Publications by authors named "Ziyuan Zhang"

Renal tubular epithelial cell injury is an important manifestation of chronic kidney disease (CKD). This study aims to explore the mechanism of astragaloside IV (AS-IV) in the treatment of UII-mediated renal tubular epithelial cell injury by integrating network pharmacology and experimental validation. BATMAN, SwissTarget-Prediction and ETCM data bases were used to screen the target proteins of AS-IV.

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Knowing the spatial pattern of critical wetland patches has an important significance for the restoration and protection of wetland ecosystems. However, the spatial pattern of critical wetland patches in coastal areas is not well understood, and its influencing factors are also unclear, especially in coastal areas. In this study, landscape indices were used to study the spatial pattern of the wetlands in the Hebei-Tianjin coastal area, North China.

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An important aspect of the pathophysiology of early brain damage (EBI) after subarachnoid hemorrhage (SAH) is inflammasome-mediated neuroinflammation. It has been demonstrated that C3aR activation exacerbates neuronal damage in a number of neurological disorders. This study aims to explore the role of C3a in activating the NLRP3 inflammasome and exacerbating neuroinflammation after SAH.

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The widespread use of counterfeit goods caused significant damage to economy, personal data security, and public health. There is an urgent need to develop innovative anticounterfeiting materials to enhance their performance. Anticounterfeiting labels based on responsive photonic crystals have been widely researched for the inherent difficulty in replicating the delicate structures and structure colors.

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Melioidosis is a serious infectious disease caused by the Gram-negative bacterium . Recently, Rab32-dependent immune vesicles emerge as a critical defense pathway to restrict the intracellular . However, can evade host immune vesicles and survive in the cytoplasm, although this mechanism is not well understood.

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The distribution patterns and accumulation mechanisms of plant and microbial residues, along with their potential contributions to soil organic carbon (SOC), remain subjects of considerable debate, particularly within drawdown areas affected by reservoir operation. In this study, surface soil samples (0-10 cm) were collected from three different elevations within the drawdown area of the Three Gorges Reservoir. Amino sugars and lignin phenols served as biomarkers for microbial residues and plant-derived materials, respectively.

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Article Synopsis
  • Aging negatively impacts memory and synaptic function due to disrupted calcium balance, primarily from overactive voltage-gated calcium channels (VGCC).
  • In older mice, reduced levels of the AMPAR regulatory protein TARPγ8 correspond to lower CaMKIIα activity and cognitive decline, suggesting TARPγ8 is critical for memory and synaptic transmission.
  • By inhibiting VGCC, researchers found that TARPγ8 and CaMKIIα levels increased in aged mice, and introducing human TARPγ8 in the hippocampus improved memory, highlighting its potential as a target for addressing age-related cognitive issues.
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Article Synopsis
  • Myopia, especially high myopia, is becoming more prevalent and is now a major cause of blindness worldwide, raising public health concerns.
  • Understanding the mechanisms behind myopia is a critical research priority, and using animal models is essential for investigating its development and related biological changes.
  • This review outlines various animal models and experimental methods for inducing myopia, highlighting key molecular pathways to help researchers choose suitable models and develop effective prevention strategies.
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Liquid biopsy provides a convenient and safer procedure for the diagnosis and genomic profiling of tumors that are inaccessible to biopsy by analyzing exfoliated tumor cells (ETCs) or tumor-derived cell-free DNA (cfDNA). However, its primary challenge lies in its limited accuracy in comparison to tissue-based approaches. We report a parallel single-ETC genomic sequencing (Past-Seq) method for the accurate diagnosis and genomic profiling of hard-to-biopsy tumors such as cholangiocarcinoma (CCA) and upper tract urothelial carcinoma (UTUC).

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Objective: To investigate the effects of astragaloside IV (AS-IV) on podocyte injury of diabetic nephropathy (DN) and reveal its potential mechanism.

Methods: In in vitro experiment, podocytes were divided into 4 groups, normal, high glucose (HG), inositol-requiring enzyme 1 (IRE-1) α activator (HG+thapsigargin 1 µmol/L), and IRE-1α inhibitor (HG+STF-083010, 20 µmol/L) groups. Additionally, podocytes were divided into 4 groups, including normal, HG, AS-IV (HG+AS-IV 20 µmol/L), and IRE-1α inhibitor (HG+STF-083010, 20 µmol/L) groups, respectively.

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Article Synopsis
  • - Mitophagy is crucial for maintaining healthy mitochondria by eliminating damaged ones, and researchers found that the bacteria Burkholderia pseudomallei exploit this process to survive inside host cells using a protein called BipD.
  • - BipD interacts with specific host proteins (KLHL9 and KLHL13) and recruits a ligase (CUL3) to promote mitochondrial ubiquitination, although these host proteins don't directly regulate infectious diseases.
  • - The study identifies IMMT as a key substrate for ubiquitination by the KLHL9/KLHL13/CUL3 complex, showing that a specific type of ubiquitination is necessary for starting mitophagy and reducing harmful mitochondrial reactive oxygen species (ROS).
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Objective: To explore the molecular mechanism of Astragaloside IV (AS-IV) in alleviating renal fibrosis by inhibiting Urotensin II-induced pyroptosis and epithelial-mesenchymal transition of renal tubular epithelial cells.

Methods: Forty SD rats were randomly divided into control group without operation: gavage with 5ml/kg/d water for injection and UUO model group: gavage with 5ml/kg/d water for injection; UUO+ AS-IV group (gavage with AS-IV 20mg/kg/d; and UUO+ losartan potassium group (gavage with losartan potassium 10.3mg/kg/d, with 10 rats in each group.

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Photobiomodulation (PBM) therapy uses light of different wavelengths to treat various retinal degeneration diseases, but the potential damage to the retina caused by long-term light irradiation is still unclear. This study were designed to detect the difference between long- and short-wavelength light (650-nm red light and 450-nm blue light, 2.55 mW/cm, reference intensity in PBM)-induced injury.

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Background: The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the efficacy of interleukin-4 (IL-4), a potential therapeutic agent, in promoting neuroprotection and axon regeneration of retinal ganglion cells (RGCs) as identified through whole transcriptome sequencing in an in vitro axon growth model.

Methods: A low concentration of staurosporine (STS) was employed to induce in vitro axon growth.

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Background: MDR Staphylococcus aureus infections, along with the severity of biofilm-associated infections, continue to threaten human health to a great extent. It necessitates the urgent development of novel antimicrobial and antibiofilm agents.

Objectives: To reveal the mechanism and target of cinacalcet as an antibacterial and antimicrobial agent for S.

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Zearalenone (ZEA), one of the usual mycotoxins, has been recognized in many areas and crops, posing a significant threat to the living organisms even to human beings. However, the mechanisms of locomotive defects remain unknown. Herein, zebrafish larvae was employed to investigate ZEA effects on developmental indexes, muscle and neural toxicity, apoptosis, transcriptome and motor behaviors of zebrafish larvae.

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Soil moisture (SM) directly controls the land surface energy partition which plays an important role in the formation of extreme weather events. However, its dependence on specific climatic conditions is not thoroughly understood due to the complexity of soil moisture effects. Here, we examine the relationship between SM and surface energy partitioning under different climate conditions, and identify the influence paradigms of soil moisture on surface energy partition.

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Melioidosis, a severe tropical illness caused by , poses significant treatment challenges due to limited therapeutic options and the absence of effective vaccines. The pathogen's intrinsic resistance to numerous antibiotics and propensity to induce sepsis during acute infections further complicate management strategies. Thus, exploring alternative methods for prevention and treatment is crucial.

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Ciprofloxacin (CIP) is a prevalent environmental contaminant that poses a high risk of antibiotic resistance. High concentrations of antibiotics can lead to the development of resistant bacteria with high fitness costs, which often face a competitive disadvantage. However, it is unclear whether low-cost resistant bacteria formed by exposure to sub-MIC CIP in the environment can evolve competitive mechanisms against sensitive Escherichia coli (SEN) other than stronger resistance to CIP.

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Article Synopsis
  • * Girls (13.0%) reported higher rates of abuse compared to boys (10.6%), with several individual, relationship, and community factors influencing these rates.
  • * It emphasizes the need for multilevel prevention strategies that target high-risk adolescents, educate families about abuse prevention, and enhance involvement from parents and communities.
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Axonal degeneration is a pathologic change common to multiple retinopathies and optic neuropathies. Various pathologic factors, such as mechanical injury, inflammation, and ischemia, can damage retinal ganglion cell (RGC) somas and axons, eventually triggering axonal degeneration and RGC death. The molecular mechanisms of somal and axonal degeneration are distinct but also overlap, and axonal degeneration can result in retrograde somal degeneration.

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To investigate the effect of astragaloside IV (AS) on podocytes pyroptosis in diabetic kidney disease (DKD). Forty male Sprague-Dawley rats were randomly divided into normal group ( = 10) and model group ( = 30). Rats in model group were intraperitoneally injected streptozotocin (60 mg/kg) for 3 days to induce DKD.

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Objectives: Because buprenorphine treatment of opioid use disorder reduces opioid overdose deaths (OODs), expanding access to care is an important policy and clinical care goal. Policymakers must choose within capacity limitations whether to expand the number of people with opioid use disorder who are treated or extend duration for existing patients. This inherent tradeoff could be made less acute with expanded buprenorphine treatment capacity.

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