Publications by authors named "Ziying Ye"

Significance: The current neuromodulation treatment for post-stroke cognitive impairment (PSCI) is formulated based on interhemispheric inhibition, which is particularly relevant in the context of motor disorders after stroke. However, the pathological mechanism of PSCI remains unclear, which is completely different from motor disorders. Therefore, exploring the pathological brain characteristics of PSCI can provide a reliable theoretical basis for effective neuromodulation treatment for it.

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Background And Objective: Childhood is a crucial period for the formation of an individual's attachment type. Previous studies focused more on how to directly intervene in children's mental health problems such as depression, and less on how to improve children's mental health from the perspective of attachment relationship. Secure base, as one of the core concepts of attachment theory, plays an important role in the whole process of children's psychological development.

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Article Synopsis
  • The study aims to provide a detailed overview of the existing knowledge and key areas of research regarding obstacles and strategies for implementing clinical practice guidelines.
  • A comprehensive analysis of 21,768 publications from various journals revealed that the U.S., U.K., and Canada lead in contributions, with significant findings on collaboration networks among institutions.
  • Key research topics identified include public health, evidence-based medicine, and barriers to guideline implementation, highlighting future investigation areas like societal impacts and inequalities.
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'Antibiotics under our feet' is a Scottish citizen science project that aimed to raise science capital in primary school learners and their teachers through measurement of microbial diversity in urban soil samples in the search for novel antimicrobial compounds. Resistance to antibiotics is rising, posing a global threat to human health. Furthermore, science, technology, engineering and mathematics (STEM) skills are in crisis, jeopardising our capacity to mobilise as a society to fight antimicrobial resistance (AMR).

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Importance: Large language models (LLMs) may facilitate the labor-intensive process of systematic reviews. However, the exact methods and reliability remain uncertain.

Objective: To explore the feasibility and reliability of using LLMs to assess risk of bias (ROB) in randomized clinical trials (RCTs).

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Objectives: Differentiating intestinal tuberculosis (ITB) from Crohn's disease (CD) remains a diagnostic dilemma. Misdiagnosis carries potential grave implications. We aim to establish a multidisciplinary-based model using machine learning approach for distinguishing ITB from CD.

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The human vaginal epithelium is a crucial component of numerous reproductive processes and serves as a vital protective barrier against pathogenic invasion. Despite its significance, a comprehensive exploration of its molecular profiles, including molecular expression and distribution across its multiple layers, has not been performed. In this study, we perform a spatial transcriptomic analysis within the vaginal wall of human fetuses to fill this knowledge gap.

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Phycocyanobilin (PCB) is a blue pigment with antioxidant, anti-inflammatory, and anticancer properties. It is used in the medical and cosmetic industries. In this study, a high-expression plasmid, pET-30a-PCB, was constructed for expression of PCB in Escherichia coli BL21(DE3).

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In women, a healthy and functional vagina is important for the maintenance of a good quality of life. Various factors, including congenital anomalies, cancer, trauma, infections, inflammation, or iatrogenic injuries, can lead to damage or loss of the vaginal structure, necessitating repair or replacement. Often, such reconstruction procedures involve the use of nonvaginal tissue substitutes, like segments of the large intestine or skin, which are less than ideal both anatomically and functionally.

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Article Synopsis
  • Traditional Chinese Medicine (TCM) has significant empirical traditional medicines but requires more research to confirm the efficacy and safety of its remedies.
  • * The study aims to evaluate the quality of insomnia clinical practice guidelines that include TCM recommendations, assessing the strength and consistency of evidence behind these recommendations.
  • * Thirteen insomnia guidelines were analyzed, revealing overall low quality, with many evidence-based recommendations lacking strong support; only a small percentage received high certainty in their backing.
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Article Synopsis
  • Maternal serum levels of soluble programmed cell death-1 (sPD-1) and its ligand (sPD-L1) were investigated as potential biomarkers for missed miscarriage (MM), with findings suggesting decreased sPD-L1 levels in MM patients.
  • The study involved three cohorts, including a discovery cohort of 108 MM patients and healthy pregnant women, a validation cohort of MM patients and women with induced abortions, and a prospective observational study of IVF patients, all assessing serum levels of sPD-1 and sPD-L1.
  • Results showed that sPD-L1 levels in MM patients were significantly lower (about 50% reduction) compared to healthy pregnant controls, indicating its potential role as a predictive biomarker for missed
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Ferroptosis, a newly identified iron-dependent form of cell death, has recently been implicated in the pathogenesis of Parkinson's disease (PD). Dl-3-n-butylphthalide (NBP) attenuates behavioral and cognitive deficits in animal models of PD. However, the potential of NBP to prevent dopaminergic neuron death by suppressing ferroptosis has rarely been explored.

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Intrauterine adhesions (IUA), characterized by endometrial fibrosis, is a challenging clinical issue in reproductive medicine. We previously demonstrated that epithelial-mesenchymal transition (EMT) and fibrosis of endometrial stromal cells (HESCs) played a vital role in the development of IUA, but the precise pathogenesis remains elucidated. Ferroptosis has now been recognized as a unique form of oxidative cell death, but whether it is involved in endometrial fibrosis remains unknown.

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Oligosaccharides derived from agar, that is, agarooligosaccharides and neoagarooligosaccharides, have demonstrated various kinds of bioactivities which have been utilized in a variety of fields. Enzymatic hydrolysis is a feasible approach that principally allows for obtaining specific agar oligosaccharides in a sustainable way at an industrial scale. This review summarizes recent technologies employed to improve the properties of agarase.

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