Gradient Luminescence Enhancement in Organic Metal Halide Perovskites via the Suppression of [SbCl] Unit Distortion.

Intrinsic stereochemical activity of the 5s electron configuration in Sb leads to structural distortion within [SbCl] units, which, while stabilizing the material, paradoxically diminishes luminescence intensity due to induced asymmetry. To address this issue, a strategy, which encompasses increasing the structural dimensions and introducing In doping, was developed to mitigate the geometrical distortion in the [SbCl] units within the metal-organic perovskite (DABCO)SbCl·HO and (DABCO)SbCdCl·2HO (DABCO = triethylenediamine). This dimensional augmentation confines lattice distortion effectively, and the In doping modifies the 5s electron configuration of Sb, thereby reducing the distortion at its origin.

Correction: Highly efficient yellow emission and abnormal thermal quenching in Mn-doped RbCdCl.

Correction for 'Highly efficient yellow emission and abnormal thermal quenching in Mn-doped RbCdCl' by Dayu Huang , , 2023, , 5715-5723, https://doi.org/10.1039/D3DT00453H.

Surface Oxygen Vacancies and Corona Polarization of BiTiO Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy.

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited piezoelectric catalytic efficiency is a serious bottleneck for its practical application. Excellent piezoelectric catalysts with high piezoelectric coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently.

Fabrication of Interface Engineered S-Scheme Heterojunction Nanocatalyst for Ultrasound-Triggered Sustainable Cancer Therapy.

In order to establish a set of perfect heterojunction designs and characterization schemes, step-scheme (S-scheme) BiOBr@BiS nanoheterojunctions that enable the charge separation and expand the scope of catalytic reactions, aiming to promote the development and improvement of heterojunction engineering is developed. In this kind of heterojunction system, the Fermi levels mediate the formation of the internal electric field at the interface and guide the recombination of the weak redox carriers, while the strong redox carriers are retained. Thus, these high-energy electrons and holes are able to catalyze a variety of substrates in the tumor microenvironment, such as the reduction of oxygen and carbon dioxide to superoxide radicals and carbon monoxide (CO), and the oxidation of HO to hydroxyl radicals, thus achieving sonodynamic therapy and CO combined therapy.

Defect-Repaired g-CN Nanosheets: Elevating the Efficacy of Sonodynamic Cancer Therapy Through Enhanced Charge Carrier Migration.

Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains the primary limiting factor for the clinical application of this treatment method. Here, defect-repaired graphene phase carbon nitride (g-CN) nanosheets are prepared and utilized for enhanced SDT in anti-tumor treatment.

Multimode Luminescence Tailoring and Improvement of Cs NaHoCl Cryolite Crystals via Sb /Yb Alloying for Versatile Photoelectric Applications.

Lead-free halide double perovskites are currently gaining significant attention owing to their exceptional environmental friendliness, structural adjustability as well as self-trapped exciton emission. However, stable and efficient double perovskite with multimode luminescence and tunable spectra are still urgently needed for multifunctional photoelectric application. Herein, holmium based cryolite materials (Cs NaHoCl ) with anti-thermal quenching and multimode photoluminescence were successfully synthesized.

Metal Halide Single Crystals RbCdCl:Sn and RbSnCl with Blue and White Emission Obtained via a Hydrothermal Process.

Until now, effective blue light-emitting materials are essentially needed for the creation of white light and precise color renderings in real-world applications, but the efficiency of blue light-emitting materials has lagged far behind. Here, we present a hydrothermal method to synthesize tin-based metal halide single crystals (RbCdCl:Sn and RbSnCl). Two single crystal materials with different shapes and phases can simultaneously be synthesized in the same stoichiometric ratio.

Defect Engineering in Biomedical Sciences.

With the promotion of nanochemistry research, large numbers of nanomaterials have been applied in vivo to produce desirable cytotoxic substances in response to endogenous or exogenous stimuli for achieving disease-specific therapy. However, the performance of nanomaterials is a critical issue that is difficult to improve and optimize under biological conditions. Defect-engineered nanoparticles have become the most researched hot materials in biomedical applications recently due to their excellent physicochemical properties, such as optical properties and redox reaction capabilities.

Assembling AgAuSe Quantum Dots with Peptidoglycan and Neutrophils to Realize Enhanced Tumor Targeting, NIR (II) Imaging, and Sonodynamic Therapy.

Significant progress is made in drug delivery systems, but they still face problems such as poor stability in vivo, off-target drugs, and difficulty in crossing biological barriers. It is urgent to realize efficient targeted delivery and precisely controlled sustained release of drugs by using the integrated nanoplatform. Theranostic nanoplatform is a new biomedical technology that combines diagnosis or monitoring of diseases with treatment.

Highly efficient yellow emission and abnormal thermal quenching in Mn-doped RbCdCl.

In this paper, Mn-doped RbCdCl metal halide single crystals were prepared by a hydrothermal method. The RbCdCl:Mn metal halide exhibits yellow emission with photoluminescence quantum yields (PLQY) as high as 88%. Due to the thermally induced electron detrapping, RbCdCl:Mn also displays good anti-thermal quenching (ATQ) behavior with thermal quenching resistance (131% at 220 °C).

Titanium-Based Nanoarchitectures for Sonodynamic Therapy-Involved Multimodal Treatments.

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs a combination of low-intensity ultrasound and chemical entities, known as a sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer and antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced as a sonosensitizers, including, titanium-based nanomaterials, thanks to their high biocompatibility, catalytic efficiency, and customizable physicochemical features.

Rational Design of Platinum-Bismuth Sulfide Schottky Heterostructure for Sonocatalysis-Mediated Hydrogen Therapy.

Conventional sonodynamic therapy is unavoidably limited by the tumor microenvironment, although many sonosensitizers have been developed to improve them to a certain extent. Given this, a concept of sonocatalytic hydrogen evolution is proposed, which is defined as an oxygen-independent therapeutics. To demonstrate the feasibility of the concept, the narrow-bandgap semiconductor bismuth sulfide (Bi S ) is selected as the sonocatalyst and platinum (Pt) nanoparticles are grown in situ to optimize their catalytic performance.

L-buthionine sulfoximine encapsulated hollow calcium peroxide as a chloroperoxidase nanocarrier for enhanced enzyme dynamic therapy.

The appropriate design of multifunctional nanocarriers for chloroperoxidase (CPO) delivery and the simultaneous improvement of the efficiency of enzyme dynamic therapy (EDT) remain significant challenges. Herein, we report a facile one-step route to obtain a multifunctional nanocarrier for the formation of sodium hyaluronate-modified hollow calcium peroxide spheres with encapsulated L-buthionine sulfoximine (BSO), followed by delivery of CPO for enhanced EDT. After effective accumulation at the tumor sites, the nanocomposite rapidly decomposes and releases Ca, BSO molecules, CPO, and concurrently generates a large volume of hydrogen peroxide (HO) in the endogenous tumor microenvironment (TME).

Tumor Microenvironment-Responsive Cu/CaCO -Based Nanoregulator for Mitochondrial Homeostasis Disruption-Enhanced Chemodynamic/Sonodynamic Therapy.

The efficiency of reactive oxygen species (ROS)-mediated cancer therapy is restrained by intrinsic characteristics in the tumor microenvironment (TME), such as overexpressed glutathione (GSH), hypoxia and limited efficiency of H O . In this work, intelligent copper-dropped calcium carbonate loading sonosensitizer Ce6 nanoparticles (Cu/CaCO @Ce6, CCC NPs) are established to realize TME-responsive self-supply of oxygen and successively Ca -overloading-strengthened chemodynamic therapy/sonodynamic therapy (CDT/SDT). CCC NPs release Ca , Cu , and Ce6 in weakly acid and GSH-excessive TME.

Mn /Fe /Co and Tetrasulfide Bond Co-Incorporated Dendritic Mesoporous Organosilica as Multifunctional Nanocarriers: One-Step Synthesis and Applications for Cancer Therapy.

Enriching the application of multifunctional dendritic mesoporous organosilica (DMOS) is still challenging in anti-cancer research. Herein, manganese ions, iron ions, or cobalt ions and tetrasulfide bonds are co-incorporated into the framework of DMOS to yield multifunctional nanoparticles denoted as Mn-DMOS, Fe-DMOS, or Co-DMOS by directly doping metal ions during the synthetic process. Due to co-incorporation of metal ions and tetrasulfide bonds, these designed nanocarriers have more functions rather than only for cargo delivery.

High-sensitivity fluorescence detection for lung cancer CYFRA21-1 DNA based on accumulative hybridization of quantum dots.

Sensitive detection of circulating tumor DNA (ctDNA) has attracted growing attention owing to its potential application in diagnostics of cancer. In this study, we synthesized hydrophilic AgInS@ZnS core-shell quantum dot nanocrystals and magnetic FeO nanoparticles, and then the ctDNA triggered hybridization chain reaction was used to detect the CYFRA21-1 DNA associated with lung cancer. In the presence of CYFRA21-1 DNA, three hairpin structures were activated to turn on successively, resulting in the accumulation of quantum dots and eliciting considerable changes of the fluorescence signal.

A tumor microenvironment-responsive Co/ZIF-8/ICG/Pt nanoplatform for chemodynamic and enhanced photodynamic antitumor therapy.

Hypoxia and the overexpression of hydrogen peroxide (HO) in the tumor microenvironment (TME) are conducive to cancer cell proliferation, which greatly hinders cancer treatment. Here, we design a novel TME-responsive therapeutic nanoplatform Co/ZIF-8/ICG/Pt (CZIP) to achieve chemodynamic therapy (CDT) and enhanced photodynamic therapy (PDT). In this nanoplatform, under near-infrared light (NIR) irradiation, the photosensitizer indocyanine green (ICG) can generate singlet oxygen (O) for cancer cell apoptosis.

One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy.

Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen peroxide (HO) self-supplying agent for enhanced tumor therapy. However, a single kind of metal peroxide is insufficient to achieve more effective antitumor performance. Here, a hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by a simple one-step strategy.

Core-Shell Structured Upconversion/Lead-Free Perovskite Nanoparticles for Anticounterfeiting Applications.

In view of their excellent luminescence properties, nanocrystalline metal halide perovskites have diverse optoelectronic applications, including those related to anticounterfeiting. However, high-quality optical anticounterfeiting typically requires multiple encryptions relying on several optical modes to ensure information security. Herein, an efficient anticounterfeiting strategy based on dual optical encryption is realized by combining up- and downconversion luminescence in a nanocomposite with NaYF  : Er ,Yb as core and a CsMnCl as shell.

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy.

Pyroptosis, which is a mode of programmed cell death, has proven effective for cancer therapy. However, efficient pyroptosis inducers for tumor treatment are limited. This study proposes biodegradable KZrF:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy.

Multifunctional carbon monoxide nanogenerator as immunogenic cell death drugs with enhanced antitumor immunity and antimetastatic effect.

The limited effect of immune checkpoint blockade (ICB) immunotherapy is subjected to the immuno-suppressive tumor microenvironment (TME). It is still a challenge to reverse the immune-suppressive state in clinical cancer therapy. Immunogenic cell death (ICD) is a way for inducing the therapeutical tumor immune system.