Comparative effectiveness and safety of imported and domestic immune checkpoint inhibitors in China: A systematic review and pairwise and network meta-analyses.

Background: Multiple brands of immune checkpoint inhibitors (ICIs), including domestic and imported agents, have been approved as front-line therapy in China. However, little is known about the difference in efficacy and safety of these agents of different origins. This study aims to systematically compare the difference between National Medical Products Administration (NMPA) approved domestic and imported ICIs regarding their efficacy, safety, and price.

Contrast-Enhanced Computed Tomography-Based Machine Learning Radiomics Predicts IDH1 Expression and Clinical Prognosis in Head and Neck Squamous Cell Carcinoma.

Rationale And Objectives: Isocitrate dehydrogenase 1 (IDH1) is a potential therapeutic target across various tumor types. Here, we aimed to devise a radiomic model capable of predicting the IDH1 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) and examined its prognostic significance.

Materials And Methods: We utilized genomic data, clinicopathological features, and contrast-enhanced computed tomography (CECT) images from The Cancer Genome Atlas and the Cancer Imaging Archive for prognosis analysis and radiomic model construction.

Digital economy and the synergistic governance of pollutants and carbon emissions: Facilitation or obstruction?

As an emerging force enabling high-quality economic development, digital economy (DE) still requires further investigation regarding its impact on synergistic governance of pollutants and carbon emissions (SGPCE). This study examines the impact of DE on SGPCE using two-way fixed effects model, intermediary effect model, and spatial Durbin model using provincial panel data from 2011 to 2020. The research reveals that: (1) DE has a significant promoting effect on SGPCE.

Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration.

Background & Aims: Ectopic liver regeneration in the spleen is a promising alternative to organ transplantation for treating liver failure. To accommodate transplanted liver cells, the splenic tissue must undergo structural changes to increase extracellular matrix content, demanding a safe and efficient approach for tissue remodelling.

Methods: We synthesised sulphated hyaluronic acid (sHA) with an affinity for the latent complex of transforming growth factor-β (TGF-β) and cross-linked it into a gel network (sHA-X) via click chemistry.

Distinguishing the Vaccine Effectiveness of Inactivated BBIBP-CorV Vaccine Booster Against the Susceptibility, Infectiousness, and Transmission of Omicron Stains: A Retrospective Cohort Study in Urumqi, China.

Introduction: With COVID-19 vaccination rolled out globally, increasing numbers of studies have shown that booster vaccines can enhance an individual's protection against the infection, hospitalization, and death caused by SARS-CoV-2. This study evaluated the effectiveness of COVID-19 vaccine BBIBP-CorV booster against being infected (susceptibility), infecting others (infectiousness), and spreading the disease from one to another (transmission).

Methods: This retrospective cohort study investigated the close contacts of all officially ascertained COVID-19 confirmed cases in Urumqi, China between August 1 and September 7, 2022.

Does new-type urbanization curb haze pollution? A case study from China.

The rapid urbanization process has led to a high concentration of population and economic activities in urban space, thus leading to severe environmental pollution. The concept of new-type urbanization has been proposed in China to combat the pollution associated with urbanization. This study analyzes the interaction effect of new-type urbanization with land, industry, and technology on haze pollution, using Chinese provincial-level panel data, and employs a STIRPAT model with interaction terms for empirical testing.

Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer.

Although fine particulate matter (FPM) in air pollutants and tobacco smoke is recognized as a strong carcinogen and global threat to public health, its biological mechanism for inducing lung cancer remains unclear. Here, by investigating FPM's bioactivities in lung carcinoma mice models, we discover that these particles promote lung tumor progression by inducing aberrant thickening of tissue matrix and hampering migration of antitumor immunocytes. Upon inhalation into lung tissue, these FPM particles abundantly adsorb peroxidasin (PXDN) - an enzyme mediating type IV collagen (Col IV) crosslinking - onto their surface.

Research on Microstructure and Properties of AlSi10Mg Fabricated by Selective Laser Melting.

In order to obtain high-performance aluminum alloy parts fabricated by selective laser melting, this paper investigates the relationship between the process parameters and microstructure properties of AlSi10Mg. The appropriate process parameters are obtained: the layer thickness is 0.03 mm, the laser power is 370 W, the scanning speed is 1454 mm/s, and the hatch spacing is 0.

Haze management: is urban public transportation priority effective?

Public transportation is often considered as a green travel mode to alleviate the negative externalities such as traffic congestion and haze pollution generated from transport. However, is prioritizing urban public transportation actually conducive to haze emission reduction? In this study, considering special emphasis on the cumulative effect of haze, a dynamic panel model is constructed to analyze and quantify the impact of public transportation on haze pollution by using the data of 284 cities in China, and the heterogeneity of the impact in cities with different pollution levels is examined. Several interesting findings are derived from the empirical results.

Foreign direct investment, environmental regulation, and haze pollution: empirical evidence from China.

As China's economy continues to grow, more and more attention is being paid to environmental pollution issues, including haze pollution, which is the most prominent of the air problems. In order to alleviate the haze pollution problem while ensuring the normal operation of the economy, the government has adopted an environmental regulation policy along with the introduction of foreign direct investment. This study uses a fixed effects model and two-stage least squares to examine the correlation of foreign direct investment and environmental regulation to the haze pollution level by using the Chinese provincial panel data from 2008 to 2019.

O2-(2,4-dinitrophenyl) diazeniumdiolate derivative induces G2/M arrest via PTEN-mediated inhibition of PI3K/Akt pathway in hepatocellular carcinoma cells.

Objectives: The study aimed to investigate whether G2/M arrest caused by O2-(2,4-dinitrophenyl) diazeniumdiolate derivative (JS-K) was related to PTEN-mediated inhibition of PI3K/Akt pathway in hepatocellular carcinoma cells.

Methods: The cell apoptosis was detected by DAPI staining and Annexin V-FITC/PI dual staining. The cell cycle was analysed by PI staining.