A pilot study of self-care education for psychotherapists.

Objectives: Existing research shows that psychotherapists may experience secondary trauma and burnout, often neglecting self-care. This study aims to examine the effectiveness of self-care education in enhancing self-care efficacy among psychotherapists and explore factors affecting improvements in their self-care abilities.

Methods: A self-care workshop was conducted for 159 psychotherapists from various fields.

Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury.

Obesity and nonalcoholic fatty liver disease (NAFLD) are established risk factors for drug-induced liver injury (DILI). The previous study demonstrates that benzbromarone (BBR), a commonly prescribed pharmaceutical agent for managing gout and hyperuricemia, exacerbates hepatic steatosis and liver injury specifically in obese individuals. However, the precise mechanism underpinning this adverse effect remains incompletely elucidated.

Construction and SHAP interpretability analysis of a risk prediction model for feeding intolerance in preterm newborns based on machine learning.

Objective: To construct a highly accurate and interpretable feeding intolerance (FI) risk prediction model for preterm newborns based on machine learning (ML) to assist medical staff in clinical diagnosis.

Methods: In this study, a sample of 350 hospitalized preterm newborns were retrospectively analysed. First, dual feature selection was conducted to identify important feature variables for model construction.

Stereoselective Synthesis of Maralixibat via VO(acac)/Schiff Base-Catalyzed Asymmetric Oxidation of Its Sulfide Intermediate.

The stereoselective synthesis of maralixibat was achieved by harnessing the chiral transferring effect of the stereogenic -sulfoxide functionality, which was obtained via the VO(acac)/Schiff base-catalyzed asymmetric oxidation of a phenylthiophenol prochiral intermediate. The -sulfoxide intermediate underwent a ring closure reaction to form the seven-membered ring core structure with the desired stereochemistry, ultimately ensuring the drug's exceptional isomeric purity and synthetic efficiency.

Superabsorbent starch protective layer modulates zinc anode interface for long-life aqueous zinc ion batteries.

Aqueous zinc ion batteries (AZIBs) have attracted much attention for their safety, low cost and high theoretical capacity. Nevertheless, Zn dendrites and the adverse reactions such as corrosion, hydrogen evolution and passivation on the anode affect the cycle life and stability of AZIBs. Herein, superabsorbent starch (SS) was employed on Zn foil to form an artificial interface protection layer, which inhibited the formation of dendrites by guiding the uniform deposition of Zn.

Asymmetric aza-Henry reaction toward trifluoromethyl β-nitroamines and biological investigation of their adamantane-type derivatives.

Amino acid-derived quaternary ammonium salts were successfully applied in the asymmetric aza-Henry reaction of nitromethane to -Boc trifluoromethyl ketimines. α-Trifluoromethyl β-nitroamines were synthesized in good to excellent yields with moderate to good enantioselectivities. This reaction is distinguished by its mild conditions, low catalyst loading (1 mol%), and catalytic base.

Targeting human progesterone receptor (PR), through pharmacophore-based screening and molecular simulation revealed potent inhibitors against breast cancer.

Breast cancer, the prevailing malignant tumor among women, is linked to progesterone and its receptor (PR) in both tumorigenesis and treatment responsiveness. Despite thorough investigation, the precise molecular mechanisms of progesterone in breast cancer remain unclear. The human progesterone receptor (PR) serves as an essential therapeutic target for breast cancer treatment, warranting the rapid design of small molecule therapeutics that can effectively inhibit HPR.

Covalent Organic Framework with 3D Ordered Channel and Multi-Functional Groups Endows Zn Anode with Superior Stability.

Achieving a highly robust zinc (Zn) metal anode is extremely important for improving the performance of aqueous Zn-ion batteries (AZIBs) for advancing "carbon neutrality" society, which is hampered by the uncontrollable growth of Zn dendrite and severe side reactions including hydrogen evolution reaction, corrosion, and passivation, etc. Herein, an interlayer containing fluorinated zincophilic covalent organic framework with sulfonic acid groups (COF-S-F) is developed on Zn metal (Zn@COF-S-F) as the artificial solid electrolyte interface (SEI). Sulfonic acid group (- SOH) in COF-S-F can effectively ameliorate the desolvation process of hydrated Zn ions, and the three-dimensional channel with fluoride group (-F) can provide interconnected channels for the favorable transport of Zn ions with ion-confinement effects, endowing Zn@COF-S-F with dendrite-free morphology and suppressed side reactions.

Identifying the impacts of trading construction waste across jurisdictions: a simulation of the Greater Bay Area, China, using non-linear optimization.

Local authorities worldwide are actively encouraging waste material trading within their jurisdictions as a promising strategy to develop a more circular economy. Construction activities consume natural resources intensively and generate massive solid waste. With proper ex-post treatment, the waste materials can be recycled or even directly reused, hence contributing to the circular economy.

Criterion of Grouting Pressure in Regional Advance Grouting Treatment to Prevent Water Disaster from Karst Aquifers in Coal Seam Floors.

The deep mining of coal mines in North China faces the serious threat of water inrush from karst aquifers in the coal seam floors, and regional advance grouting technology (RAGT) is an effective means to prevent and control such disasters. However, it is difficult to choose the grouting pressure during the implementation of RAGT, and excessive grouting pressure will lead to the splitting of karst fracture and reduce the grouting effect. In this study, based on the Bernoulli equation, the relationship between the ground grouting pressure and critical grouting pressure during grouting is established.

Fissure Grouting Mechanism Accounting for the Time-Dependent Viscosity of Silica Sol.

Subject to the complex hydrogeological environment where underground engineering is located, the grouting prevention and control of microfissure water ingress are increasingly strict. Silica sol grout has been increasingly used in field tests because of its fine particles and good injectability. Therefore, it is necessary to examine the time-dependent viscosity of silica sol grout and clarify its diffusion law in a rock fissure.

Spin-Seebeck effect and thermoelectric properties of one-dimensional graphene-like nanoribbons periodically embedded with four- and eight-membered rings.

The spin-Seebeck effect together with a high spin thermoelectric conversion efficiency has been regarded as one of the core topics in spin caloritronics. In this work, we propose a spin caloritronic device constructed on hydrogen-terminated sawtooth graphene-like nanoribbons periodically embedded with four- and eight-membered rings to investigate the thermal spin currents and thermoelectric properties by using density functional theory combined with the non-equilibrium Green's function method. Our theoretical results show that spin-Seebeck currents are induced by the temperature gradient between two leads due to two isolated spin-up and spin-down transport channels above or below the Fermi level.

Involvement of Expression in Hepatitis B Virus-Related Hepatocellular Carcinoma.

Objective: To investigate the expression of transient receptor potential (TRP) superfamily genes, especially in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC).

Methods: Three cancer samples of HBV-related HCC at phase IV and matched paracancerous liver tissues were included in the study. Total RNA was extracted, and differential expression of RNA was screened by high-throughput transcriptome sequencing.

Quantifying the embodied carbon saving potential of recycling construction and demolition waste in the Greater Bay Area, China: Status quo and future scenarios.

Comparing with the enduring efforts to reduce carbon emissions in design, construction, and operation stages of a construction project, less attention has been paid to emission abatement potential in the end-of-life stage, particularly by recycling waste generated by construction and demolition (C&D) activities. This research aims to cover this knowledge void by quantifying the embodied carbon saving potential of recycling C&D waste. It does so by adopting a Life Cycle Assessment (LCA) and choosing the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) in South China for a case study.