570 nm/770 nm light-excited deep-red fluorescence switch based on dithienylethene derived from BF-curcuminoid.

Developing dithienylethene (DTE)-based fluorescence switches triggered by biocompatible visible light has always been a long-term goal in view of their potential in numerous biological scenarios. However, their practical availability is severely limited by the short visible light (generally less than 500 nm) required for photocyclization, their inability to achieve red or near-infrared emission, and their short fluorescence lifetimes. Herein, we present a novel DTE derivative featuring a dimethylamine-functionalized BF-curcuminoid moiety (NBDC) by using an "acceptor synergistic conjugation system" strategy.

Blue-/near-infrared light-triggered photochromism in a reinforced acceptor-acceptor type dithienylethene with aggregation-induced emission.

The development of photochromic dithienylethene (DTE) derivatives activated by visible light, particularly those exhibiting aggregation-induced emission (AIE) properties, is highly sought after for applications in photoelectric functional materials and biological systems. In this study, we rationally designed and successfully synthesized a novel cyanostilbene- and nitro-functionalized DTE derivative (6) featuring a reinforced acceptor (A)-DTE-acceptor (A) structural motif. Each of the two cyanostilbene fragments bearing nitrobenzene groups imparts both electron-withdrawing effects and AIE characteristics, thereby ensuring efficient visible light-driven photochromic performance.

Aggregation-Induced Emission of Curcuminoid-BF Complex for Phosphor-Converted Red Light-Emitting Diode.

The incorporation of difluoroboron β-diketonate and tetraphenylethene under a facile Knoevenagel condensation reaction afforded one new D-π-A-π-D complex with high aggregation-induced emission (AIE) activity. The film can maintain a high photocurrent after long-term (500 min) photoelectronic measurements. The successful fabrication of a red LED device makes it a promising candidate for high-performance solid-state lighting.

The Role of CD4T Cells in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) has become the fourth leading cause of cancer-related deaths worldwide; annually, approximately 830,000 deaths related to liver cancer are diagnosed globally. Since early-stage HCC is clinically asymptomatic, traditional treatment modalities, including surgical ablation, are usually not applicable or result in recurrence. Immunotherapy, particularly immune checkpoint blockade (ICB), provides new hope for cancer therapy; however, immune evasion mechanisms counteract its efficiency.

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4T cell cytotoxicity through ESM1.

Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response. Uncovering the mechanism how cancer cells evade immune surveillance would help to develop new immunotherapy approaches and combination therapy. In this article, by analyzing the transcriptional factors which modulate the differentially expressed genes between T cell infiltration high group and low group, we identified oncoprotein B cell lymphoma 6 (BCL6) suppresses the infiltration and activation of tumor infiltrating T lymphocytes, thus correlated with poorer clinical outcome.

Synthesis, Crystal Structure, and Photophysical Properties of Bromothiophene-Functionalized BF-Curcuminoid as a Versatile Building Block.

A novel bromothiophene-functionalized BF-curcuminoid (BTC-BF) is synthesized by Knoevenagel condensation reaction. The structure of BTC-BF is determined by H-nuclear magnetic resonance (H NMR), C-nuclear magnetic resonance (C NMR), and high-resolution mass spectrometry (HRMS). Moreover, a nearly coplanar single crystal structure is successfully obtained and form a mesh structure through intermolecular multiple C─H···F hydrogen bond interactions.

Central memory CD4+ T cells play a protective role against immune checkpoint inhibitor-associated myocarditis.

Aims: The widespread use of immune checkpoint inhibitors (ICIs) has demonstrated significant survival benefits for cancer patients and also carries the risk of immune-related adverse events. ICI-associated myocarditis is a rare and serious adverse event with a high mortality rate. Here, we explored the mechanism underlying ICI-associated myocarditis.

One-photon three-dimensional printed fused silica glass with sub-micron features.

The applications of silica-based glass have evolved alongside human civilization for thousands of years. High-precision manufacturing of three-dimensional (3D) fused silica glass objects is required in various industries, ranging from everyday life to cutting-edge fields. Advanced 3D printing technologies have emerged as a potent tool for fabricating arbitrary glass objects with ultimate freedom and precision.

GTPase activity of porcine Mx1 plays a dominant role in inhibiting the N-Nsp9 interaction and thus inhibiting PRRSV replication.

Unlabelled: Porcine Mx1 is a type of interferon-induced GTPase that inhibits the replication of certain RNA viruses. However, the antiviral effects and the underlying mechanism of porcine Mx1 for porcine reproductive and respiratory syndrome virus (PRRSV) remain unknown. In this study, we demonstrated that porcine Mx1 could significantly inhibit PRRSV replication in MARC-145 cells.

Effect of Eccentricity Difference on the Mechanical Response of Microfluidics-Derived Hollow Silica Microspheres during Nanoindentation.

Hollow microspheres as the filler material of syntactic foams have been adopted in extensive practical applications, where the physical parameters and their homogeneity have been proven to be critical factors during the design process, especially for high-specification scenarios. Based on double-emulsion droplet templates, hollow microspheres derived from microfluidics-enabled soft manufacturing have been validated to possess well-controlled morphology and composition with a much narrower size distribution and fewer defects compared to traditional production methods. However, for more stringent requirements, the innate density difference between the core-shell solution of the double-emulsion droplet template shall result in the wall thickness heterogeneity of the hollow microsphere, which will lead to unfavorable mechanical performance deviations.

Oral phages prophylaxis against mixed Escherichia coli O157:H7 and Salmonella Typhimurium infections in weaned piglets.

Escherichia coli and Salmonella Typhimurium are the main pathogens of diarrhea in weaned piglets. The prevention of bacterial diarrhea in weaned piglets by phage is rarely reported. We conducted this study to evaluate the preventive effect of phages on mixed Escherichia coli and Salmonella Typhimurium infections in weaned piglets.

Research trends of acupuncture therapy on facial paralysis in a decade spanning 2013-2023: A bibliometric analysis.

Objective: This study aimed to employ bibliometric approaches to assess the worldwide scientific achievements in acupuncture for facial paralysis research from 2013 to 2023, and explore the hotspots and frontiers.

Methods: Articles related to acupuncture facial paralysis were retrieved from the Web of Science Core Collection (WoSCC). CiteSpace was utilized to examine journals, publication year, country, institution, cited authors, as well as authors.

A Meta-Analysis on the Efficacy of Acupuncture as an Adjuvant Therapy for Schizophrenia.

Objective: To systematically evaluate the efficacy of acupuncture in the treatment of schizophrenia.

Methods: We searched China National Knowledge Infrastructure (CNKI), Wanfang Database, Chongqing VIP Chinese Science and Technology Periodical Database (VIP), China Biology Medicine Database (CBM), PubMed, Embase, Web of Science, Cochrane Library for relevant literature on the acupuncture treatment of schizophrenia published from database inception to May 17, 2023. The evaluation criteria included total effective rate, incidence of adverse reactions, TESS scale, PANSS scale, BPRS scale, SANA scale, SAPS scale.

Oral phage therapy with microencapsulated phage A221 against Escherichia coli infections in weaned piglets.

Background: Escherichia coli (E. coli) is a common pathogen that often causes diarrhea in piglets. Since bacteria are becoming more and more resistant to antibiotics, phages have become a promising alternative therapy.

Layered Polymer Stacking for Stable Interfaces and Dendrite Growth Inhibition in All-Solid-State Lithium Batteries.

To improve the ionic conductivity and cycling stability of solid-state lithium batteries based on poly(ethylene oxide) (PEO) electrolytes, we developed a sandwich-structured composite polymer electrolyte (sandwich-CPE) PEO-TiN/PEO-LiYF/PEO-TiN. The sandwich-CPE delivers a high ionic conductivity of 1.7 × 10 S cm at 30 °C and a wide potential window of 0 to 5.

Biological characteristics and genomic analysis of a novel Escherichia phage Kayfunavirus CY1.

As the problem of bacterial resistance becomes serious day by day, bacteriophage as a potential antibiotic substitute attracts more and more researchers' interest. In this study, Escherichia phage Kayfunavirus CY1 was isolated from sewage samples of swine farms and identified by biological characteristics and genomic analysis. One-step growth curve showed that the latent period of phage CY1 was about 10 min, the outbreak period was about 40 min and the burst size was 35 PFU/cell.

Diestervinyl-functionalized acceptor-acceptor type dithienylethenes with efficient photochromic performance.

Exploring novel dithienylethenes (DTEs) with efficient photochromism has drawn increasing attention in virtue of the potential applications for photoelectric functional materials. In this contribution, we presented two novel acceptor-acceptor (A-A) type DTE derivatives (4a and 4b) by incorporating the diestervinyl moieties with strong electron-withdrawing capacity into two sides of DTE skeleton. The corresponding structures were well confirmed by the NMR (H and C) and HRMS.

Mechanical Properties of Internally Hierarchical Multiphase Lattices Inspired by Precipitation Strengthening Mechanisms.

In metal metallurgy, precipitation strengthening is widely used to increase material strength by utilizing the impediment effect of the second-phase particles on dislocation movements. Inspired by this mechanism, in this paper, novel multiphase heterogeneous lattice materials are developed with enhanced mechanical properties utilizing a similar hindering effect of second-phase lattice cells on the shear band propagation. For this purpose, biphase and triphase lattice samples are fabricated using high-speed multi jet fusion (MJF) and digital light processing (DLP) additive manufacturing techniques, and a parametric study is carried out to investigate their mechanical properties.

Acupuncture treatment of a pregnant patient with Bell's palsy in the third trimester: Case report.

At present, the optimal treatment for Bell's palsy remains controversial, and the combination of corticosteroids and antiviral medication is usually recommended in the early stage. However, treatment is often delayed because the effects of these drugs on pregnant women and fetuses are still unclear. As a safe and effective complementary alternative therapy, acupuncture can alleviate Bell's palsy symptoms and improve the quality of life of the patient.

Broad-Spectrum Phages PSE-D1 and PST-H1 Controls in Foods.

Food contamination by can lead to serious foodborne diseases that constantly threaten public health. Innovative and effective strategies are needed to control foodborne pathogenic contamination since the incidence of foodborne diseases has increased gradually. In the present study, two broad-spectrum phages named phage PSE-D1 and phage PST-H1 were isolated from sewage in China.

Development of a phage-based electrochemical biosensor for detection of Escherichia coli O157: H7 GXEC-N07.

Escherichia coli (E. coli) O157:H7 is one of the most important foodborne pathogens that causing severe foodborne diseases. With the development of foodborne diseases, there is an urgent need to seek new methods for early detection and monitoring of E.

A data plane security model of SR-BE/TE based on zero-trust architecture.

Facing the untrusted threats of network elements and PKI/CA faced by SR-BE/TE (Segment Routing-BE/TE) data plane in the zero-trust network environment, firstly, this paper refines it into eight specific security issues. Secondly, an SR-BE/TE data plane security model ZbSR (ZTA-based SR) based on zero-trust architecture is proposed, which reconstructs the original SR control plane into a "trust-agent" two-layer plane based on 4 components of the controller, agent, cryptographic center and information base. On one hand, we distinguish between the two segment list generation modes and proposes corresponding data exchange security algorithms, by introducing north-south security verification based on identity authentication, trust evaluation, and key agreement before the terminal device establishes an east-west access connection, so reliable data exchange between terminal devices can be realized.

Green-/NIR-light-controlled rapid photochromism featuring reversible thermally activated delayed fluorescence and photoelectronic switching.

Fluorescent dithienylethene-based photochromic materials have been attracting considerable attention owing to their wide applications in biological and materials sciences. However, the limitations of detrimental UV irradiation for photocyclization, short emission lifetime, and inefficient photoresponsive speed still need to be addressed. Herein, a novel dithienylethene photochromic molecule, BFBDTE, has been prepared by the incorporation of a difluoroboron β-diketonate (BFbdk) unit.

Dithienylethene-Bridged Fluoroquinolone Derivatives for Imaging-Guided Reversible Control of Antibacterial Activity.

The emerging field of photopharmacology has offered a promising alternative to guard against the bacterial resistance by effectively avoiding antibiotic accumulation in the body or environment. However, the degradation, toxicity, and thermal reversibility have always been an ongoing concern for potential applications of azobenzene-based photopharmacology. Developing novel photopharmacological agents based on a more matched switch is highly in demand and remains a major challenge.