Photodiodes Made of Cascade Perovskite Single Crystals with Passivation Layers for High-Energy-Resolution γ-ray Spectroscopy.

Lead halide perovskite single crystals (LHPSC) are promising for room-temperature γ-ray spectroscopy in radiation detection. While MA(CHNH)-based LHPSCs are the most straightforward and cost-effective to synthesize from solution, their performance in γ-ray spectroscopy is hindered by significant noise and ion migration at high bias, which degrades their energy resolution (ER). The work introduced an n-type/intrinsic/n-type photodiode incorporating passivation layers of MA-based LHPSCs, grown through solution-process epitaxial growth.

Semi-Supervised Learning With Heterogeneous Distribution Consistency for Visible Infrared Person Re-Identification.

Visible infrared person re-identification (VI-ReID) exposes considerable challenges because of the modality gaps between the person images captured by daytime visible cameras and nighttime infrared cameras. Several fully-supervised VI-ReID methods have improved the performance with extensive labeled heterogeneous images. However, the identity of the person is difficult to obtain in real-world situations, especially at night.

Caloric restriction, Sirtuins, and cardiovascular diseases.

Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases, have emerged as key regulators of cellular metabolism, stress responses, and the aging process, serving as energy status sensors in response to CR. However, the mechanism through which CR regulates Sirtuin function to ameliorate cardiovascular disease remains unclear.

Therapeutic potential of alternative splicing in cardiovascular diseases.

RNA splicing is an important RNA processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise RNA splicing is required for maintaining gene and cell function; however, mis-spliced RNA transcripts can lead to loss- or gain-of-function effects in human diseases. Mis-spliced RNAs induced by gene mutations or the dysregulation of splicing regulators may result in frameshifts, nonsense-mediated decay (NMD), or inclusion/exclusion of exons.

Effect of 3.5 % NaCl solution with different NaS concentrations on ultrasonic cavitation erosion behaviors of HVOF sprayed WC-Ni coatings.

In this article, the WC-10Ni coatings were fabricated by HVOF spray, then the ultrasonic cavitation erosion performances of the coatings in distilled water and 3.5 wt% NaCl solution with various NaS concentrations (0, 20 and 200 ppm) were investigated. The results of the cumulative volume loss of the coating in different mediums showed that the coating exhibited enhanced cavitation erosion resistance with the increase of NaS concentrations in medium.

Short-term effect of coil handle orientations on fMRI-guided rTMS on insomnia: A case report.

Introduction: The coil handle orientation plays a pivotal role in the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS). However, there is currently no consensus on the optimal individualized coil handle orientation, especially for non-motor areas.

Case Presentation: The present case reported a short-term effect of functional connectivity (FC)-guided rTMS with coil handle posterior-anterior 45° (PA45°) and posterior-anterior 135° (PA135°) on a patient with insomnia.

A Review on Wine Flavour Profiles Altered by Bottle Aging.

The wine flavour profile directly determines the overall quality of wine and changes significantly during bottle aging. Understanding the mechanism of flavour evolution during wine bottle aging is important for controlling wine quality through cellar management. This literature review summarises the changes in volatile compounds and non-volatile compounds that occur during wine bottle aging, discusses chemical reaction mechanisms, and outlines the factors that may affect this evolution.

Difference of ventricular synchrony between LBBP, LBFP and LVSP: A speckle tracking echocardiographic study.

Purpose: Left bundle branch area pacing (LBBAP) has emerged as a physiological and stable form of pacing. We aim to compare the mechanical ventricular synchrony of LBBP, LBFP, and LVSP.

Methods: Proximal Left bundle branch pacing (LBBP), left bundle fascicular pacing (LBFP) and left ventricular septal pacing (LVSP) were identified in patients with bradycardia who successfully underwent LBBAP.

Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study.

Background: Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris.

Objective: To evaluate the efficacy and adverse effects of M-PDT and ISO for moderate to severe acne vulgaris.

Methods: A multicenter, randomized clinical trial was conducted with participants randomly assigned to the M-PDT group (up to 5 weekly sessions following manual comedone extraction) or the ISO group (oral ISO, 0.

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence.

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without effective treatments. The current understanding of the pathogenesis of TAA is still limited, especially for sporadic TAAs without known genetic mutation.

Localized Surface Plasmon-Enhanced Infrared-to-Visible Upconversion Devices Induced by Ag Nanoparticles.

Upconversion devices (UCDs) have motivated tremendous research interest with their excellent potential and promising application in photovoltaic sensors, semiconductor wafer detection, biomedicine, and light conversion devices, especially near-infrared-(NIR)-to-visible upconversion devices. In this research, a UCD that directly turned NIR light located at 1050 nm into visible light located at 530 nm was fabricated to investigate the underlying working mechanism of UCDs. The simulation and experimental results of this research proved the existence of the quantum tunneling phenomenon in UCDs and found that the quantum tunneling effect can be enhanced by a localized surface plasmon.

Translation directionality and translator anxiety: Evidence from eye movements in L1-L2 translation.

While considerable research on the impact of anxiety on second language learning has been carried out in international contexts, the impact of anxiety on the translator's undertaking L2 translation, a sort of anxiety arising from the translation directionality, as well as the structure of cognitive mechanism for translational anxiety, remain under-explored. Adopting the eye-tracking and key-logging approach to data collection, this study implemented an eye-tracking experiment with EFL learners at a Chinese university to probe into how the participants responded to L1 and L2 translation-tasks and the mechanism involved in these processes. It is found that translation directionality does have a great impact on the processing of translation, which causes the change of cognitive load and then leads to the change of levels in translator anxiety.

[Prokaryotic expression and polyclonal antibodies preparation and identification of human focal adhesion kinase (FAK)].

Objective To Clone, express, and purify the focal adhesion kinase (FAK) gene C-terminal focal adhesion location sequence (aa798-aa1041), and to prepare and identify the rabbit anti-FAK polyclonal antibodies. Methods The C-terminal (2671 bp-3402 bp) gene of the FAK gene was amplified by PCR in vitro and cloned into pCZN1 vector to construct a pCZN1-FAK recombinant expression vector. The recombinant expression vector was transformed into E.

[Detection of IgG protein in human urine based on vertical flow paper microfluidic chip].

The kidney is the body's most important organ and the protein components in urine could be detected for diagnosing certain diseases. The amount of IgG protein in urine could be used to determine the degree of kidney function damage. IgG protein in human urine was detected by vertical flow paper-based microfluidic chip, double-antibody sandwich immunoreaction, and cell phone image processing.

HIV Disclosure Among Sexually Infected People Living with HIV and AIDS in China: Prevalence, Influencing Factors, and Negative Outcomes.

HIV disclosure is crucial for HIV prevention and control, but may also lead to discrimination, insult, and even violence against people living with HIV and AIDS (PLWHAs). In this study, we examined HIV disclosure, its influencing factors, and its association with intimate partner violence (IPV) among 1153 PLWHAs through the sexual route in Jinan, Shandong Province, China. Our results showed that 76.

Expansion of the multifunctionality in off-stoichiometric manganites using post-annealing and high pressure: physical and electrochemical studies.

Prospects for the use of manganites in various areas of modern technologies require comprehensive studies of their physical and chemical properties. LaMnO (LMO) ceramics have been synthesized at an annealing temperature of 1150 °C with further post-annealing at 1250, 1350, and 1450 °C. As increases, the structure symmetry changes, and both the crystallite size and chemical defects increase.

Aging in the sebaceous gland.

Sebaceous glands (SGs) originate from hair follicular stem cells and secrete lipids to lubricate the skin. The coordinated effects of intrinsic and extrinsic aging factors generate degradation of SGs at a late age. Senescence of SGs could be a mirror of the late aging of both the human body and skin.

RBDF: Reciprocal Bidirectional Framework for Visible Infrared Person Reidentification.

Visible infrared person reidentification (VI-REID) plays a critical role in night-time surveillance applications. Most methods attempt to reduce the cross-modality gap by extracting the modality-shared features. However, they neglect the distinct image-level discrepancies among heterogeneous pedestrian images.

Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis.

Background: TNF-α elicits a cascade amplification effect in psoriasis. Macromolecule drugs targeting TNF-α are widely used for the clinical treatment of psoriasis. However, there are currently no effective small-molecule inhibitors that can be used in the clinic.

Size and Shape's Effects on the High-Pressure Behavior of WS Nanomaterials.

Exploring the behavior of nanocrystals with varying shapes and sizes under high pressure is crucial to understanding the relationship between the morphology and properties of nanomaterials. In this study, we investigated the compression behaviors of WS nanotubes (NT-WS) and fullerene-like nanoparticles (IF-WS) by in situ high-pressure X-ray diffraction (XRD) and Raman spectroscopy. It was found that the bulk modulus of NT-WS is 81.

Comprehensive assessment of cellular senescence in the tumor microenvironment.

Cellular senescence (CS), a state of permanent growth arrest, is intertwined with tumorigenesis. Due to the absence of specific markers, characterizing senescence levels and senescence-related phenotypes across cancer types remain unexplored. Here, we defined computational metrics of senescence levels as CS scores to delineate CS landscape across 33 cancer types and 29 normal tissues and explored CS-associated phenotypes by integrating multiplatform data from ~20 000 patients and ~212 000 single-cell profiles.

Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy.

Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self-assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural killer (NK) cells by the oxidative metabolite of the selenopeptide is developed.