose strict requirements for coating materials and methods. To address this, a biocompatible and biodegradable light-curable conductive ink and an all-in-one flexible system that conducts injection and photonic curing of the ink as well as monitoring of biophysiological information have been developed.

A flexible wearable device coupled with injectable FeO nanoparticles for capturing circulating tumor cells and triggering their deaths.

Elimination of circulating tumor cells (CTCs) in the blood can be an effective therapeutic approach to disrupt metastasis. Here, a strategy is proposed to implement flexible wearable electronics and injectable nanomaterials to disrupt the hematogenous transport of CTCs. A flexible device containing an origami magnetic membrane is used to attract FeO@Au nanoparticles (NPs) that are surface modified with specific aptamers and intravenously injected into blood vessels, forming an invisible hand and fishing line/bait configuration to specifically capture CTCs through bonding with aptamers.

Stable and Dynamic Multiparameter Monitoring on Chests Using Flexible Skin Patches with Self-Adhesive Electrodes and a Synchronous Correlation Peak Extraction Algorithm.

Advances in wearable bioelectronics interfacing directly with skin offer important tools for non-invasive measurements of physiological parameters. However, wearable monitoring devices majorly conduct static sensing to avoid signal disturbance and unreliable contact with the skin. Dynamic multiparameter sensing is challenging even with the advanced flexible skin patches.

A two-stage super learner for healthcare expenditures.

Objective: To improve the estimation of healthcare expenditures by introducing a novel method that is well-suited to situations where data exhibit strong skewness and zero-inflation.

Data Sources: Simulations, and two real-world datasets: the 2016-2017 Medical Expenditure Panel Survey (MEPS); the Back Pain Outcomes using Longitudinal Data (BOLD).

Study Design: Super learner is an ensemble machine learning approach that can combine several algorithms to improve estimation.

Radiofrequency coil design for improving human liver fat quantification in a portable single-side magnetic resonance system.

Earlier diagnosis of nonalcoholic fatty liver disease (NAFLD) is important to prevent progression of the disease. Recently, a low-cost portable magnetic resonance (MR) system was developed as a point-of-care screening tool for in vivo liver fat quantification. However, subcutaneous fat may confound the liver fat quantification, particularly in the NAFLD population.

Susceptibility-weighted imaging at high-performance 0.5T magnetic resonance imaging system: Protocol considerations and experimental results.

The high-performance low-field magnetic resonance imaging (MRI) system, equipped with modern hardware and contemporary imaging capabilities, has garnered interest within the MRI community in recent years. It has also been proven to have unique advantages over high-field MRI in both physical and cost aspects. However, for susceptibility weighted imaging (SWI), the low signal-to-noise ratio and the long echo time inherent at low field hinder the SWI from being applied to clinical applications.

Ultrasonic-assisted extraction, fatty acids identification of the seeds oil and isolation of chemical constituent from oil residue of Belamcanda chinensis.

Belamcanda chinensis is a common garden herb. The extraction technology of B. chinensis seed oil (BSO) was optimized by ultrasonic-assisted extraction (UAE) method, the composition, relative content of main fatty acids and physicochemical properties of BSO were determined, and the isolation, identification and determination of chemical constituent in BSO residue (BSOR) were also investigated.

Hydrogen-Induced Dislocation Nucleation and Plastic Deformation of 〈001〉 and 〈11¯0〉 Grain Boundaries in Nickel.

The grain boundary (GB) plays a crucial role in dominating hydrogen-induced plastic deformation and intergranular failure in polycrystal metals. In the present study, molecular dynamics simulations were employed to study the effects of hydrogen segregation on dislocation plasticity of a series of symmetrical tilt grain boundaries (STGBs) with various hydrogen concentrations. Our study shows that hydrogen both enhances and reduces dislocation nucleation events from STGBs, depending on different GB structures.

Continuously Quantifying Oral Chemicals Based on Flexible Hybrid Electronics for Clinical Diagnosis and Pathogenetic Study.

Simultaneous monitoring of diverse salivary parameters can reveal underlying mechanisms of intraoral biological processes and offer profound insights into the evolution of oral diseases. However, conventional analytical devices with bulky volumes, rigid formats, and discrete sensing mechanisms deviate from the requirements of continuous biophysiological quantification, resulting in huge difficulty in precise clinical diagnosis and pathogenetic study. Here, we present a flexible hybrid electronic system integrated with functional nanomaterials to continuously sense Ca, pH, and temperature for wireless real-time oral health monitoring.

Magnetically Levitated Flexible Vibration Sensors with Surficial Micropyramid Arrays for Magnetism Enhancement.

Magnetically levitated vibration sensors possess wide frequency response ranges and high sensitivity. Compared with springs and cantilevers, the levitated magnet suffers no mechanical abrasion, allowing minimized mechanical fatigue after prolonged exposure to vibration. However, magnetic levitated sensors are mostly based on fully rigid components, which are difficult to match the soft and curvilinear surface of the biological tissues and machines.

Thermal Transfer-Enabled Rapid Printing of Liquid Metal Circuits on Multiple Substrates.

Low-cost, rapid patterning of liquid metal on various substrates is a key processing step for liquid metal-based soft electronics. Current patterning methods rely on expensive equipment and specific substrates, which severely limit their widespread applications. Based on surface adhesion adjustment of liquid metal through thermal transferring toner patterns, we present a universal printing technique of liquid metal circuits.

Study on the Hydrogen Embrittlement of Nanograined Materials with Different Grain Sizes by Atomistic Simulation.

Although hydrogen embrittlement (HE) behavior has been extensively studied in bulk materials, little is known about H-related deformation and the fracture of nanograined materials. In this study, H segregation and HE mechanisms of nanograined Fe with different grain sizes are unveiled, following the employment of classical molecular dynamics simulations. The H segregation ratio increased, but the local H concentration at the grain boundaries (GBs) decreased with decreases in the grain size at a given bulk H concentration.

Comparison of the Efficacy and Safety of Neuroendoscopic Endonasal Transsphenoidal Surgeries and Intracranial Endoscopic Pterional Approach in Resection of Tuberculum Sellae Meningiomas.

Objective: To compare of the efficacy and safety of neuroendoscopic endonasal transsphenoidal surgeries and intracranial endoscopic pterional approach in resection of tuberculum sellae meningioma.

Methods: From January 2014 to June 2021, 60 patients with tuberculum sellae meningioma diagnosed and treated in our hospital were enrolled and randomly divided into study group and control group. The tuberculum sellae meningioma was removed by neuroendoscopic endonasal transsphenoidal surgeries in the study group, while the intracranial endoscopic pterional approach was used in the control group.

A single-sided magnet for deep-depth fat quantification.

Early detection of fatty-liver disease is important before further aggravations of the disease, such as cirrhosis, can develop. In this study, we developed a low-cost, movable single-sided magnet for in vivo liver fat quantification. A gradient field of 73.

Water-Sintered Transient Nanocomposites Used as Electrical Interconnects for Dissolvable Consumer Electronics.

Rapid development of electronic technology shortens the development time for new products and accelerates the obsolescence of consumer electronics, resulting in the explosive growth of electronic waste that is difficult to recycle and hazardous to the environment and human health. Transient electronics that can dissolve in water may potentially be adopted to tackle the issues of electronic waste; however, promising approaches to yield large-scale and high-performance transient consumer electronics have not yet been developed. Here, the joint effect of galvanic corrosion and redeposition has been utilized to develop bimetallic transient nanocomposites, which can be printed and water-sintered to yield high-performance transient PCB circuits with excellent electrical conductivity and mechanical robustness.

Waste tire heat treatment to prepare sulfur self-doped char via pyrolysis and KFeO-assisted activation methods.

Waste tire was heat-treated to prepare sulfur self-doped chars via pyrolysis and activation processes. Pyrolytic waste tire chars were activated at different temperatures (600 °C, 800 °C, 1000 °C, and 1200 °C) with KFeO additive ratios (mass ratio of KFeO to char) being 0.5, 1, 2, and 3, respectively.

A Multichannel Flexible Optoelectronic Fiber Device for Distributed Implantable Neurological Stimulation and Monitoring.

Optical fibers made of polymeric materials possess high flexibility that can potentially integrate with flexible electronic devices to realize complex functions in biology and neurology. Here, a multichannel flexible device based on four individually addressable optical fibers transfer-printed with flexible electronic components and controlled by a wireless circuit is developed. The resulting device offers excellent mechanics that is compatible with soft and curvilinear tissues, and excellent diversity through switching different light sources.

EMPROVING outcomes: Evaluating the effect of an ultralung protective strategy for patients with ARDS treated with ECMO.

Objective: Since the initiation of an adult extracorporeal membrane oxygenation (ECMO) program at our institution, the program has managed well over 200 patients with ECMO in a 3-year time frame. While there is a plethora of research evaluating ECMO for acute respiratory distress syndrome (ARDS), few studies have evaluated the impact that ventilator management after cannulation might have on outcomes. We hypothesized that failure to properly protect the lungs after cannulation would lead to higher mortality.